The caBmpr1a transgene has a floxed Tau-β-galactosidase gene followed by a constitutively active mutant form of human BMP receptor type IA (caBmpr1a Q227D), an IRES sequence, and the EGFP coding sequence. Transgenic mice have widespread expression of lacZ prior to exposure to Cre recombinase. When bred with mice that express Cre recombinase, offspring will have the floxed-lacZ gene deleted and subsequent expression of caBmpr1a and EGFP in the cre-expressing cells. These mice may be useful for studying BMP signaling in tissues where Cre expresses such as cartilage and muscle, osteoclastogenesis (via RANKL-OPG pathway and/or canonical Wnt signaling), age dependant bone loss, osteoporosis, chondrodysplasia, fibrodysplasia ossificans progressive, and mineralization in muscle/skeletal development.
Manas Ray, NIEHS
| Genetic Background | Generation |
|---|---|
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| Allele Type |
|---|
| Transgenic (Conditional ready (e.g. floxed), Reporter, Constitutively active, Inserted expressed sequence, Humanized sequence) |
