Heterozygous mice exhibit skeletal abnormalities. Homozygous mice die early in embryonic development.
Read More +Genetic Background | Generation |
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Allele Type | Gene Symbol | Gene Name |
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Spontaneous | Rpl38 | ribosomal protein L38 |
Homozygosity for the tail short mutation causes early embryonic lethality. Heterozygotes are smaller than normal and have variably shortened tails with flexures. Skeletal abnormalities are found with varying expressivity including vertebral fusions, bilateral asymmetry of the length of the humerus and tibia, triphalangy of digit 1 of the forefoot, an extra pair of ribs, and craniofacial defects. Embryonic anemia and reduced fertility are also found.
The Ts mutation arose spontaneously in 1946 at the National Cancer Institute in BALB/c (strain C of the Bagg albino strain) when that inbred was at generation F63. W.C. Morgan gave this mutant subline to George Snell at The Jackson Laboratory in 1950 and Snell outcrossed it to C57BL/6, C57BR/a, and BALB/cSn before inbreeding began on this new background and the line was transferred to Skippy Lane. The TSJ/Le inbred reached generation F41 in 1979 and F130 in 2007. When this inbred reached generation F132 it was backcrossed repeatedly to BALB/cJ and in 2010 sperm was cryopreserved from males heterozygous for Ts and Tyrc and homozygous for Tyrp1b then at generation N4. Cryorecovery using BALB/cJ females for in vitro fertilization has proven successful.
Allele Name | tail-short |
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Allele Type | Spontaneous |
Allele Synonym(s) | T-s |
Gene Symbol and Name | Rpl38, ribosomal protein L38 |
Gene Synonym(s) | |
Strain of Origin | BALB/c |
Chromosome | 11 |
Molecular Note | An 18,189 kb region (from position 114,517 - 114,536 kb) was deleted and replaced with a 657 bp insertion showing high sequence similarity to the gag/pro-pol-dUTPase genes of the endogenous retrovirus MuERV-L. This deletion encompasses all of the exons of Rpl38. |
When using the tail-short mouse strain in a publication, please cite the originating article(s) and include JAX stock #011114 in your Materials and Methods section.
Facility Barrier Level Descriptions
Service/Product | Description | Price |
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Heterozygous or Wild-type for Ts |
Frozen Mouse Embryo | C(TSJ)-Rpl38<Ts>/GrsrJ | $2595.00 |
Frozen Mouse Embryo | C(TSJ)-Rpl38<Ts>/GrsrJ | $2595.00 |
Frozen Mouse Embryo | C(TSJ)-Rpl38<Ts>/GrsrJ | $3373.50 |
Frozen Mouse Embryo | C(TSJ)-Rpl38<Ts>/GrsrJ | $3373.50 |
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The Jackson Laboratory has rigorous genetic quality control and mutant gene genotyping programs to ensure the genetic background of JAX® Mice strains as well as the genotypes of strains with identified molecular mutations. JAX® Mice strains are only made available to researchers after meeting our standards. However, the phenotype of each strain may not be fully characterized and/or captured in the strain data sheets. Therefore, we cannot guarantee a strain's phenotype will meet all expectations. To ensure that JAX® Mice will meet the needs of individual research projects or when requesting a strain that is new to your research, we suggest ordering and performing tests on a small number of mice to determine suitability for your particular project. We do not guarantee breeding performance and therefore suggest that investigators order more than one breeding pair to avoid delays in their research.
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