Mice homozygous for the twisted 3 Jackson mutation have a severe head-tilt and move in the circling pattern indicative of a vestibular defect. In a swim test they swim tilted to one side usually just below the surface of the water. ABR readings show that these mice are severely hearing impaired at wean age and profoundly deaf by 70 days of age. Otoconial deficiencies exist that are likely due to displacement of the otolithic membrane.
The twisted 3 Jackson mutation arose spontaneously on a congenic strain, D2.B6-(D2Mit61-D1Mit66)/Ei, in the laboratory of Dr. Eva Eicher at The Jackson Laboratory in 2006. This mutation was found to have occurred in DBA/2J derived sequence and was backcrossed onto the C57BL/6J inbred background for 7 generations before being maintained by sibling intercrossing heterozygous females with homozygous males.
|Allele Name||twister 3 Jackson|
|Gene Symbol and Name||Otog, otogelin|
|Strain of Origin||D2.B6-(D2Mit61-D2Mit66)/Ei|
|Molecular Note||This mutation was proven allelic with the original twister mutation by a noncomplementation test.|