Mice that are heterozygous for the targeted mutation are viable, fertile, normal in size and do not display any gross physical or behavioral abnormalities.  Homozygotes are viable but sterile.  No gene product (mRNA or protein) is detected by RT-PCR analysis of testes from homozygotes.  Male homozygotes display decreased testis weight and incomplete spermatogenesis (arrest at the pachytene stage).  Female homozygotes exhibit reduced germ cell number in neonatal ovaries and no forming follicles.  Homozygotes have abnormal homologous chromosome pairing, impaired double strand break repair and defective sex body (XY body) formation.  This mutant mouse strain may be useful in studies of meiotic arrest, infertility, and double-stranded break repair.

Mice homozygous for this knockout allele exhibit germ cell defects resulting in sterility. 


Typically mice are recovered in 12-16 weeks. Contact Customer Service to place an order or for more information.

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