Mice homozygous for the targeted mutation die before or shortly after birth due to
developmental defects. Homozygotes on the A/J background exhibit exencephaly (severe
neural tube closure defects), with a higher embryonic lethality than homozygotes on the
C57BL/6 or 129 backgrounds. None exhibit facial clefting. The Donating Investigator reports that homozygotes display flattened or shorter snouts, iris malformation and polydactyly.  The penetrance of the phenotype
is highly background dependent. Heterozygotes are viable and fertile with timely cranial
neural tube closure, and a low incidence of facial clefting.  The Donating Investigator reports some heterozygotes on the A/J background exhibit lateral facial clefting. This mutant strain may be useful
in studies of facial cleft formation, 1p36 deletion syndrome, oncogene function, apoptosis,
and neural tube and skeletal muscle defects.


Mice homozygous for this targeted mutation of Sloan-Kettering viral oncogene homolog (<i>Ski</i>) die before or shortly after birth due to developmental defects.  Homozygotes on the A/J background exhibit exencephaly (severe neural tube closure defects), with a higher embryonic lethality than homozygotes on the C57BL/6 or 129 backgrounds.  None exhibit facial clefting.  None exhibit facial clefting.  This mutant strain may be useful in studies of facial cleft formation, 1p36 deletion syndrome, oncogene function, apoptosis, and neural tube and skeletal muscle defects.

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