B6.129P2-Slc25a37^Gt(XB454)Byg/LlpJ

Stock number: 008564
Research areas: Hematological Research

Description

Homozygotes for this null allele develop profound embryonic hypochromic anemia and all die by E11.5.

Detailed description

This solute carrier family protein localizes to the inner mitochondrial membrane where it is essential for appropriate iron importation. Homozygotes for this null allele fail to incorporate iron into heme, develop profound embryonic hypochromic anemia and all die by E11.5. Porphyria is not found in these mice. This strain has been used to assess the role of other proteins in the heme regulatory pathway.

Development

This gene trap mutation was made in the laboratory of Luanne Peters using E14 ES cell clone XB454 from Bay Genomics. This mutation was backcrossed onto the C57BL/6J background and sperm was frozen from heterozygous males at generation N10.

Allele

Symbol: Slc25a37^Gt(XB454)Byg
Name: gene trap XB454, BayGenomics
MGI accession ID: MGI:3797259
Generation method: Gene trapped
Marker symbol: Slc25a37
Marker name: solute carrier family 25, member 37
Marker synonyms: 1700020E22Rik; 4930513O14Rik; 4930526G11Rik; C330015G08Rik; Frascati; HT015; Mfrn; MFRN1; mitoferrin; MSC; Mscp; PRO1278; PRO1584; PRO2217; RGD1359361
Chromosome: 14
Strain of origin: 129P2/OlaHsd