Homozygotes for this null allele develop profound embryonic hypochromic anemia and all die by E11.5.
Read More +Genetic Background | Generation |
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000664 C57BL/6J |
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Allele Type | Gene Symbol | Gene Name |
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Gene trapped | Slc25a37 | solute carrier family 25, member 37 |
This solute carrier family protein localizes to the inner mitochondrial membrane where it is essential for appropriate iron importation. Homozygotes for this null allele fail to incorporate iron into heme, develop profound embryonic hypochromic anemia and all die by E11.5. Porphyria is not found in these mice. This strain has been used to assess the role of other proteins in the heme regulatory pathway.
This gene trap mutation was made in the laboratory of Luanne Peters using E14 ES cell clone XB454 from Bay Genomics. This mutation was backcrossed onto the C57BL/6J background and sperm was frozen from heterozygous males at generation N10.
Allele Name | gene trap XB454, BayGenomics |
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Allele Type | Gene trapped |
Allele Synonym(s) | |
Gene Symbol and Name | Slc25a37, solute carrier family 25, member 37 |
Gene Synonym(s) | |
Strain of Origin | 129P2/OlaHsd |
Chromosome | 14 |
When using the B6.129P2-Slc25a37Gt(XB454)Byg/LlpJ mouse strain in a publication, please cite the originating article(s) and include JAX stock #008564 in your Materials and Methods section.
Facility Barrier Level Descriptions
Service/Product | Description | Price |
---|---|---|
Heterozygous or wildtype for Slc25a37<Gt(XB454)Byg> |
Frozen Mouse Embryo | B6.129P2-Slc25a37<Gt(XB454)Byg>/LlpJ | $2595.00 |
Frozen Mouse Embryo | B6.129P2-Slc25a37<Gt(XB454)Byg>/LlpJ | $2595.00 |
Frozen Mouse Embryo | B6.129P2-Slc25a37<Gt(XB454)Byg>/LlpJ | $3373.50 |
Frozen Mouse Embryo | B6.129P2-Slc25a37<Gt(XB454)Byg>/LlpJ | $3373.50 |
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