This NOD congenic strain may be useful to identify candidate genes on Chromosome 1 associated with diabetes resistance and to identify genes with common roots in multiple autoimmune diseases.
Marcia McDuffie, Univ. of Virginia Dept. of Medicine
This NOD consomic strain, commonly referred to as NOD.Zc1, carries Chromosome 1 alleles, D1Mit316 (10Mb) through D1Mit293 (194Mb) derived from NZM2328 that includes the Idd5 region. NOD.Zc1 is viable, fertile, normal in size, and do not display any gross physical or behavioral abnormalities. Diabetes incidence in this diabetes/lupus resistant strain is reported to be 10% in the females and 0% in males compared to 70% in female and 40% in male NOD/Bdc control mice. This strain will be useful to identify candidate genes associated with diabetes resistance and to identify genes with common roots in multiple autoimmune diseases.
This NOD consomic stock contains Chromosome 1 derived from NZM2328, a lupus nephritis susceptible strain. Donating investigator reports (NZM2328 X NOD) F2 females homozygous for NOD derived H2g7, MHC class I K and MHC class II- I AB alleles were selected for backcrossing to NOD/Bdc. This diabetes resistant line was analyzed using microsatellite markers. Microsatellite marker analysis identified D1Mit316 (10Mb) through D1Mit293 (194Mb) to be of NZM2328 origin. In 2008, the Type 1 Diabetes Resource received this stock at N5F19.
Currently there are no related genes or alleles for this strain.