Stock No.'s 008053, 008054, 008055, 008056, 008057, 008058, 008059 and 008060, are the result of crossing segments of C57L/J derived Chromosome 11 into the NOD/Bdc background. These strains experience significantly reduced diabetes and are useful for identifying candidate genes within the Idd4 subloci.
Marcia McDuffie, Univ. of Virginia Dept. of Medicine
Genetic Background | Generation |
---|---|
001976 NOD/ShiLtJ |
|
Marker Symbol | Marker Name | |
---|---|---|
Csf2 | colony stimulating factor 2 (granulocyte-macrophage) | |
Idd4 | insulin dependent diabetes susceptibility 4 | |
D11Mit339 | DNA Segment, Chr 11, Massachusetts Institute of Technology 339 |
This NOD congenic strain, commonly referred to as NOD.Lc11e or DR3e carries Chromosome 11 alleles, D11Mit164 (56Mb) through D11Mit339 (63Mb) derived from C57L/J including a small part of Idd4 that includes candidate gene Csf2. Diabetes incidence in this strain is reported to be about 53% in females compared to 70% in female NOD control mice. (Davoodi-Semiromi et al 2007).
There appear to be multiple diabetes resistant regions (Idd4) on Chromosome 11, therefore, this strain is useful to identify candidate genes associated with diabetes resistance and to positionally clone the Idd4 resistant loci.
This NOD congenic stock (NOD.Lc11e, DR3e) contains a genomic segment from C57L/J introgressed into Chr 11. Seven additional stocks (Stock No's 008054, 008055, 008056, 008057, 008058, 008059, and 008060) were developed from Stock No. 008053 through backcrossing to NOD once and selective breeding. This model, Stock No. 008056, contains a C57L/J congenic interval D11Mit164 (56Mb) through D11Mit339 (63Mb) containing C57L/J derived Csf2 and NOD/ShiLt derived Stat5a/Stat5b/Stat3 alleles. In 2008, the Type 1 Diabetes Resource received this stock at N6F10.
When using the NOD.Lc11e and DR3e mouse strain in a publication, please cite the originating article(s) and include JAX stock #008056 in your Materials and Methods section.
Facility Barrier Level Descriptions
Service/Product | Description | Price |
---|---|---|
Homozygous, 1 pair minimum |
Frozen Mouse Embryo | NOD.L-(Csf2-D11Mit339)/McdfJ Frozen Embryos | $2595.00 |
Frozen Mouse Embryo | NOD.L-(Csf2-D11Mit339)/McdfJ Frozen Embryos | $2595.00 |
Frozen Mouse Embryo | NOD.L-(Csf2-D11Mit339)/McdfJ Frozen Embryos | $3373.50 |
Frozen Mouse Embryo | NOD.L-(Csf2-D11Mit339)/McdfJ Frozen Embryos | $3373.50 |
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