This NOD congenic strain, commonly referred to as NOD.Lc11e or DR3e carries Chromosome 11 alleles, D11Mit164 (56Mb) through D11Mit339 (63Mb) derived from C57L/J including a small part of Idd4 that includes candidate gene Csf2. Diabetes incidence in this strain is reported to be about 53% in females compared to 70% in female NOD control mice. (Davoodi-Semiromi et al 2007).
There appear to be multiple diabetes resistant regions (Idd4) on Chromosome 11, therefore, this strain is useful to identify candidate genes associated with diabetes resistance and to positionally clone the Idd4 resistant loci.

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Stock No.'s <a href="https://www.jax.org/strain/008053">008053</a>, <a href="https://www.jax.org/strain/008054">008054</a>, <a href="https://www.jax.org/strain/008055">008055</a>, 008056, <a href="https://www.jax.org/strain/008057">008057</a>, <a href="https://www.jax.org/strain/008058">008058</a>, <a href="https://www.jax.org/strain/008059">008059</a> and <a href="https://www.jax.org/strain/008060">008060</a>, are the result of crossing segments of C57L/J derived Chromosome 11 into the NOD/Bdc background. These strains experience significantly reduced diabetes and are useful for identifying candidate genes within the Idd4 subloci.

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NOD.L-(Csf2-D11Mit339)/McdfJ Frozen Embryos