B6.Cg-H2^b4/FlaCmwJ

Stock number: 007959
Strain synonyms: B6.K2
Research areas: Immunology, Inflammation and Autoimmunity Research, Reproductive Biology Research

Description

This strain, commonly known as B6.K2, has a fast Ped or Qa2^positive phenotype was developed as a control for the slow Ped B6.K1 (Stock No. 007958). These mice be used for research in embryonic and post-natal development.

Detailed description

The Qa2 or Ped complex includes four similar genes. The functional (Qa2^positive) and null (Qa2^negative) alleles correlate with the rate of preimplantation embryo development such that Qa2^positive mice are characterized by the fast Ped phenotype and Qa2^negative mice, which do not express the QA2 antigen, are characterized by the slow Ped phenotype. This strain, commonly known as B6.K2, is fast Ped or Qa2^positive. B6.K2 mice were developed to provide a control for B6.K1 mice (Stock No. 007958). (Warner CM, 1993; Watkins A, 2006)

Development

This H2 congenic was developed in the mid-1970s by Dr. Lorraine Flaherty through intercross and backcross of the congenic strains, B6.A-H2-T18^a and B6.AK-H2^k. The H2^b4 haplotype, commonly described as B6.K2, consists of K^b, D^b, Qa2^positive and Tla^b. This strain serves as a control for (Stock No. 007958) B6.Cg-H2^b3/FlaCmwJ (B6.K1) which is Qa2^negative. Both strains have been backcrossed to C57BL/6 for more than 20 generations. Mice from Dr. Flaherty's colony were sent to Dr. Carol Warner at Northeastern University in 1985 and maintained as sibling matings. The colony was donated to the Repository in 2007.

Allele

MGI accession ID: MGI:95894
Marker symbol: H2
Marker name: histocompatibility-2, MHC
Chromosome: 17

Allele

MGI accession ID: MGI:894614
Marker symbol: Ped
Marker name: preimplantation embryo development
Chromosome: 17