This strain, commonly known as B6.K2, has a fast Ped or Qa2positive phenotype was developed as a control for the slow Ped B6.K1 (Stock No. 007958). These mice be used for research in embryonic and post-natal development.
Read More +Genetic Background | Generation |
---|---|
000664 C57BL/6J |
|
Marker Symbol | Marker Name | |
---|---|---|
H2 | histocompatibility-2, MHC | |
Ped | preimplantation embryo development |
This C57BL/6 strain is homozygous for the age related hearing loss mutation Cdh23ahl, which on this background causes progressive hearing loss with onset after 10 months of age.
The Qa2 or Ped complex includes four similar genes. The functional (Qa2positive) and null (Qa2negative) alleles correlate with the rate of preimplantation embryo development such that Qa2positive mice are characterized by the fast Ped phenotype and Qa2negative mice, which do not express the QA2 antigen, are characterized by the slow Ped phenotype. This strain, commonly known as B6.K2, is fast Ped or Qa2positive. B6.K2 mice were developed to provide a control for B6.K1 mice (Stock No. 007958). (Warner CM, 1993; Watkins A, 2006)
This H2 congenic was developed in the mid-1970s by Dr. Lorraine Flaherty through intercross and backcross of the congenic strains, B6.A-H2-T18a and B6.AK-H2k. The H2b4 haplotype, commonly described as B6.K2, consists of Kb, Db, Qa2positive and Tlab. This strain serves as a control for (Stock No. 007958) B6.Cg-H2b3/FlaCmwJ (B6.K1) which is Qa2negative. Both strains have been backcrossed to C57BL/6 for more than 20 generations. Mice from Dr. Flaherty's colony were sent to Dr. Carol Warner at Northeastern University in 1985 and maintained as sibling matings. The colony was donated to the Repository in 2007.
When using the B6.Cg-H2b4/FlaCmwJ mouse strain in a publication, please cite the originating article(s) and include JAX stock #007959 in your Materials and Methods section.
Facility Barrier Level Descriptions
Service/Product | Description | Price |
---|---|---|
Inbred, 1 pair minimum |
Frozen Mouse Embryo | Frozen Embryos | $2595.00 |
Frozen Mouse Embryo | Frozen Embryos | $2595.00 |
Frozen Mouse Embryo | Frozen Embryos | $3373.50 |
Frozen Mouse Embryo | Frozen Embryos | $3373.50 |
Terms are granted by individual review and stated on the customer invoice(s) and account statement. These transactions are payable in U.S. currency within the granted terms. Payment for services, products, shipping containers, and shipping costs that are rendered are expected within the payment terms indicated on the invoice or stated by contract. Invoices and account balances in arrears of stated terms may result in The Jackson Laboratory pursuing collection activities including but not limited to outside agencies and court filings.
The Jackson Laboratory has rigorous genetic quality control and mutant gene genotyping programs to ensure the genetic background of JAX® Mice strains as well as the genotypes of strains with identified molecular mutations. JAX® Mice strains are only made available to researchers after meeting our standards. However, the phenotype of each strain may not be fully characterized and/or captured in the strain data sheets. Therefore, we cannot guarantee a strain's phenotype will meet all expectations. To ensure that JAX® Mice will meet the needs of individual research projects or when requesting a strain that is new to your research, we suggest ordering and performing tests on a small number of mice to determine suitability for your particular project. We do not guarantee breeding performance and therefore suggest that investigators order more than one breeding pair to avoid delays in their research.
What information were you hoping to find through your search?
How easy was it to find what you were looking for?
We may wish to follow up with you. Enter your email if you are happy for us to connect and reachout to you with more questions.
Please Enter a Valid Email Address
Thank you for sharing your feedback! We are working on improving the JAX Mice search. Come back soon for exciting changes.