Homozygotes for this NZB-derived lupus susceptibility QTL (Nba2) develop antinuclear antibodies and proteinuria, but do not develop fatal nephritis. This strain may be useful in dissecting the genetics of systemic lupus erythematosus.
Dr. Brian Kotzin, Amgen Inc.
Genetic Background | Generation |
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000664 C57BL/6J |
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Allele Type | Gene Symbol | Gene Name |
---|---|---|
QTL | Nba10 | New Zealand Black autoimmunity 10 |
Marker Symbol | Marker Name | |
---|---|---|
D1Mit47 | DNA segment, Chr 1, Massachusetts Institute of Technology 47 | |
D1Mit209 | DNA segment, Chr 1, Massachusetts Institute of Technology 209 |
This C57BL/6 strain is homozygous for the age related hearing loss mutation Cdh23ahl, which on this background causes progressive hearing loss with onset after 10 months of age.
Mice homozygous for the NZB/BlNJ-derived lupus susceptibility QTL (Nba2) on the C57BL/6 background develop elevated serum IgG antinuclear antibodies, a two-fold increase in the number of spleen cells (by 10 weeks of age), an increase in the absolute number of B and T cells, early B cell activation, increased levels of IgM, a two-fold increase in activated (CD69+) B cells and a two fold increase in FAS+ B cells. Although approximately 10% of females older than 10 months of age develop high levels of proteinuria, the subsequent nephritis does not result in death. When crossed with NZW/LacJ mice, 95% of F1 hybrid females develop elevated autoantibodies, severe proteinuria and fatal nephritis. This strain may be useful in dissecting the genetics of systemic lupus erythematosus.
This congenic interval, defined by D1Mit47-D1Mit209, was introgressed into C57BL/6J from the donor strain NZB/BlNJ for a minimum of 12 generations and then intercrossed to generate homozygotes. It is maintained by sibling matings. The QTL Nba2 (New Zealand Black autoimmunity 2) is within this interval, and is associated with hypergammaglobulinemia and autoantibody production. The strain was donated to The Jackson Laboratory by Dr. Brian Kotzin in 2007.
Allele Name | NZB |
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Allele Type | QTL |
Allele Synonym(s) | |
Gene Symbol and Name | Nba10, New Zealand Black autoimmunity 10 |
Gene Synonym(s) | |
Strain of Origin | NZB |
Chromosome | 1 |
General Note | This allele shows linkage to increased anti-chromatin and anti-DNA antibodies, increased serum gp70 immune complex levels, and severe glomerulonephritis. |
Molecular Note | This allele confers increased susceptibility to autoimmunity compared to C57BL/6. |
Mutations Made By | Dr. Trine Jorgensen, University of Colorado HSC |
Marker Synonym(s) | |
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Chromosome(s) | 1 |
Marker Synonym(s) | |
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Chromosome(s) | 1 |
When using the B6.NZB-(D1Mit47-D1Mit209)/BkotJ mouse strain in a publication, please cite the originating article(s) and include JAX stock #007716 in your Materials and Methods section.
Facility Barrier Level Descriptions
Service/Product | Description | Price |
---|---|---|
Homozygous, 1 pair minimum |
Frozen Mouse Embryo | B6.NZB-(D1Mit47-D1Mit209)/BkotJ Frozen Embryos | $2595.00 |
Frozen Mouse Embryo | B6.NZB-(D1Mit47-D1Mit209)/BkotJ Frozen Embryos | $2595.00 |
Frozen Mouse Embryo | B6.NZB-(D1Mit47-D1Mit209)/BkotJ Frozen Embryos | $3373.50 |
Frozen Mouse Embryo | B6.NZB-(D1Mit47-D1Mit209)/BkotJ Frozen Embryos | $3373.50 |
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