JAX Mouse Strain Datasheet - 006770

STOCK Rag1^tm1Mom Tg(TIE2GFP)287Sato/J

Stock No:: 006770

Cryo Recovery

Overview

This double mutant mouse strain possessing a Rag1 knock-out and an endothelial expressing green fluorescent protein (GFP) transgene may be useful in studies examining angiogenesis in transplanted tissues.

Donating Investigator

IMR Colony, The Jackson Laboratory

Genetic overview

Genetic Background	Generation

Rag1^tm1Mom

Allele Type	Gene Symbol	Gene Name
Targeted (Null/Knockout)	Rag1	recombination activating gene 1

Tg(TIE2GFP)287Sato

Allele Type
Transgenic (Reporter)

View Genetics

Research Applications

Research Tools
Cancer Research
Hematological Research
Immunology, Inflammation and Autoimmunity Research
Internal/Organ Research

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Base Price

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$2,595.00 Domestic price Cryo Recovery

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Details

Detailed Description

This double mutant strain incorporates Rag1^tm1Mom knock-out from the T and B-cell deficient C.129S7(B6)-Rag1^tm1Mom/J strain (Stock No. 003145) and the endothelial GFP expressing Tg(TIE2GFP)287Sato transgene from the now discontinued B6.Cg-Tg(TIE2GFP)287Sato/1J strain (Stock No, 004659 - refer to STOCK Tg(TIE2GFP)287Sato/J Stock No. 003658).

In an attempt to offer alleles on well-characterized or multiple genetic backgrounds, alleles are frequently moved to a genetic background different from that on which an allele was first characterized. This is the case for the strain above. It should be noted that the phenotype could vary from that originally described for each single mutant. We will modify the strain description if necessary as published results become available.
Of note, this strain does not breed well on the B6 background. The single Tg(TIE2GFP)287Sato transgenic line has a lethal phenotype on the B6 background.

Development

For the Rag1^tm1Mom targeted mutation, a replacement targeting vector with the Pgk-neo marker was used. Homologous recombination of the targeting vector resulted in a 1356 bp deletion in the 5' end of the coding sequence. The 129S7/SvEvBrd AB1 ES cell line was used. The BALB/c congenic strain was generated by Dr. Bob Coffman by backcrossing mice carrying the Rag1^tm1Mom mutation seven times to BALB/cAnNTac inbred mice.

The Tg(TIE2GFP)287Sato transgenic mutation originated on an FVB/N background, and was backcrossed to C57BL/6J for five generations using a speed congenic protocol. The C57BL/6J component of this speed congenic background is estimated at >95% via genome scanning.

To generate this double mutant strain, C.129S7(B6)-Rag1^tm1Mom/J (Stock No. 003145) was crossed to B6.Cg-Tg(TIE2GFP)287Sato/1J (Stock No. 004659 - discontinued. See STOCK Tg(TIE2GFP)287Sato/J, Stock No. 003658).

Expression Data

Expressed Gene	GFP, Green Fluorescent Protein,
Site of Expression	Blood vessel endothelial cells fluoresce green allowing the visualization of all vessels under fluorescent microscopy or purification of endothelial cells by FACS.

Control Suggestions

None Available

Additional Information

Considerations for Choosing Controls

Genetics

Rag1^tm1Mom

Allele Symbol: Rag1^tm1Mom

Allele Name	targeted mutation 1, Peter Mombaerts
Allele Type	Targeted (Null/Knockout)
Allele Synonym(s)	RAG-1-; RAG1^null; Rag-; Rag-1KO; Rag1^-; Rag^1tm1Mom
Gene Symbol and Name	Rag1, recombination activating gene 1
Gene Synonym(s)	RAG-1; RNF74; Rag-1; Rag-1
Site of Expression	expression is seen in bone marrow derived cell lines.
Strain of Origin	129S7/SvEvBrd-Hprt<+>
Chromosome	2
Molecular Note	A 1356 bp genomic fragment of the Rag1 gene, encoding the nuclear localization signal and the zinc-finger motif, was replaced by a neomycin cassette. A mutant transcript expressed from this allele was detected by Northern blot in bone marrow derived cell lines from homozygous mice.
Mutations Made By	Peter Mombaerts, Max Planck Research Unit for Neurogenetics

Tg(TIE2GFP)287Sato

Allele Symbol: Tg(TIE2GFP)287Sato

Allele Name	transgene insertion 287, Thomas N Sato
Allele Type	Transgenic (Reporter)
Allele Synonym(s)	TIE2-GFP; Tg(Tek-GFP)287Sato
Gene Symbol and Name	Tg(TIE2GFP)287Sato, transgene insertion 287, Thomas N Sato
Gene Synonym(s)	TIE2-GFP
Promoter	Tek, endothelial-specific receptor tyrosine kinase, mouse, laboratory
Expressed Gene	GFP, Green Fluorescent Protein,
Site of Expression	Blood vessel endothelial cells fluoresce green allowing the visualization of all vessels under fluorescent microscopy or purification of endothelial cells by FACS.
Strain of Origin	Not Applicable
Chromosome	UN
General Note	Endothelial cells in transgenic mice express GFP, and can be visualized via fluorescent microscopy or purified by FACS.
Molecular Note	The transgene contains Green Fluorescent Protein (GFP) under the control of the endothelial specific receptor tyrosine kinase (Tek, previous symbol Tie2) promoter.
Mutations Made By	Thomas Sato, Nara Institute of Science and Technology

Disease/Phenotype

Disease Terms

Research Areas By Genotype

This mouse can be used to support research in many areas including:

Research Tools
- Cancer Research
  - endothelial cell marker for neovascularization
- Cardiovascular Research
  - endothelial cell marker for neovascularization
- Fluorescent Proteins
- Genetics Research
  - Tissue/Cell Markers
  - Tissue/Cell Markers: endothelial cell markers for neovascularization

Genotype: GFP related

Research Tools
- Fluorescent Proteins

Genotype: Rag1^tm1Mom related

Cancer Research
- Toxicology
  - B and T cell deficiency, xenograft/transplant host
Hematological Research
- Immunological Defects
  - B and T cell deficiency
Immunology, Inflammation and Autoimmunity Research
- Immunodeficiency
  - B and T cell deficiency
- Inflammation
  - B and T cell deficiency
- T Cell Receptor Signaling Defects
  - B and T cell deficiency
Internal/Organ Research
- Lymphoid Tissue Defects
  - B and T cell deficiency
Research Tools
- Cancer Research
  - B and T cell deficiency, xenograft/transplant host
- Toxicology Research
  - xenograft/transplant host

References

Additional - Rag1^tm1Mom related

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Genetic overview

Research Applications

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Detailed Description

Development

Expression Data

Control Suggestions

Additional Information

Rag1tm1Mom

Allele Symbol: Rag1tm1Mom

Tg(TIE2GFP)287Sato

Allele Symbol: Tg(TIE2GFP)287Sato

Disease Terms

Research Areas By Genotype

This mouse can be used to support research in many areas including:

Genotype: GFP related

Genotype: Rag1tm1Mom related

References

Additional - Rag1tm1Mom related

Additional - Tg(TIE2GFP)287Sato related

Genotyping Protocols

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Production of mice from cryopreserved embryos or sperm occurs in a maximum barrier room, G200

Live Mouse

Cryorecovery - Pricing

Progeny testing is not required

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Rag1^tm1Mom

Allele Symbol: Rag1^tm1Mom

Genotype: Rag1^tm1Mom related

Additional - Rag1^tm1Mom related