JAX
Mouse Strain Datasheet - 006137
B6.FVB-Tg(Cdh5-cre)7Mlia/J
Also Known As: VE-Cadherin-Cre (VE-CRE)
Cre expression in these transgenic mice can be seen in the embryo and in adult endothelium of developing and quiescent vessels, as well as in a subset of hematopoietic cells. When bred with mice carrying a loxP-flanked sequence of interest, Cre-mediated recombination will result in deletion of the flanked genome. These mice may be useful in studies of the cardiovascular system.
Donating Investigator
M. Luisa Iruela-Arispe, University of California, Los Angeles
Genetic overview
| Genetic Background | Generation |
|---|---|
|
N12+N2F2
|
Tg(Cdh5-cre)7Mlia
| Allele Type |
|---|
| Transgenic (Recombinase-expressing) |
Research Applications
- Cardiovascular Research
- Developmental Biology Research
- Hematological Research
- Research Tools
Detailed Description
Hemizygotes and homozygotes are viable, fertile, normal in size, and do not display any gross physical or behavioral abnormalities. In the differentiated endothelium transgene expression is observed as early as E7.5 and progresses to almost full penetrance by E14.5. In adult mice, uniform cre expression is observed in the endothelium of developing and quiescent vessels of all organs examined, as well as within a subset of hematopoietic cells. When bred with any mouse containing a loxP-flanked sequence of interest, Cre-mediated recombination will result in deletion of the flanked genome. These mice may be useful in studies of the cardiovascular system, including angiogenesis, and endothelial and hematopoietic cell lineages.
Cre activity is seen in 20%-40% of the fetal liver population and 52% of the adult bone marrow. These mice exhibit less efficient cre-mediated recombination than B6.Cg-Tg(Cdh5-cre)1Spe/J mice (Stock No. 017968), in which cre activity is seen in 85% of the fetal liver population and 96% of adult bone marrow.
View cre expression characterization.
Development
A recombinant vector was designed to place Cre recombinase cDNA downstream from a 2.5-kb fragment of the VE-Cadherin (Cdh5) mouse promoter. This construct was microinjected into FVB/N fertilized oocytes. A selected founder line ("VEN7-CRE") was established and then backcrossed to C57BL/6 for 12 generations prior to sending to The Jackson Laboratory Repository (in 2007). Upon arrival, transgenic mice were bred to C57BL/6J inbred mice (Stock No. 000664) for at least one generation to establish the colony. After this, the colony was maintained for several generations by breeding transgenic mice together.
In 2011, a 32 SNP (single nucleotide polymorphism) panel analysis, with markers covering all 19 chromosomes and the X chromosome, was performed on the rederived living colony at The Jackson Laboratory Repository. This revealed 4 markers that were not C57BL/6 allele-type. Specifically, one marker on chromosome 4 (~20.0 Mbp), two markers on chromosome 8 (~14.8 Mbp and ~15.2 Mbp), and one marker on chromosome 19 (~50.1 Mbp) were homozygous for FVB allele-type. Of note, a marker on chromosome 19 at ~20.5 Mbp is homozygous for C57BL/6 allele-type. These data may suggest possible transgene insertion sites, and/or that the mice were not backcrossed to C57BL/6 for as many generations as originally reported prior to arrival at The Jackson Laboratory Repository.
Expression Data
| Expressed Gene | cre, cre recombinase, bacteriophage P1 |
|---|---|
| Site of Expression | Embryonic and adult expression in endothelium of developing and quiescent vessels of all organs examined, as well as within a subset of hematopoietic cells. |
Control Suggestions
Selected References
- Alva JA; Zovein AC; Monvoisin A; Murphy T; Salazar A; Harvey NL; Carmeliet P; Iruela-Arispe ML. 2006. VE-Cadherin-Cre-recombinase transgenic mouse: A tool for lineage analysis and gene deletion in endothelial cells. Dev Dyn 235(3):759-67. PubMed: 16450386MGI: J:106155
Tg(Cdh5-cre)7Mlia
Allele Symbol: Tg(Cdh5-cre)7Mlia
| Allele Name | transgene insertion 7, M Luisa Iruela-Arispe |
|---|---|
| Allele Type | Transgenic (Recombinase-expressing) |
| Allele Synonym(s) | Tg(Cdh5-cre)1Mlia; VE-Cadherin-Cre; VEC-Cre; VEN7-CRE |
| Gene Symbol and Name | Tg(Cdh5-cre)7Mlia, transgene insertion 7, M Luisa Iruela-Arispe |
| Gene Synonym(s) | Tg(Cdh5-cre)1Mlia; Tg(Cdh5-cre)1Mlia; VE-Cadherin-Cre; VEC-Cre; VEN7-CRE; transgene insertion 1, M Luisa Iruela-Arispe |
| Promoter | Cdh5, cadherin 5, mouse, laboratory |
| Expressed Gene | cre, cre recombinase, bacteriophage P1 |
| Site of Expression | Embryonic and adult expression in endothelium of developing and quiescent vessels of all organs examined, as well as within a subset of hematopoietic cells. |
| Strain of Origin | FVB/N |
| Chromosome | UN |
| Molecular Note | The cadherin 5 promoter was used to drive expression of cre recombinase in the adult epithelium. Three lines were created. |
| Mutations Made By | M. Luisa Iruela-Arispe, University of California, Los Angeles |
Disease Terms
Research Areas By Genotype
This mouse can be used to support research in many areas including:
- Cardiovascular Research
- Vascular Defects
- Developmental Biology Research
- Internal/Organ Defects
- hematopoietic defects
- vasculature
- Internal/Organ Defects
- Hematological Research
- Hematopoietic Defects
- Research Tools
- Cancer Research
- endothelial cell marker for neovascularization
- Cardiovascular Research
- Cre-lox System
- endothelial cell marker for neovascularization
- Cre-lox System
- Cre Recombinase Expression
- Cre Recombinase Expression: Germline/Embryonic Expression
- Developmental Biology Research
- Cre-lox System
- Genetics Research
- Mutagenesis and Transgenesis
- Mutagenesis and Transgenesis: Cre-lox System
- Tissue/Cell Markers
- Tissue/Cell Markers: Cre-lox System
- Tissue/Cell Markers: endothelial cell markers for neovascularization
- Hematological Research
- Cancer Research
Genotype: cre related
- Research Tools
- Cre-lox System
- Genetics Research
- Mutagenesis and Transgenesis
- Mutagenesis and Transgenesis: Cre-lox System
Mammalian Phenotype Terms by Genotype
The following phenotype information is associated with a similar, but not exact match to this JAX® Mice strain
Genotype: Tg(Cdh5-cre)7Mlia/0
involves: FVB/N
normal phenotype
- no abnormal phenotype detected
- mice are viable and fertile; no phenotypic abnormalities are detected (MGI Ref ID J:106155)
References
- Alva JA; Zovein AC; Monvoisin A; Murphy T; Salazar A; Harvey NL; Carmeliet P; Iruela-Arispe ML. 2006. VE-Cadherin-Cre-recombinase transgenic mouse: A tool for lineage analysis and gene deletion in endothelial cells. Dev Dyn 235(3):759-67. PubMed: 16450386MGI: J:106155
Additional - Tg(Cdh5-cre)7Mlia related
- Arsenault PR; Pei F; Lee R; Kerestes H; Percy MJ; Keith B; Simon MC; Lappin TR; Khurana TS; Lee FS. 2013. A Knock-in Mouse Model of Human PHD2 Gene-associated Erythrocytosis Establishes a Haploinsufficiency Mechanism. J Biol Chem 288(47):33571-84. PubMed: 24121508MGI: J:202737
- Bandaru S; Gronros J; Redfors B; Cil C; Pazooki D; Salimi R; Larsson E; Zhou AX; Omerovic E; Akyurek LM. 2015. Deficiency of filamin A in endothelial cells impairs left ventricular remodelling after myocardial infarction. Cardiovasc Res 105(2):151-9. PubMed: 25344364MGI: J:230309
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