JAX
Mouse Strain Datasheet - 006137
B6.FVB-Tg(Cdh5-cre)7Mlia/J
Also Known As: VE-Cadherin-Cre (VE-CRE)
Cre expression in these transgenic mice can be seen in the embryo and in adult endothelium of developing and quiescent vessels, as well as in a subset of hematopoietic cells. When bred with mice carrying a loxP-flanked sequence of interest, Cre-mediated recombination will result in deletion of the flanked genome. These mice may be useful in studies of the cardiovascular system.
Donating Investigator
M. Luisa Iruela-Arispe, University of California, Los Angeles
Genetic overview
| Genetic Background | Generation |
|---|---|
|
N12+N2F2
|
Tg(Cdh5-cre)7Mlia
| Allele Type |
|---|
| Transgenic (Recombinase-expressing) |
Research Applications
- Cardiovascular Research
- Developmental Biology Research
- Hematological Research
- Research Tools
Detailed Description
Hemizygotes and homozygotes are viable, fertile, normal in size, and do not display any gross physical or behavioral abnormalities. In the differentiated endothelium transgene expression is observed as early as E7.5 and progresses to almost full penetrance by E14.5. In adult mice, uniform cre expression is observed in the endothelium of developing and quiescent vessels of all organs examined, as well as within a subset of hematopoietic cells. When bred with any mouse containing a loxP-flanked sequence of interest, Cre-mediated recombination will result in deletion of the flanked genome. These mice may be useful in studies of the cardiovascular system, including angiogenesis, and endothelial and hematopoietic cell lineages.
Cre activity is seen in 20%-40% of the fetal liver population and 52% of the adult bone marrow. These mice exhibit less efficient cre-mediated recombination than B6.Cg-Tg(Cdh5-cre)1Spe/J mice (Stock No. 017968), in which cre activity is seen in 85% of the fetal liver population and 96% of adult bone marrow.
View cre expression characterization.
Development
A recombinant vector was designed to place Cre recombinase cDNA downstream from a 2.5-kb fragment of the VE-Cadherin (Cdh5) mouse promoter. This construct was microinjected into FVB/N fertilized oocytes. A selected founder line ("VEN7-CRE") was established and then backcrossed to C57BL/6 for 12 generations prior to sending to The Jackson Laboratory Repository (in 2007). Upon arrival, transgenic mice were bred to C57BL/6J inbred mice (Stock No. 000664) for at least one generation to establish the colony. After this, the colony was maintained for several generations by breeding transgenic mice together.
In 2011, a 32 SNP (single nucleotide polymorphism) panel analysis, with markers covering all 19 chromosomes and the X chromosome, was performed on the rederived living colony at The Jackson Laboratory Repository. This revealed 4 markers that were not C57BL/6 allele-type. Specifically, one marker on chromosome 4 (~20.0 Mbp), two markers on chromosome 8 (~14.8 Mbp and ~15.2 Mbp), and one marker on chromosome 19 (~50.1 Mbp) were homozygous for FVB allele-type. Of note, a marker on chromosome 19 at ~20.5 Mbp is homozygous for C57BL/6 allele-type. These data may suggest possible transgene insertion sites, and/or that the mice were not backcrossed to C57BL/6 for as many generations as originally reported prior to arrival at The Jackson Laboratory Repository.
Expression Data
| Expressed Gene | cre, cre recombinase, bacteriophage P1 |
|---|---|
| Site of Expression | Embryonic and adult expression in endothelium of developing and quiescent vessels of all organs examined, as well as within a subset of hematopoietic cells. |
Control Suggestions
Selected References
- Alva JA; Zovein AC; Monvoisin A; Murphy T; Salazar A; Harvey NL; Carmeliet P; Iruela-Arispe ML. 2006. VE-Cadherin-Cre-recombinase transgenic mouse: A tool for lineage analysis and gene deletion in endothelial cells.. In: . . MGI: J:106155
Tg(Cdh5-cre)7Mlia
Allele Symbol: Tg(Cdh5-cre)7Mlia
| Allele Name | transgene insertion 7, M Luisa Iruela-Arispe |
|---|---|
| Allele Type | Transgenic (Recombinase-expressing) |
| Allele Synonym(s) | Tg(Cdh5-cre)1Mlia; VE-Cadherin-Cre; VEC-Cre; VEN7-CRE |
| Gene Symbol and Name | Tg(Cdh5-cre)7Mlia, transgene insertion 7, M Luisa Iruela-Arispe |
| Gene Synonym(s) | Tg(Cdh5-cre)1Mlia; Tg(Cdh5-cre)1Mlia; VE-Cadherin-Cre; VEC-Cre; VEN7-CRE; transgene insertion 1, M Luisa Iruela-Arispe |
| Promoter | Cdh5, cadherin 5, mouse, laboratory |
| Expressed Gene | cre, cre recombinase, bacteriophage P1 |
| Site of Expression | Embryonic and adult expression in endothelium of developing and quiescent vessels of all organs examined, as well as within a subset of hematopoietic cells. |
| Strain of Origin | FVB/N |
| Chromosome | UN |
| Molecular Note | The cadherin 5 promoter was used to drive expression of cre recombinase in the adult epithelium. Three lines were created. |
| Mutations Made By | M. Luisa Iruela-Arispe, University of California, Los Angeles |
Disease Terms
Research Areas By Genotype
This mouse can be used to support research in many areas including:
- Cardiovascular Research
- Vascular Defects
- Developmental Biology Research
- Internal/Organ Defects
- hematopoietic defects
- vasculature
- Internal/Organ Defects
- Hematological Research
- Hematopoietic Defects
- Research Tools
- Cancer Research
- endothelial cell marker for neovascularization
- Cardiovascular Research
- Cre-lox System
- endothelial cell marker for neovascularization
- Cre-lox System
- Cre Recombinase Expression
- Cre Recombinase Expression: Germline/Embryonic Expression
- Developmental Biology Research
- Cre-lox System
- Genetics Research
- Mutagenesis and Transgenesis
- Mutagenesis and Transgenesis: Cre-lox System
- Tissue/Cell Markers
- Tissue/Cell Markers: Cre-lox System
- Tissue/Cell Markers: endothelial cell markers for neovascularization
- Hematological Research
- Cancer Research
Genotype: cre related
- Research Tools
- Cre-lox System
- Genetics Research
- Mutagenesis and Transgenesis
- Mutagenesis and Transgenesis: Cre-lox System
Mammalian Phenotype Terms by Genotype
The following phenotype information is associated with a similar, but not exact match to this JAX® Mice strain
Genotype: Tg(Cdh5-cre)7Mlia/0
involves: FVB/N
normal phenotype
- no abnormal phenotype detected
- mice are viable and fertile; no phenotypic abnormalities are detected (MGI Ref ID J:106155)
References
- Alva JA; Zovein AC; Monvoisin A; Murphy T; Salazar A; Harvey NL; Carmeliet P; Iruela-Arispe ML. 2006. VE-Cadherin-Cre-recombinase transgenic mouse: A tool for lineage analysis and gene deletion in endothelial cells.. In: . . MGI: J:106155
Additional - Tg(Cdh5-cre)7Mlia related
- Arsenault PR; Pei F; Lee R; Kerestes H; Percy MJ; Keith B; Simon MC; Lappin TR; Khurana TS; Lee FS. 2013. A Knock-in Mouse Model of Human PHD2 Gene-associated Erythrocytosis Establishes a Haploinsufficiency Mechanism.. In: . . MGI: J:202737
- Bandaru S; Gronros J; Redfors B; Cil C; Pazooki D; Salimi R; Larsson E; Zhou AX; Omerovic E; Akyurek LM. 2015. Deficiency of filamin A in endothelial cells impairs left ventricular remodelling after myocardial infarction.. In: . . MGI: J:230309
- Berry R; Rodeheffer MS. 2013. Characterization of the adipocyte cellular lineage in vivo.. In: . . MGI: J:195198
- Besschetnova TY; Ichimura T; Katebi N; St Croix B; Bonventre JV; Olsen BR. 2015. Regulatory mechanisms of anthrax toxin receptor 1-dependent vascular and connective tissue homeostasis.. In: . . MGI: J:224431
- Briot A; Civelek M; Seki A; Hoi K; Mack JJ; Lee SD; Kim J; Hong C; Yu J; Fishbein GA; Vakili L; Fogelman AM; Fishbein MC; Lusis AJ; Tontonoz P; Navab M; Berliner JA; Iruela-Arispe ML. 2015. Endothelial NOTCH1 is suppressed by circulating lipids and antagonizes inflammation during atherosclerosis.. In: . . MGI: J:229020
- Bryant AJ; Carrick RP; McConaha ME; Jones BR; Shay SD; Moore CS; Blackwell TR; Gladson S; Penner NL; Burman A; Tanjore H; Hemnes AR; Karwandyar AK; Polosukhin VV; Talati MA; Dong HJ; Gleaves LA; Carrier EJ; Gaskill C; Scott EW; Majka SM; Fessel JP; Haase VH; West JD; Blackwell TS; Lawson WE. 2016. Endothelial HIF signaling regulates pulmonary fibrosis-associated pulmonary hypertension.. In: . . MGI: J:233178
- Chang SH; Elemento O; Zhang J; Zhuang ZW; Simons M; Hla T. 2014. ELAVL1 regulates alternative splicing of eIF4E transporter to promote postnatal angiogenesis.. In: . . MGI: J:216804
- Corada M; Nyqvist D; Orsenigo F; Caprini A; Giampietro C; Taketo MM; Iruela-Arispe ML; Adams RH; Dejana E. 2010. The Wnt/beta-catenin pathway modulates vascular remodeling and specification by upregulating Dll4/Notch signaling.. In: . . MGI: J:163848
- Crosswhite PL; Podsiadlowska JJ; Curtis CD; Gao S; Xia L; Srinivasan RS; Griffin CT. 2016. CHD4-regulated plasmin activation impacts lymphovenous hemostasis and hepatic vascular integrity.. In: . . MGI: J:237076
- Das A; Sudhahar V; Chen GF; Kim HW; Youn SW; Finney L; Vogt S; Yang J; Kweon J; Surenkhuu B; Ushio-Fukai M; Fukai T. 2016. Endothelial Antioxidant-1: a Key Mediator of Copper-dependent Wound Healing in vivo.. In: . . MGI: J:236974
- Debruin EJ; Hughes MR; Sina C; Liu A; Cait J; Jian Z; Lopez M; Lo B; Abraham T; McNagny KM. 2014. Podocalyxin regulates murine lung vascular permeability by altering endothelial cell adhesion.. In: . . MGI: J:223453
- Eckle T; Brodsky K; Bonney M; Packard T; Han J; Borchers CH; Mariani TJ; Kominsky DJ; Mittelbronn M; Eltzschig HK. 2013. HIF1A reduces acute lung injury by optimizing carbohydrate metabolism in the alveolar epithelium.. In: . . MGI: J:201805
- Eckle T; Hughes K; Ehrentraut H; Brodsky KS; Rosenberger P; Choi DS; Ravid K; Weng T; Xia Y; Blackburn MR; Eltzschig HK. 2013. Crosstalk between the equilibrative nucleoside transporter ENT2 and alveolar Adora2b adenosine receptors dampens acute lung injury.. In: . . MGI: J:203572
- Economopoulou M; Langer HF; Celeste A; Orlova VV; Choi EY; Ma M; Vassilopoulos A; Callen E; Deng C; Bassing CH; Boehm M; Nussenzweig A; Chavakis T. 2009. Histone H2AX is integral to hypoxia-driven neovascularization.. In: . . MGI: J:149487
- Fahs SA; Hille MT; Shi Q; Weiler H; Montgomery RR. 2014. A conditional knockout mouse model reveals endothelial cells as the principal and possibly exclusive source of plasma factor VIII.. In: . . MGI: J:212401
- Fioret BA; Heimfeld JD; Paik DT; Hatzopoulos AK. 2014. Endothelial Cells Contribute to Generation of Adult Ventricular Myocytes during Cardiac Homeostasis.. In: . . MGI: J:212071
- Fulgenzi G; Tomassoni-Ardori F; Babini L; Becker J; Barrick C; Puverel S; Tessarollo L. 2015. BDNF modulates heart contraction force and long-term homeostasis through truncated TrkB.T1 receptor activation.. In: . . MGI: J:227509
- Gandhirajan RK; Meng S; Chandramoorthy HC; Mallilankaraman K; Mancarella S; Gao H; Razmpour R; Yang XF; Houser SR; Chen J; Koch WJ; Wang H; Soboloff J; Gill DL; Madesh M. 2013. Blockade of NOX2 and STIM1 signaling limits lipopolysaccharide-induced vascular inflammation.. In: . . MGI: J:194484
- Genetic Resource Science at The Jackson Laboratory. 2008. Expression/Specificity Patterns of Cre Alleles. In: . . MGI: J:137887
- Genetic Resource Science at The Jackson Laboratory. 2012. Expression/Specificity Patterns of Cre Alleles, 2011. In: . . MGI: J:184578
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- Greif DM; Kumar M; Lighthouse JK; Hum J; An A; Ding L; Red-Horse K; Espinoza FH; Olson L; Offermanns S; Krasnow MA. 2012. Radial construction of an arterial wall.. In: . . MGI: J:189012
- Guo W; Lasky JL; Chang CJ; Mosessian S; Lewis X; Xiao Y; Yeh JE; Chen JY; Iruela-Arispe ML; Varella-Garcia M; Wu H. 2008. Multi-genetic events collaboratively contribute to Pten-null leukaemia stem-cell formation.. In: . . MGI: J:135172
- Guo W; Schubbert S; Chen JY; Valamehr B; Mosessian S; Shi H; Dang NH; Garcia C; Theodoro MF; Varella-Garcia M; Wu H. 2011. Suppression of leukemia development caused by PTEN loss.. In: . . MGI: J:168259
- Harel I; Nathan E; Tirosh-Finkel L; Zigdon H; Guimaraes-Camboa N; Evans SM; Tzahor E. 2009. Distinct origins and genetic programs of head muscle satellite cells.. In: . . MGI: J:150129
- Hofmann JJ; Briot A; Enciso J; Zovein AC; Ren S; Zhang ZW; Radtke F; Simons M; Wang Y; Iruela-Arispe ML. 2012. Endothelial deletion of murine Jag1 leads to valve calcification and congenital heart defects associated with Alagille syndrome.. In: . . MGI: J:189213
- Hofmann JJ; Zovein AC; Koh H; Radtke F; Weinmaster G; Iruela-Arispe ML. 2010. Jagged1 in the portal vein mesenchyme regulates intrahepatic bile duct development: insights into Alagille syndrome.. In: . . MGI: J:166890
- Hu K; Olsen BR. 2016. Osteoblast-derived VEGF regulates osteoblast differentiation and bone formation during bone repair.. In: . . MGI: J:231165
- Ji W; Li Y; He Y; Yin M; Zhou HJ; Boggon TJ; Zhang H; Min W. 2015. AIP1 Expression in Tumor Niche Suppresses Tumor Progression and Metastasis.. In: . . MGI: J:225590
- Kanisicak O; Khalil H; Ivey MJ; Karch J; Maliken BD; Correll RN; Brody MJ; J Lin SC; Aronow BJ; Tallquist MD; Molkentin JD. 2016. Genetic lineage tracing defines myofibroblast origin and function in the injured heart.. In: . . MGI: J:241168
- Kapitsinou PP; Rajendran G; Astleford L; Michael M; Schonfeld MP; Fields T; Shay S; French JL; West J; Haase VH. 2016. The Endothelial Prolyl-4-Hydroxylase Domain 2/Hypoxia-Inducible Factor 2 Axis Regulates Pulmonary Artery Pressure in Mice.. In: . . MGI: J:236191
- Kapitsinou PP; Sano H; Michael M; Kobayashi H; Davidoff O; Bian A; Yao B; Zhang MZ; Harris RC; Duffy KJ; Erickson-Miller CL; Sutton TA; Haase VH. 2014. Endothelial HIF-2 mediates protection and recovery from ischemic kidney injury.. In: . . MGI: J:212930
- Koo Y; Barry DM; Xu K; Tanigaki K; Davis GE; Mineo C; Cleaver O. 2016. Rasip1 is essential to blood vessel stability and angiogenic blood vessel growth.. In: . . MGI: J:241190
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- Lee CL; Moding EJ; Cuneo KC; Li Y; Sullivan JM; Mao L; Washington I; Jeffords LB; Rodrigues RC; Ma Y; Das S; Kontos CD; Kim Y; Rockman HA; Kirsch DG. 2012. p53 functions in endothelial cells to prevent radiation-induced myocardial injury in mice.. In: . . MGI: J:231124
- Lee S; Chen TT; Barber CL; Jordan MC; Murdock J; Desai S; Ferrara N; Nagy A; Roos KP; Iruela-Arispe ML. 2007. Autocrine VEGF signaling is required for vascular homeostasis.. In: . . MGI: J:124900
- Li Z; Lan Y; He W; Chen D; Wang J; Zhou F; Wang Y; Sun H; Chen X; Xu C; Li S; Pang Y; Zhang G; Yang L; Zhu L; Fan M; Shang A; Ju Z; Luo L; Ding Y; Guo W; Yuan W; Yang X; Liu B. 2012. Mouse embryonic head as a site for hematopoietic stem cell development.. In: . . MGI: J:193721
- Liang M; Woodard LE; Liang A; Luo J; Wilson MH; Mitch WE; Cheng J. 2015. Protective Role of Insulin-Like Growth Factor-1 Receptor in Endothelial Cells against Unilateral Ureteral Obstruction-Induced Renal Fibrosis.. In: . . MGI: J:220729
- Liu S; Liu J; Ma Q; Cao L; Fattah RJ; Yu Z; Bugge TH; Finkel T; Leppla SH. 2016. Solid tumor therapy by selectively targeting stromal endothelial cells.. In: . . MGI: J:234402
- Liu S; Zhang Y; Moayeri M; Liu J; Crown D; Fattah RJ; Wein AN; Yu ZX; Finkel T; Leppla SH. 2013. Key tissue targets responsible for anthrax-toxin-induced lethality.. In: . . MGI: J:205421
- Lucitti JL; Mackey JK; Morrison JC; Haigh JJ; Adams RH; Faber JE. 2012. Formation of the collateral circulation is regulated by vascular endothelial growth factor-A and a disintegrin and metalloprotease family members 10 and 17.. In: . . MGI: J:212884
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- McBride SH; McKenzie JA; Bedrick BS; Kuhlmann P; Pasteris JD; Rosen V; Silva MJ. 2014. Long bone structure and strength depend on BMP2 from osteoblasts and osteocytes, but not vascular endothelial cells.. In: . . MGI: J:216332
- McBride-Gagyi SH; McKenzie JA; Buettmann EG; Gardner MJ; Silva MJ. 2015. Bmp2 conditional knockout in osteoblasts and endothelial cells does not impair bone formation after injury or mechanical loading in adult mice.. In: . . MGI: J:228433
- Moding EJ; Lee CL; Castle KD; Oh P; Mao L; Zha S; Min HD; Ma Y; Das S; Kirsch DG. 2014. Atm deletion with dual recombinase technology preferentially radiosensitizes tumor endothelium.. In: . . MGI: J:215614
- Monvoisin A; Alva JA; Hofmann JJ; Zovein AC; Lane TF; Iruela-Arispe ML. 2006. VE-cadherin-CreERT2 transgenic mouse: a model for inducible recombination in the endothelium.. In: . . MGI: J:116638
- Myers SA; DeVries WH; Andres KR; Gruenthal MJ; Benton RL; Hoying JB; Hagg T; Whittemore SR. 2011. CD47 knockout mice exhibit improved recovery from spinal cord injury.. In: . . MGI: J:170731
- Nakamura-Ishizu A; Takubo K; Kobayashi H; Suzuki-Inoue K; Suda T. 2015. CLEC-2 in megakaryocytes is critical for maintenance of hematopoietic stem cells in the bone marrow.. In: . . MGI: J:229021
- Nie L; Guo X; Esmailzadeh L; Zhang J; Asadi A; Collinge M; Li X; Kim JD; Woolls M; Jin SW; Dubrac A; Eichmann A; Simons M; Bender JR; Sadeghi MM. 2013. Transmembrane protein ESDN promotes endothelial VEGF signaling and regulates angiogenesis.. In: . . MGI: J:207629
- Nitschke M; Aebischer D; Abadier M; Haener S; Lucic M; Vigl B; Luche H; Fehling HJ; Biehlmaier O; Lyck R; Halin C. 2012. Differential requirement for ROCK in dendritic cell migration within lymphatic capillaries in steady-state and inflammation.. In: . . MGI: J:191311
- Okuno Y; Nakamura-Ishizu A; Otsu K; Suda T; Kubota Y. 2012. Pathological neoangiogenesis depends on oxidative stress regulation by ATM.. In: . . MGI: J:192791
- Onder L; Danuser R; Scandella E; Firner S; Chai Q; Hehlgans T; Stein JV; Ludewig B. 2013. Endothelial cell-specific lymphotoxin-beta receptor signaling is critical for lymph node and high endothelial venule formation.. In: . . MGI: J:196703
- Osmanagic-Myers S; Rus S; Wolfram M; Brunner D; Goldmann WH; Bonakdar N; Fischer I; Reipert S; Zuzuarregui A; Walko G; Wiche G. 2015. Plectin reinforces vascular integrity by mediating crosstalk between the vimentin and the actin networks.. In: . . MGI: J:234446
- Pasula S; Cai X; Dong Y; Messa M; McManus J; Chang B; Liu X; Zhu H; Mansat RS; Yoon SJ; Hahn S; Keeling J; Saunders D; Ko G; Knight J; Newton G; Luscinskas F; Sun X; Towner R; Lupu F; Xia L; Cremona O; De Camilli P; Min W; Chen H. 2012. Endothelial epsin deficiency decreases tumor growth by enhancing VEGF signaling.. In: . . MGI: J:193966
- Pitt LA; Tikhonova AN; Hu H; Trimarchi T; King B; Gong Y; Sanchez-Martin M; Tsirigos A; Littman DR; Ferrando AA; Morrison SJ; Fooksman DR; Aifantis I; Schwab SR. 2015. CXCL12-Producing Vascular Endothelial Niches Control Acute T Cell Leukemia Maintenance.. In: . . MGI: J:222919
- Poulos MG; Guo P; Kofler NM; Pinho S; Gutkin MC; Tikhonova A; Aifantis I; Frenette PS; Kitajewski J; Rafii S; Butler JM. 2013. Endothelial Jagged-1 is necessary for homeostatic and regenerative hematopoiesis.. In: . . MGI: J:202842
- Qiao L; Nishimura T; Shi L; Sessions D; Thrasher A; Trudell JR; Berry GJ; Pearl RG; Kao PN. 2014. Endothelial fate mapping in mice with pulmonary hypertension.. In: . . MGI: J:231994
- Ramo K; Sugamura K; Craige S; Keaney JF; Davis RJ. 2016. Suppression of ischemia in arterial occlusive disease by JNK-promoted native collateral artery development.. In: . . MGI: J:235606
- Red-Horse K; Ueno H; Weissman IL; Krasnow MA. 2010. Coronary arteries form by developmental reprogramming of venous cells.. In: . . MGI: J:158886
- Roodhart JM; He H; Daenen LG; Monvoisin A; Barber CL; van Amersfoort M; Hofmann JJ; Radtke F; Lane TF; Voest EE; Iruela-Arispe ML. 2013. Notch1 regulates angio-supportive bone marrow-derived cells in mice: relevance to chemoresistance.. In: . . MGI: J:201006
- Roth Flach RJ; Guo CA; Danai LV; Yawe JC; Gujja S; Edwards YJ; Czech MP. 2016. Endothelial Mitogen-Activated Protein Kinase Kinase Kinase Kinase 4 Is Critical for Lymphatic Vascular Development and Function.. In: . . MGI: J:236186
- Roth Flach RJ; Skoura A; Matevossian A; Danai LV; Zheng W; Cortes C; Bhattacharya SK; Aouadi M; Hagan N; Yawe JC; Vangala P; Menendez LG; Cooper MP; Fitzgibbons TP; Buckbinder L; Czech MP. 2015. Endothelial protein kinase MAP4K4 promotes vascular inflammation and atherosclerosis.. In: . . MGI: J:239995
- Ruiz-Herguido C; Guiu J; D'Altri T; Ingles-Esteve J; Dzierzak E; Espinosa L; Bigas A. 2012. Hematopoietic stem cell development requires transient Wnt/beta-catenin activity.. In: . . MGI: J:189158
- Satyanarayana A; Gudmundsson KO; Chen X; Coppola V; Tessarollo L; Keller JR; Hou SX. 2010. RapGEF2 is essential for embryonic hematopoiesis but dispensable for adult hematopoiesis.. In: . . MGI: J:165879
- Schubbert S; Cardenas A; Chen H; Garcia C; Guo W; Bradner J; Wu H. 2014. Targeting the MYC and PI3K pathways eliminates leukemia-initiating cells in T-cell acute lymphoblastic leukemia.. In: . . MGI: J:217184
- Shao L; Zhou HJ; Zhang H; Qin L; Hwa J; Yun Z; Ji W; Min W. 2015. SENP1-mediated NEMO deSUMOylation in adipocytes limits inflammatory responses and type-1 diabetes progression.. In: . . MGI: J:228009
- Shatat MA; Tian H; Zhang R; Tandon G; Hale A; Fritz JS; Zhou G; Martinez-Gonzalez J; Rodriguez C; Champion HC; Jain MK; Hamik A. 2014. Endothelial Kruppel-like factor 4 modulates pulmonary arterial hypertension.. In: . . MGI: J:232093
- Shoham AB; Malkinson G; Krief S; Shwartz Y; Ely Y; Ferrara N; Yaniv K; Zelzer E. 2012. S1P1 inhibits sprouting angiogenesis during vascular development.. In: . . MGI: J:187683
- Skuli N; Liu L; Runge A; Wang T; Yuan L; Patel S; Iruela-Arispe L; Simon MC; Keith B. 2009. Endothelial deletion of hypoxia-inducible factor-2alpha (HIF-2alpha) alters vascular function and tumor angiogenesis.. In: . . MGI: J:150753
- Skuli N; Majmundar AJ; Krock BL; Mesquita RC; Mathew LK; Quinn ZL; Runge A; Liu L; Kim MN; Liang J; Schenkel S; Yodh AG; Keith B; Simon MC. 2012. Endothelial HIF-2alpha regulates murine pathological angiogenesis and revascularization processes.. In: . . MGI: J:184551
- Soni D; Regmi SC; Wang DM; DebRoy A; Zhao YY; Vogel SM; Malik AB; Tiruppathi C. 2017. Pyk2 phosphorylation of VE-PTP downstream of STIM1-induced Ca2+ entry regulates disassembly of adherens junctions.. In: . . MGI: J:243304
- Soveg F; Abdala-Valencia H; Campbell J; Morales-Nebreda L; Mutlu GM; Cook-Mills JM. 2015. Regulation of allergic lung inflammation by endothelial cell transglutaminase 2.. In: . . MGI: J:232520
- Tang Y; Bai H; Urs S; Wang Z; Liaw L. 2013. Notch1 activation in embryonic VE-cadherin populations selectively blocks hematopoietic stem cell generation and fetal liver hematopoiesis.. In: . . MGI: J:212513
- Tang Y; Harrington A; Yang X; Friesel RE; Liaw L. 2010. The contribution of the Tie2+ lineage to primitive and definitive hematopoietic cells.. In: . . MGI: J:170016
- Tomar D; Dong Z; Shanmughapriya S; Koch DA; Thomas T; Hoffman NE; Timbalia SA; Goldman SJ; Breves SL; Corbally DP; Nemani N; Fairweather JP; Cutri AR; Zhang X; Song J; Jana F; Huang J; Barrero C; Rabinowitz JE; Luongo TS; Schumacher SM; Rockman ME; Dietrich A; Merali S; Caplan J; Stathopulos P; Ahima RS; Cheung JY; Houser SR; Koch WJ; Patel V; Gohil VM; Elrod JW; Rajan S; Madesh M. 2016. MCUR1 Is a Scaffold Factor for the MCU Complex Function and Promotes Mitochondrial Bioenergetics.. In: . . MGI: J:235756
- Torisu K; Singh KK; Torisu T; Lovren F; Liu J; Pan Y; Quan A; Ramadan A; Al-Omran M; Pankova N; Boyd SR; Verma S; Finkel T. 2016. Intact endothelial autophagy is required to maintain vascular lipid homeostasis.. In: . . MGI: J:231633
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