DDD.GR-Mtv2^a/JmsJ

Stock number: 006132
Product name: DDD-Mtv-2
Strain synonyms: DDD/1-Mtv-2/Mtv-2
Research areas: Cancer Research

Description

These congenic mice carry the Mtv2^a allele from the inbred strain GR on the DDD/1 genetic background and develop mammary tumors at a lower incidence than the GR strain.

Detailed description

About 80% of breeding DDD-Mtv-2 females develop mammary tumors. The tumor incidence is lower and the tumor age higher than those in GR mice (Stock No. 006131), suggesting less active functioning of the gene on the DDD genetic background. About 70% of these tumors were morphologically classified as pale cell and type P carcinomas peculiar to GR mice. Development of mammary plaques characterized by ductal hyperplasias has an incidence of 48.0% with most of the positive mice (75.3%) having only one plaque. The DDD-Mtv-2-strain may be useful for biological and molecular research into mouse mammary tumorigenesis.

Development

The DDD strain originated in Germany and was transferred to Kitasato Institute in Japan in 1928. Inbreeding began at Denken (now the Institute of Medical Science at the University of Tokyo) in 1957 and was completed in 1962. The strain is described as DDD -"deutsche maus at Denken". This congenic was generated by introgressing the Mtv2 allele from the inbred strain GR into DDD/1 mice for a minimum of 12 generations (Matsuzawa A, et al, 1990). DDD/1 is a substrain of DDD that exhibits a different isozyme pattern at Idh1 (Tanaka S, et al, 1987). The history of this particular colony can be traced to Dr. Sayama at Shizuoka University who received the colony from the University of Tokyo prior to 1990. The colony was imported from Japan in 2001 by Sagres Discovery and maintained as a private colony at The Jackson Laboratory. It was donated to The Jackson Laboratory Repository in 2006.

Allele

Symbol: Mtv2^a
Name: mammary tumor virus locus 2, present
MGI accession ID: MGI:3579297
Generation method: Not Applicable
Marker symbol: Mtv2
Marker name: mammary tumor virus locus 2
Marker synonyms: Mtv-2
Chromosome: 18
Strain of origin: Not Applicable
General note: The provirus is present in the following strains: GR/Imr, GR, and SHN/Mei.