JAX Mouse Strain Datasheet - 005973

C3Bir.129P2(B6)-Il10^C3Bir/LtJ

Stock No:: 005973 |; IL10T

Congenic

Cryo Recovery

Overview

Also Known As: IL10T

This is a control strain for C3Bir.129P2(B6)-Il10^tm1Cgn/LtJ (Stock No. 003968); it does not exhibit the Il10-deficient phenotype.

Genetic overview

Genetic Background	Generation
C3H/HeJBirLt

Tlr4^Lps-d

Allele Type	Gene Symbol	Gene Name
Spontaneous	Tlr4	toll-like receptor 4

Marker(s)

	Marker Symbol	Marker Name
	Il10	interleukin 10

View Genetics

Research Applications

Immunology, Inflammation and Autoimmunity Research

View All Research Applications

Base Price

Starting at:

$2,595.00 Domestic price Cryo Recovery

View Price List

Details

Important Note

This strain is homozygous for Pde6b^rd1 and Tlr4^Lps-d.

Detailed Description

This is a control strain for C3Bir.129P2(B6)-Il10^tm1Cgn/LtJ (Stock No. 003968); it does not exhibit the Il10-deficient phenotype.

Development

This is a control strain for the Il10 knock-out strain, C3Bir.129P2(B6)-Il10^tm1Cgn/LtJ (originally Stock No. 4326 that is now extinct); superseded by Stock No. 003968), and was developed in parallel with the mutant strain until backcrossing was complete.

The Il10^tm1Cgn knock-out mutation was created by in the Laboratory of Dr. Werner Muller at the University of Cologne. Briefly, a targeting vector was designed to replace codons 5-55 of exon 1 of the targeted gene with a 24 bp linker (providing a termination codon) and a neo expression cassette, as well as introduce a termination codon into exon 3. The construct was electroporated into 129P2/OlaHsd-derived E14-1 embryonic stem (ES) cells. Correctly targeted ES cells were injected into recipient C57BL/6 blastocysts and chimeric males were bred with C57BL/6 females to establish the mutant colony on a mixed B6;129P2 genetic background. It was then imported to the Induced Mutant Resource at The Jackson Laboratory in 1995. Subsequently, mutant mice were backcrossed to the C3H/HeJBirLt host strain for at least 10 generations. At the tenth backcross generation, heterozygotes were intercrossed to produce founders for the homozygous C3Bir.129P2(B6)-Il10^tm1Cgn/Lt mutant line as well as founders for this wildtype control line (Stock No. 005973). This strain was imported into The Jackson Laboratory Repository at N15F15 from the research laboratory of Dr. Ed Leiter in 2006.

Control Suggestions

This strain is a control for 004326 and 003968.

Additional Information

Considerations for Choosing Controls

Genetics

Tlr4^Lps-d

Allele Symbol: Tlr4^Lps-d

Allele Name	defective lipopolysaccharide response
Allele Type	Spontaneous
Allele Synonym(s)	TLR4-M; TLR4-Mu; TLR4^lps-def; TLR4d; Tlr4^-; Tlr4^d; Tlr^Lps-d; lps^d; mutant TLR4
Gene Symbol and Name	Tlr4, toll-like receptor 4
Gene Synonym(s)	ARMD10; CD284; Lps; Lps; RAS-like, family 2, locus 8; Rasl2-8; Rasl2-8; TLR-4; TOLL; lipopolysaccharide response; lipopolysaccharide response
Strain of Origin	C3H/HeJ
Chromosome	4
General Note	C3H/HeJ mice carry this allele. Various combinations of Lps-associated traits have been followed in crosses between C3H/HeJ and other C3H substrains, and the traits have in all cases segregated together (J:30692, J:5557, J:5593, J:5938). Some of the traits show dominance of the Tlr4^lps-n allele; others, including Tlr4^Lps-d, show codominance. Genbank ID for this allele: AF095353
Molecular Note	This allele corresponds to a mutation in the third exon of the gene. A C to A substitution at nucleotide position 2342 results in an amino acid substitution that replaces proline with histidine at position 712.

Il10

Marker Symbol: Il10

Marker Synonym(s)	CSIF; GVHDS; IL-10; IL10A; IL10X; Il-10; TGIF; cytokine synthesis inhibitory factor
Chromosome(s)	1

Disease/Phenotype

Disease Terms

Research Areas By Genotype

This mouse can be used to support research in many areas including:

Immunology, Inflammation and Autoimmunity Research
- Inflammation
  - control strain

Genotype: Tlr4^Lps-d related

Immunology, Inflammation and Autoimmunity Research
- CD Antigens, Antigen Receptors, and Histocompatibility Markers
  - Tlr deficiency
- Immunodeficiency
  - Tlr deficiency
- Inflammation
  - Tlr deficiency

References

Additional - Tlr4^Lps-d related

Abel B; Thieblemont N; Quesniaux VJ; Brown N; Mpagi J; Miyake K; Bihl F; Ryffel B. 2002. Toll-like receptor 4 expression is required to control chronic Mycobacterium tuberculosis infection in mice. J Immunol 169(6):3155-62. PubMed: 12218133 MGI: J:78959
Agrawal V; Jaiswal MK; Ilievski V; Beaman KD; Jilling T; Hirsch E. 2014. Platelet-activating factor: a role in preterm delivery and an essential interaction with Toll-like receptor signaling in mice. Biol Reprod 91(5):119. PubMed: 25253732 MGI: J:218423
An CH; Wang XM; Lam HC; Ifedigbo E; Washko GR; Ryter SW; Choi AM. 2012. TLR4 deficiency promotes autophagy during cigarette smoke-induced pulmonary emphysema. Am J Physiol Lung Cell Mol Physiol 303(9):L748-57. PubMed: 22983353 MGI: J:193661
Andonegui G; Bonder CS; Green F; Mullaly SC; Zbytnuik L; Raharjo E; Kubes P. 2003. Endothelium-derived Toll-like receptor-4 is the key molecule in LPS-induced neutrophil sequestration into lungs. J Clin Invest 111(7):1011-20. PubMed: 12671050 MGI: J:82623
Andonegui G; Goyert SM; Kubes P. 2002. Lipopolysaccharide-induced leukocyte-endothelial cell interactions: a role for CD14 versus toll-like receptor 4 within microvessels. J Immunol 169(4):2111-9. PubMed: 12165539 MGI: J:120701
Apte RN; Ascher O; Pluznik DH. 1977. Relationship between lipopolysaccharide-induced serum colony stimulating factor and interferon in regulation of murine granulopoiesis Exp Hematol 5(Suppl 2):12 (Abstr.). MGI: J:30692
Arizmendi NG; Abel M; Mihara K; Davidson C; Polley D; Nadeem A; El Mays T; Gilmore BF; Walker B; Gordon JR; Hollenberg MD; Vliagoftis H. 2011. Mucosal allergic sensitization to cockroach allergens is dependent on proteinase activity and proteinase-activated receptor-2 activation. J Immunol 186(5):3164-72. PubMed: 21270400 MGI: J:169393
Askenase PW; Itakura A; Leite-de-Moraes MC; Lisbonne M; Roongapinun S; Goldstein DR; Szczepanik M. 2005. TLR-dependent IL-4 production by invariant Valpha14+Jalpha18+ NKT cells to initiate contact sensitivity in vivo. J Immunol 175(10):6390-401. PubMed: 16272291 MGI: J:119381
Babcock AA; Toft-Hansen H; Owens T. 2008. Signaling through MyD88 regulates leukocyte recruitment after brain injury. J Immunol 181(9):6481-90. PubMed: 18941239 MGI: J:140719
Babcock AA; Wirenfeldt M; Holm T; Nielsen HH; Dissing-Olesen L; Toft-Hansen H; Millward JM; Landmann R; Rivest S; Finsen B; Owens T. 2006. Toll-like receptor 2 signaling in response to brain injury: an innate bridge to neuroinflammation. J Neurosci 26(49):12826-37. PubMed: 17151286 MGI: J:116760
Babelova A; Moreth K; Tsalastra-Greul W; Zeng-Brouwers J; Eickelberg O; Young MF; Bruckner P; Pfeilschifter J; Schaefer RM; Grone HJ; Schaefer L. 2009. Biglycan, a danger signal that activates the NLRP3 inflammasome via toll-like and P2X receptors. J Biol Chem 284(36):24035-48. PubMed: 19605353 MGI: J:155256
Bachmaier K; Toya S; Malik AB. 2014. Therapeutic administration of the chemokine CXCL1/KC abrogates autoimmune inflammatory heart disease. PLoS One 9(2):e89647. PubMed: 24586934 MGI: J:214482
Bandukwala HS; Clay BS; Tong J; Mody PD; Cannon JL; Shilling RA; Verbeek JS; Weinstock JV; Solway J; Sperling AI. 2007. Signaling through Fc gamma RIII is required for optimal T helper type (Th)2 responses and Th2-mediated airway inflammation. J Exp Med 204(8):1875-89. PubMed: 17664287 MGI: J:125951
Barber SA; Perera PY; Vogel SN. 1995. Defective ceramide response in C3H/HeJ (Lpsd) macrophages. J Immunol 155(5):2303-5. PubMed: 7650365 MGI: J:28193
Barrett TJ; Potter ME; Strockbine NA. 1990. Evidence for participation of the macrophage in Shiga-like toxin II-induced lethality in mice. Microb Pathog 9(2):95-103. PubMed: 2277589 MGI: J:25812
Barsness KA; Arcaroli J; Harken AH; Abraham E; Banerjee A; Reznikov L; McIntyre RC. 2004. Hemorrhage-induced acute lung injury is TLR-4 dependent. Am J Physiol Regul Integr Comp Physiol 287(3):R592-9. PubMed: 15072965 MGI: J:95788
Basu S; Kang TJ; Chen WH; Fenton MJ; Baillie L; Hibbs S; Cross AS. 2007. Role of Bacillus anthracis spore structures in macrophage cytokine responses. Infect Immun 75(5):2351-8. PubMed: 17339355 MGI: J:121885
Bauer AK; Dixon D; DeGraff LM; Cho HY; Walker CR; Malkinson AM; Kleeberger SR. 2005. Toll-like receptor 4 in butylated hydroxytoluene-induced mouse pulmonary inflammation and tumorigenesis. J Natl Cancer Inst 97(23):1778-81. PubMed: 16333033 MGI: J:104658
Baumgarten G; Knuefermann P; Nozaki N; Sivasubramanian N; Mann DL; Vallejo JG. 2001. In vivo expression of proinflammatory mediators in the adult heart after endotoxin administration: the role of toll-like receptor-4. J Infect Dis 183(11):1617-24. PubMed: 11343210 MGI: J:120520
Benjamin JT; Carver BJ; Plosa EJ; Yamamoto Y; Miller JD; Liu JH; van der Meer R; Blackwell TS; Prince LS. 2010. NF-kappaB activation limits airway branching through inhibition of Sp1-mediated fibroblast growth factor-10 expression. J Immunol 185(8):4896-903. PubMed: 20861353 MGI: J:164723
Berguer PM; Mundinano J; Piazzon I; Goldbaum FA. 2006. A polymeric bacterial protein activates dendritic cells via TLR4. J Immunol 176(4):2366-72. PubMed: 16455994 MGI: J:129193
Bhan U; Ballinger MN; Zeng X; Newstead MJ; Cornicelli MD; Standiford TJ. 2010. Cooperative interactions between TLR4 and TLR9 regulate interleukin 23 and 17 production in a murine model of gram negative bacterial pneumonia. PLoS One 5(3):e9896. PubMed: 20360853 MGI: J:158954
Bhattacharyya S; Kelley K; Melichian DS; Tamaki Z; Fang F; Su Y; Feng G; Pope RM; Budinger GR; Mutlu GM; Lafyatis R; Radstake T; Feghali-Bostwick C; Varga J. 2013. Toll-like receptor 4 signaling augments transforming growth factor-beta responses: a novel mechanism for maintaining and amplifying fibrosis in scleroderma. Am J Pathol 182(1):192-205. PubMed: 23141927 MGI: J:192234
Bou Ghanem EN; McElroy DS; D'Orazio SE. 2009. Multiple mechanisms contribute to the robust rapid gamma interferon response by CD8+ T cells during Listeria monocytogenes infection. Infect Immun 77(4):1492-501. PubMed: 19179413 MGI: J:147169
Braedel S; Radsak M; Einsele H; Latge JP; Michan A; Loeffler J; Haddad Z; Grigoleit U; Schild H; Hebart H. 2004. Aspergillus fumigatus antigens activate innate immune cells via toll-like receptors 2 and 4. Br J Haematol 125(3):392-9. PubMed: 15086422 MGI: J:89264
Branger J; Knapp S; Weijer S; Leemans JC; Pater JM; Speelman P; Florquin S; van der Poll T. 2004. Role of Toll-like receptor 4 in gram-positive and gram-negative pneumonia in mice. Infect Immun 72(2):788-94. PubMed: 14742522 MGI: J:87807
Buchholz BM; Billiar TR; Bauer AJ. 2010. Dominant role of the MyD88-dependent signaling pathway in mediating early endotoxin-induced murine ileus. Am J Physiol Gastrointest Liver Physiol 299(2):G531-8. PubMed: 20508155 MGI: J:163354
Buchholz BM; Chanthaphavong RS; Bauer AJ. 2009. Nonhemopoietic cell TLR4 signaling is critical in causing early lipopolysaccharide-induced ileus. J Immunol 183(10):6744-53. PubMed: 19846874 MGI: J:157181
Bunt SK; Clements VK; Hanson EM; Sinha P; Ostrand-Rosenberg S. 2009. Inflammation enhances myeloid-derived suppressor cell cross-talk by signaling through Toll-like receptor 4. J Leukoc Biol 85(6):996-1004. PubMed: 19261929 MGI: J:149766
Burch LH; Yang IV; Whitehead GS; Chao FG; Berman KG; Schwartz DA. 2006. The transcriptional response to lipopolysaccharide reveals a role for interferon-gamma in lung neutrophil recruitment. Am J Physiol Lung Cell Mol Physiol 291(4):L677-82. PubMed: 16766576 MGI: J:144404
Cabanski M; Steinmuller M; Marsh LM; Surdziel E; Seeger W; Lohmeyer J. 2008. PKR regulates TLR2/TLR4-dependent signaling in murine alveolar macrophages. Am J Respir Cell Mol Biol 38(1):26-31. PubMed: 17690330 MGI: J:142999
Campos MA; Rosinha GM; Almeida IC; Salgueiro XS; Jarvis BW; Splitter GA; Qureshi N; Bruna-Romero O; Gazzinelli RT; Oliveira SC. 2004. Role of Toll-like receptor 4 in induction of cell-mediated immunity and resistance to Brucella abortus infection in mice. Infect Immun 72(1):176-86. PubMed: 14688095 MGI: J:87836
Canale-Zambrano JC; Auger ML; Haston CK. 2010. Toll-like receptor-4 genotype influences the survival of cystic fibrosis mice. Am J Physiol Gastrointest Liver Physiol 299(2):G381-90. PubMed: 20522639 MGI: J:163347
Cao CX; Yang QW; Lv FL; Cui J; Fu HB; Wang JZ. 2007. Reduced cerebral ischemia-reperfusion injury in Toll-like receptor 4 deficient mice. Biochem Biophys Res Commun 353(2):509-14. PubMed: 17188246 MGI: J:117223
Carmona J; Cruz A; Moreira-Teixeira L; Sousa C; Sousa J; Osorio NS; Saraiva AL; Svenson S; Kallenius G; Pedrosa J; Rodrigues F; Castro AG; Saraiva M. 2013. Strains Are Differentially Recognized by TLRs with an Impact on the Immune Response. PLoS One 8(6):e67277. PubMed: 23840651 MGI: J:203717
Caso JR; Pradillo JM; Hurtado O; Lorenzo P; Moro MA; Lizasoain I. 2007. Toll-like receptor 4 is involved in brain damage and inflammation after experimental stroke. Circulation 115(12):1599-608. PubMed: 17372179 MGI: J:133065
Cenedeze MA; Goncalves GM; Feitoza CQ; Wang PM; Damiao MJ; Bertocchi AP; Pacheco-Silva A; Camara NO. 2007. The role of toll-like receptor 4 in cisplatin-induced renal injury. Transplant Proc 39(2):409-11. PubMed: 17362743 MGI: J:124472
Chapes SK; Mosier DA; Wright AD; Hart ML. 2001. MHCII, Tlr4 and Nramp1 genes control host pulmonary resistance against the opportunistic bacterium Pasteurella pneumotropica. J Leukoc Biol 69(3):381-6. PubMed: 11261784 MGI: J:69552
Chassin C; Goujon JM; Darche S; du Merle L; Bens M; Cluzeaud F; Werts C; Ogier-Denis E; Le Bouguenec C; Buzoni-Gatel D; Vandewalle A. 2006. Renal collecting duct epithelial cells react to pyelonephritis-associated Escherichia coli by activating distinct TLR4-dependent and -independent inflammatory pathways. J Immunol 177(7):4773-84. PubMed: 16982918 MGI: J:139309
Chen L; Guo S; Ranzer MJ; DiPietro LA. 2013. Toll-like receptor 4 has an essential role in early skin wound healing. Erratum 2014 page 583 J Invest Dermatol 133(1):258-67. PubMed: 22951730 MGI: J:196482
Choi HG; Kim WS; Back YW; Kim H; Kwon KW; Kim JS; Shin SJ; Kim HJ. 2015. Mycobacterium tuberculosis RpfE promotes simultaneous Th1- and Th17-type T-cell immunity via TLR4-dependent maturation of dendritic cells. Eur J Immunol 45(7):1957-71. PubMed: 25907170 MGI: J:229769
Choi SH; Harkewicz R; Lee JH; Boullier A; Almazan F; Li AC; Witztum JL; Bae YS; Miller YI. 2009. Lipoprotein accumulation in macrophages via toll-like receptor-4-dependent fluid phase uptake. Circ Res 104(12):1355-63. PubMed: 19461045 MGI: J:164760
Chung YW; Choi JH; Oh TY; Eun CS; Han DS. 2008. Lactobacillus casei prevents the development of dextran sulphate sodium-induced colitis in Toll-like receptor 4 mutant mice. Clin Exp Immunol 151(1):182-9. PubMed: 18005362 MGI: J:130145
Church JS; Kigerl KA; Lerch JK; Popovich PG; McTigue DM. 2016. TLR4 Deficiency Impairs Oligodendrocyte Formation in the Injured Spinal Cord. J Neurosci 36(23):6352-64. PubMed: 27277810 MGI: J:234345
Cole BC; Mu HH; Pennock ND; Hasebe A; Chan FV; Washburn LR; Peltier MR. 2005. Isolation and partial purification of macrophage- and dendritic cell-activating components from Mycoplasma arthritidis: association with organism virulence and involvement with Toll-like receptor 2. Infect Immun 73(9):6039-47. PubMed: 16113324 MGI: J:100413
Constante M; Wang D; Raymond VA; Bilodeau M; Santos MM. 2007. Repression of repulsive guidance molecule C during inflammation is independent of Hfe and involves tumor necrosis factor-alpha. Am J Pathol 170(2):497-504. PubMed: 17255318 MGI: J:117889
Coutinho A; Moller G; Gronowicz E. 1975. Genetical control of B-cell responses. IV. Inheritance of the unresponsiveness to lipopolysaccharides. J Exp Med 142(1):253-8. PubMed: 1097575 MGI: J:5557
Cunningham PN; Wang Y; Guo R; He G; Quigg RJ. 2004. Role of Toll-like receptor 4 in endotoxin-induced acute renal failure. J Immunol 172(4):2629-35. PubMed: 14764737 MGI: J:88059
Curran CS; Demick KP; Mansfield JM. 2006. Lactoferrin activates macrophages via TLR4-dependent and -independent signaling pathways. Cell Immunol 242(1):23-30. PubMed: 17034774 MGI: J:116741
D'Avila H; Melo RC; Parreira GG; Werneck-Barroso E; Castro-Faria-Neto HC; Bozza PT. 2006. Mycobacterium bovis bacillus Calmette-Guerin induces TLR2-mediated formation of lipid bodies: intracellular domains for eicosanoid synthesis in vivo. J Immunol 176(5):3087-97. PubMed: 16493068 MGI: J:129415
Da Costa CU; Wantia N; Kirschning CJ; Busch DH; Rodriguez N; Wagner H; Miethke T. 2004. Heat shock protein 60 from Chlamydia pneumoniae elicits an unusual set of inflammatory responses via Toll-like receptor 2 and 4 in vivo. Eur J Immunol 34(10):2874. PubMed: 15368304 MGI: J:92331
Dabbagh K; Dahl ME; Stepick-Biek P; Lewis DB. 2002. Toll-like receptor 4 is required for optimal development of Th2 immune responses: role of dendritic cells. J Immunol 168(9):4524-30. PubMed: 11970998 MGI: J:113992
De Filippo K; Henderson RB; Laschinger M; Hogg N. 2008. Neutrophil Chemokines KC and Macrophage-Inflammatory Protein-2 Are Newly Synthesized by Tissue Macrophages Using Distinct TLR Signaling Pathways. J Immunol 180(6):4308-15. PubMed: 18322244 MGI: J:132950
De Nardo D; Labzin LI; Kono H; Seki R; Schmidt SV; Beyer M; Xu D; Zimmer S; Lahrmann C; Schildberg FA; Vogelhuber J; Kraut M; Ulas T; Kerksiek A; Krebs W; Bode N; Grebe A; Fitzgerald ML; Hernandez NJ; Williams BR; Knolle P; Kneilling M; Rocken M; Lutjohann D; Wright SD; Schultze JL; Latz E. 2014. High-density lipoprotein mediates anti-inflammatory reprogramming of macrophages via the transcriptional regulator ATF3. Nat Immunol 15(2):152-60. PubMed: 24317040 MGI: J:209298
Dear JW; Yasuda H; Hu X; Hieny S; Yuen PS; Hewitt SM; Sher A; Star RA. 2006. Sepsis-induced organ failure is mediated by different pathways in the kidney and liver: acute renal failure is dependent on MyD88 but not renal cell apoptosis. Kidney Int 69(5):832-6. PubMed: 16518342 MGI: J:136506
Delano MJ; Kelly-Scumpia KM; Thayer TC; Winfield RD; Scumpia PO; Cuenca AG; Harrington PB; O'Malley KA; Warner E; Gabrilovich S; Mathews CE; Laface D; Heyworth PG; Ramphal R; Strieter RM; Moldawer LL; Efron PA. 2011. Neutrophil mobilization from the bone marrow during polymicrobial sepsis is dependent on CXCL12 signaling. J Immunol 187(2):911-8. PubMed: 21690321 MGI: J:178027
Dillon LM; Hida A; Garcia S; Prolla TA; Moraes CT. 2012. Long-term bezafibrate treatment improves skin and spleen phenotypes of the mtDNA mutator mouse. PLoS One 7(9):e44335. PubMed: 22962610 MGI: J:191639
Dugan CM; Fullerton AM; Roth RA; Ganey PE. 2011. Natural killer cells mediate severe liver injury in a murine model of halothane hepatitis. Toxicol Sci 120(2):507-18. PubMed: 21245496 MGI: J:171014
Dumont F; Barrois R. 1976. Electrokinetic properties of splenic lymphocytes from the low-lipopolysaccharide responder C3H/Hej mice. Folia Biol (Praha) 12(3):145-50. PubMed: 1086804 MGI: J:5721
Ehl S; Bischoff R; Ostler T; Vallbracht S; Schulte-Monting J; Poltorak A; Freudenberg M. 2004. The role of Toll-like receptor 4 versus interleukin-12 in immunity to respiratory syncytial virus. Eur J Immunol 34(4):1146-53. PubMed: 15048726 MGI: J:88878
Eisenbarth SC; Zhadkevich A; Ranney P; Herrick CA; Bottomly K. 2004. IL-4-dependent Th2 collateral priming to inhaled antigens independent of Toll-like receptor 4 and myeloid differentiation factor 88. J Immunol 172(7):4527-34. PubMed: 15034070 MGI: J:88724
Fairweather D; Yusung S; Frisancho S; Barrett M; Gatewood S; Steele R; Rose NR. 2003. IL-12 Receptor beta1 and Toll-Like Receptor 4 Increase IL-1beta- and IL-18-Associated Myocarditis and Coxsackievirus Replication. J Immunol 170(9):4731-7. PubMed: 12707353 MGI: J:83020
Familtseva A; Chaturvedi P; Kalani A; Jeremic N; Metreveli N; Kunkel GH; Tyagi SC. 2016. Toll-like receptor 4 mutation suppresses hyperhomocysteinemia-induced hypertension. Am J Physiol Cell Physiol 311(4):C596-C606. PubMed: 27488663 MGI: J:236621
Fei M; Bhatia S; Oriss TB; Yarlagadda M; Khare A; Akira S; Saijo S; Iwakura Y; Fallert Junecko BA; Reinhart TA; Foreman O; Ray P; Kolls J; Ray A. 2011. TNF-{alpha} from inflammatory dendritic cells (DCs) regulates lung IL-17A/IL-5 levels and neutrophilia versus eosinophilia during persistent fungal infection. Proc Natl Acad Sci U S A 108(13):5360-5. PubMed: 21402950 MGI: J:171233
Frendeus B; Godaly G; Hang L; Karpman D; Svanborg C. 2001. Interleukin-8 receptor deficiency confers susceptibility to acute pyelonephritis. J Infect Dis 183 Suppl 1:S56-60. PubMed: 11171016 MGI: J:120023
Frink M; Hsieh YC; Thobe BM; Choudhry MA; Schwacha MG; Bland KI; Chaudry IH. 2007. TLR4 regulates Kupffer cell chemokine production, systemic inflammation and lung neutrophil infiltration following trauma-hemorrhage. Mol Immunol 44(10):2625-30. PubMed: 17239439 MGI: J:118691
Frisancho-Kiss S; Davis SE; Nyland JF; Frisancho JA; Cihakova D; Barrett MA; Rose NR; Fairweather D. 2007. Cutting edge: cross-regulation by TLR4 and T cell Ig mucin-3 determines sex differences in inflammatory heart disease. J Immunol 178(11):6710-4. PubMed: 17513715 MGI: J:147853
Frisard MI; McMillan RP; Marchand J; Wahlberg KA; Wu Y; Voelker KA; Heilbronn L; Haynie K; Muoio B; Li L; Hulver MW. 2010. Toll-like receptor 4 modulates skeletal muscle substrate metabolism. Am J Physiol Endocrinol Metab 298(5):E988-98. PubMed: 20179247 MGI: J:162884
Gangloff SC; Zahringer U; Blondin C; Guenounou M; Silver J; Goyert SM. 2005. Influence of CD14 on ligand interactions between lipopolysaccharide and its receptor complex. J Immunol 175(6):3940-5. PubMed: 16148141 MGI: J:116691
Ganta RR; Wilkerson MJ; Cheng C; Rokey AM; Chapes SK. 2002. Persistent Ehrlichia chaffeensis infection occurs in the absence of functional major histocompatibility complex class II genes. Infect Immun 70(1):380-8. PubMed: 11748204 MGI: J:74569
Gao C; Kozlowska A; Nechaev S; Li H; Zhang Q; Hossain DM; Kowolik CM; Chu P; Swiderski P; Diamond DJ; Pal SK; Raubitschek A; Kortylewski M. 2013. TLR9 signaling in the tumor microenvironment initiates cancer recurrence after radiotherapy. Cancer Res 73(24):7211-21. PubMed: 24154870 MGI: J:206520
Geisel J; Kahl F; Muller M; Wagner H; Kirschning CJ; Autenrieth IB; Frick JS. 2007. IL-6 and maturation govern TLR2 and TLR4 induced TLR agonist tolerance and cross-tolerance in dendritic cells. J Immunol 179(9):5811-8. PubMed: 17947654 MGI: J:153008
Geisel RE; Sakamoto K; Russell DG; Rhoades ER. 2005. In vivo activity of released cell wall lipids of Mycobacterium bovis bacillus Calmette-Guerin is due principally to trehalose mycolates. J Immunol 174(8):5007-15. PubMed: 15814731 MGI: J:98152
Georgel P; Jiang Z; Kunz S; Janssen E; Mols J; Hoebe K; Bahram S; Oldstone MB; Beutler B. 2007. Vesicular stomatitis virus glycoprotein G activates a specific antiviral Toll-like receptor 4-dependent pathway. Virology 362(2):304-13. PubMed: 17292937 MGI: J:124488
Giangreco A; Hoste E; Takai Y; Rosewell I; Watt FM. 2012. Epidermal Cadm1 expression promotes autoimmune alopecia via enhanced T cell adhesion and cytotoxicity. J Immunol 188(3):1514-22. PubMed: 22210910 MGI: J:180748
Glickstein LJ; Coburn JL. 2006. Short report: Association of macrophage inflammatory response and cell death after in vitro Borrelia burgdorferi infection with arthritis resistance. Am J Trop Med Hyg 75(5):964-7. PubMed: 17123997 MGI: J:135947
Goodridge HS; Marshall FA; Else KJ; Houston KM; Egan C; Al-Riyami L; Liew FY; Harnett W; Harnett MM. 2005. Immunomodulation via novel use of TLR4 by the filarial nematode phosphorylcholine-containing secreted product, ES-62. J Immunol 174(1):284-93. PubMed: 15611251 MGI: J:95856
Grobner S; Schulz S; Soldanova I; Gunst DS; Waibel M; Wesselborg S; Borgmann S; Autenrieth IB. 2007. Absence of Toll-like receptor 4 signaling results in delayed Yersinia enterocolitica YopP-induced cell death of dendritic cells. Infect Immun 75(1):512-7. PubMed: 17074859 MGI: J:116649
Guo S; Al-Sadi R; Said HM; Ma TY. 2013. Lipopolysaccharide Causes an Increase in Intestinal Tight Junction Permeability in Vitro and in Vivo by Inducing Enterocyte Membrane Expression and Localization of TLR-4 and CD14. Am J Pathol 182(2):375-87. PubMed: 23201091 MGI: J:192566
Ha H; Lee JH; Kim HN; Kwak HB; Kim HM; Lee SE; Rhee JH; Kim HH; Lee ZH. 2008. Stimulation by TLR5 modulates osteoclast differentiation through STAT1/IFN-beta. J Immunol 180(3):1382-9. PubMed: 18209032 MGI: J:131353
Ha T; Li Y; Hua F; Ma J; Gao X; Kelley J; Zhao A; Haddad GE; Williams DL; William Browder I; Kao RL; Li C. 2005. Reduced cardiac hypertrophy in toll-like receptor 4-deficient mice following pressure overload. Cardiovasc Res 68(2):224-34. PubMed: 15967420 MGI: J:106358
Han H; Xu W; Headley MB; Jessup HK; Lee KS; Omori M; Comeau MR; Marshak-Rothstein A; Ziegler SF. 2012. Thymic stromal lymphopoietin (TSLP)-mediated dermal inflammation aggravates experimental asthma. Mucosal Immunol 5(3):342-51. PubMed: 22354320 MGI: J:199558
Hannan TJ; Mysorekar IU; Hung CS; Isaacson-Schmid ML; Hultgren SJ. 2010. Early severe inflammatory responses to uropathogenic E. coli predispose to chronic and recurrent urinary tract infection. PLoS Pathog 6(8):. PubMed: 20811584 MGI: J:167926
Hara K; Iijima K; Elias MK; Seno S; Tojima I; Kobayashi T; Kephart GM; Kurabayashi M; Kita H. 2014. Airway uric acid is a sensor of inhaled protease allergens and initiates type 2 immune responses in respiratory mucosa. J Immunol 192(9):4032-42. PubMed: 24663677 MGI: J:209984
Hartwig C; Mazzega M; Constabel H; Krishnaswamy JK; Gessner JE; Braun A; Tschernig T; Behrens GM. 2010. Fcgamma receptor-mediated antigen uptake by lung DC contributes to allergic airway hyper-responsiveness and inflammation. Eur J Immunol 40(5):1284-95. PubMed: 20148421 MGI: J:160960
Hasegawa M; Osaka T; Tawaratsumida K; Yamazaki T; Tada H; Chen GY; Tsuneda S; Nunez G; Inohara N. 2010. Transitions in oral and intestinal microflora composition and innate immune receptor-dependent stimulation during mouse development. Infect Immun 78(2):639-50. PubMed: 19933833 MGI: J:157789
Hasegawa T; Matsuguchi T; Noda K; Tanaka K; Kumamoto S; Shoyama Y; Yoshikai Y. 2002. Toll-like receptor 2 is at least partly involved in the antitumor activity of glycoprotein from Chlorella vulgaris. Int Immunopharmacol 2(4):579-89. PubMed: 11962736 MGI: J:76114
Headley MB; Zhou B; Shih WX; Aye T; Comeau MR; Ziegler SF. 2009. TSLP conditions the lung immune environment for the generation of pathogenic innate and antigen-specific adaptive immune responses. J Immunol 182(3):1641-7. PubMed: 19155513 MGI: J:144318
Herter S; Osterloh P; Hilf N; Rechtsteiner G; Hohfeld J; Rammensee HG; Schild H. 2005. Dendritic cell aggresome-like-induced structure formation and delayed antigen presentation coincide in influenza virus-infected dendritic cells. J Immunol 175(2):891-8. PubMed: 16002687 MGI: J:100719
Higgins SC; Lavelle EC; McCann C; Keogh B; McNeela E; Byrne P; O'Gorman B; Jarnicki A; McGuirk P; Mills KH. 2003. Toll-like receptor 4-mediated innate IL-10 activates antigen-specific regulatory T cells and confers resistance to Bordetella pertussis by inhibiting inflammatory pathology. J Immunol 171(6):3119-27. PubMed: 12960338 MGI: J:85389
Hiratsuka S; Watanabe A; Sakurai Y; Akashi-Takamura S; Ishibashi S; Miyake K; Shibuya M; Akira S; Aburatani H; Maru Y. 2008. The S100A8-serum amyloid A3-TLR4 paracrine cascade establishes a pre-metastatic phase. Nat Cell Biol 10(11):1349-55. PubMed: 18820689 MGI: J:145634
Hogan MM; Yancey KB; Vogel SN. 1989. Role of C5a in the induction of tumoricidal activity in C3H/HeJ (Lpsd) and C3H/OuJ (Lpsn) macrophages. J Leukoc Biol 46(6):565-70. PubMed: 2509612 MGI: J:24638
Holland WL; Bikman BT; Wang LP; Yuguang G; Sargent KM; Bulchand S; Knotts TA; Shui G; Clegg DJ; Wenk MR; Pagliassotti MJ; Scherer PE; Summers SA. 2011. Lipid-induced insulin resistance mediated by the proinflammatory receptor TLR4 requires saturated fatty acid-induced ceramide biosynthesis in mice. J Clin Invest 121(5):1858-70. PubMed: 21490391 MGI: J:173952
Hollestelle SC; De Vries MR; Van Keulen JK; Schoneveld AH; Vink A; Strijder CF; Van Middelaar BJ; Pasterkamp G; Quax PH; De Kleijn DP. 2004. Toll-like receptor 4 is involved in outward arterial remodeling. Circulation 109(3):393-8. PubMed: 14699006 MGI: J:101995
Hollingsworth JW; Whitehead G; Berman KG; Tekippe EM; Gilmour MI; Larkin JE; Quackenbush J; Schwartz DA. 2007. Genetic basis of murine antibacterial defense to streptococcal lung infection. Immunogenetics 59(9):713-24. PubMed: 17701033 MGI: J:125210
Hopkins W; Gendron-Fitzpatrick A; McCarthy DO; Haine JE; Uehling DT. 1996. Lipopolysaccharide-responder and nonresponder C3H mouse strains are equally susceptible to an induced Escherichia coli urinary tract infection. Infect Immun 64(4):1369-72. PubMed: 8606102 MGI: J:33518
Hopkins WJ; Gendron-Fitzpatrick A; Balish E; Uehling DT. 1998. Time course and host responses to Escherichia coli urinary tract infection in genetically distinct mouse strains. Infect Immun 66(6):2798-802. PubMed: 9596750 MGI: J:48225
Hoshino K; Takeuchi O; Kawai T; Sanjo H; Ogawa T; Takeda Y; Takeda K; Akira S. 1999. Cutting edge: Toll-like receptor 4 (TLR4)-deficient mice are hyporesponsive to lipopolysaccharide: evidence for TLR4 as the Lps gene product. J Immunol 162(7):3749-52. PubMed: 10201887 MGI: J:53519
Hsieh YC; Frink M; Thobe BM; Hsu JT; Choudhry MA; Schwacha MG; Bland KI; Chaudry IH. 2007. 17beta-Estradiol downregulates Kupffer cell TLR4-dependent p38 MAPK pathway and normalizes inflammatory cytokine production following trauma-hemorrhage. Mol Immunol 44(9):2165-72. PubMed: 17182102 MGI: J:117916
Hua F; Ha T; Ma J; Li Y; Kelley J; Gao X; Browder IW; Kao RL; Williams DL; Li C. 2007. Protection against myocardial ischemia/reperfusion injury in TLR4-deficient mice is mediated through a phosphoinositide 3-kinase-dependent mechanism. J Immunol 178(11):7317-24. PubMed: 17513782 MGI: J:147828
Huang X; Du W; McClellan SA; Barrett RP; Hazlett LD. 2006. TLR4 is required for host resistance in Pseudomonas aeruginosa keratitis. Invest Ophthalmol Vis Sci 47(11):4910-6. PubMed: 17065506 MGI: J:123090
Hui W; Jinxiang Z; Heshui W; Zhuoya L; Qichang Z. 2009. Bone marrow and non-bone marrow TLR4 regulates hepatic ischemia/reperfusion injury. Biochem Biophys Res Commun 389(2):328-32. PubMed: 19723506 MGI: J:153516
Hutchens MA; Luker KE; Sonstein J; Nunez G; Curtis JL; Luker GD. 2008. Protective effect of Toll-like receptor 4 in pulmonary vaccinia infection. PLoS Pathog 4(9):e1000153. PubMed: 18802464 MGI: J:162716
Ignacio-Souza LM; Bombassaro B; Pascoal LB; Portovedo MA; Razolli DS; Coope A; Victorio SC; de Moura RF; Nascimento LF; Arruda AP; Anhe GF; Milanski M; Velloso LA. 2014. Defective regulation of the ubiquitin/proteasome system in the hypothalamus of obese male mice. Endocrinology 155(8):2831-44. PubMed: 24892821 MGI: J:214459
Imai Y; Kuba K; Neely GG; Yaghubian-Malhami R; Perkmann T; van Loo G; Ermolaeva M; Veldhuizen R; Leung YH; Wang H; Liu H; Sun Y; Pasparakis M; Kopf M; Mech C; Bavari S; Peiris JS; Slutsky AS; Akira S; Hultqvist M; Holmdahl R; Nicholls J; Jiang C; Binder CJ; Penninger JM. 2008. Identification of oxidative stress and Toll-like receptor 4 signaling as a key pathway of acute lung injury. Cell 133(2):235-49. PubMed: 18423196 MGI: J:145306
Ito Y; Kawamura I; Kohda C; Tsuchiya K; Nomura T; Mitsuyama M. 2005. Seeligeriolysin O, a protein toxin of Listeria seeligeri, stimulates macrophage cytokine production via Toll-like receptors in a profile different from that induced by other bacterial ligands. Int Immunol 17(12):1597-606. PubMed: 16291660 MGI: J:103653
Jang S; Uematsu S; Akira S; Salgame P. 2004. IL-6 and IL-10 induction from dendritic cells in response to Mycobacterium tuberculosis is predominantly dependent on TLR2-mediated recognition. J Immunol 173(5):3392-7. PubMed: 15322203 MGI: J:92712
Jeyaseelan S; Chu HW; Young SK; Freeman MW; Worthen GS. 2005. Distinct roles of pattern recognition receptors CD14 and Toll-like receptor 4 in acute lung injury. Infect Immun 73(3):1754-63. PubMed: 15731076 MGI: J:96680
Jilling T; Simon D; Lu J; Meng FJ; Li D; Schy R; Thomson RB; Soliman A; Arditi M; Caplan MS. 2006. The roles of bacteria and TLR4 in rat and murine models of necrotizing enterocolitis. J Immunol 177(5):3273-82. PubMed: 16920968 MGI: J:139539
Jin JJ; Kim HD; Maxwell JA; Li L; Fukuchi K. 2008. Toll-like receptor 4-dependent upregulation of cytokines in a transgenic mouse model of Alzheimer's disease. J Neuroinflammation 5:23. PubMed: 18510752 MGI: J:174833
John B; Crispe IN. 2005. TLR-4 regulates CD8+ T cell trapping in the liver. J Immunol 175(3):1643-50. PubMed: 16034104 MGI: J:107284
Johnson DR; O'Connor JC; Hartman ME; Tapping RI; Freund GG. 2007. Acute hypoxia activates the neuroimmune system, which diabetes exacerbates. J Neurosci 27(5):1161-6. PubMed: 17267571 MGI: J:117904
Johnson GB; Riggs BL; Platt JL. 2004. A genetic basis for the 'Adonis' phenotype of low adiposity and strong bones. FASEB J 18(11):1282-4. PubMed: 15208271 MGI: J:118467
Jordan JM; Woods ME; Olano J; Walker DH. 2008. The absence of Toll-like receptor 4 signaling in C3H/HeJ mice predisposes them to overwhelming rickettsial infection and decreased protective Th1 responses. Infect Immun 76(8):3717-24. PubMed: 18490467 MGI: J:139397
Jude BA; Pobezinskaya Y; Bishop J; Parke S; Medzhitov RM; Chervonsky AV; Golovkina TV. 2003. Subversion of the innate immune system by a retrovirus. Nat Immunol 4(6):573-8. PubMed: 12730691 MGI: J:83088
Jung DY; Lee H; Jung BY; Ock J; Lee MS; Lee WH; Suk K. 2005. TLR4, but not TLR2, signals autoregulatory apoptosis of cultured microglia: a critical role of IFN-beta as a decision maker. J Immunol 174(10):6467-76. PubMed: 15879150 MGI: J:99051
Jung YW; Schoeb TR; Weaver CT; Chaplin DD. 2006. Antigen and lipopolysaccharide play synergistic roles in the effector phase of airway inflammation in mice. Am J Pathol 168(5):1425-34. PubMed: 16651610 MGI: J:108686
Juskewitch JE; Knudsen BE; Platt JL; Nath KA; Knutson KL; Brunn GJ; Grande JP. 2012. LPS-induced murine systemic inflammation is driven by parenchymal cell activation and exclusively predicted by early MCP-1 plasma levels. Am J Pathol 180(1):32-40. PubMed: 22067909 MGI: J:180166
Kallberg E; Vogl T; Liberg D; Olsson A; Bjork P; Wikstrom P; Bergh A; Roth J; Ivars F; Leanderson T. 2012. S100A9 interaction with TLR4 promotes tumor growth. PLoS One 7(3):e34207. PubMed: 22470535 MGI: J:187129
Kampfrath T; Maiseyeu A; Ying Z; Shah Z; Deiuliis JA; Xu X; Kherada N; Brook RD; Reddy KM; Padture NP; Parthasarathy S; Chen LC; Moffatt-Bruce S; Sun Q; Morawietz H; Rajagopalan S. 2011. Chronic fine particulate matter exposure induces systemic vascular dysfunction via NADPH oxidase and TLR4 pathways. Circ Res 108(6):716-26. PubMed: 21273555 MGI: J:183599
Kang S; Lee SP; Kim KE; Kim HZ; Memet S; Koh GY. 2009. Toll-like receptor 4 in lymphatic endothelial cells contributes to LPS-induced lymphangiogenesis by chemotactic recruitment of macrophages. Blood 113(11):2605-13. PubMed: 19098273 MGI: J:146303
Kang TH; Mao CP; Lee SY; Chen A; Lee JH; Kim TW; Alvarez RD; Roden RB; Pardoll D; Hung CF; Wu TC. 2013. Chemotherapy acts as an adjuvant to convert the tumor microenvironment into a highly permissive state for vaccination-induced antitumor immunity. Cancer Res 73(8):2493-504. PubMed: 23418322 MGI: J:196970
Karper JC; de Vries MR; van den Brand BT; Hoefer IE; Fischer JW; Jukema JW; Niessen HW; Quax PH. 2011. Toll-like receptor 4 is involved in human and mouse vein graft remodeling, and local gene silencing reduces vein graft disease in hypercholesterolemic APOE*3Leiden mice. Arterioscler Thromb Vasc Biol 31(5):1033-40. PubMed: 21330606 MGI: J:191490
Karst SY; Ward-Bailey PF; Donahue LR; Johnson KR; Davisson MT. 2007. Ruby eye 2-like (Ru2l): a new spontaneous mutation causing a light coat color and red eyes MGI Direct Data Submission :. MGI: J:123265
Katz J; Zhang P; Martin M; Vogel SN; Michalek SM. 2006. Toll-like receptor 2 is required for inflammatory responses to Francisella tularensis LVS. Infect Immun 74(5):2809-16. PubMed: 16622218 MGI: J:108092
Kayagaki N; Wong MT; Stowe IB; Ramani SR; Gonzalez LC; Akashi-Takamura S; Miyake K; Zhang J; Lee WP; Muszynski A; Forsberg LS; Carlson RW; Dixit VM. 2013. Noncanonical inflammasome activation by intracellular LPS independent of TLR4. Science 341(6151):1246-9. PubMed: 23887873 MGI: J:201075
Kerepesi LA; Leon O; Lustigman S; Abraham D. 2005. Protective immunity to the larval stages of onchocerca volvulus is dependent on Toll-like receptor 4. Infect Immun 73(12):8291-7. PubMed: 16299326 MGI: J:104303
Khan MA; Ma C; Knodler LA; Valdez Y; Rosenberger CM; Deng W; Finlay BB; Vallance BA. 2006. Toll-like receptor 4 contributes to colitis development but not to host defense during Citrobacter rodentium infection in mice. Infect Immun 74(5):2522-36. PubMed: 16622187 MGI: J:108095
Kigerl KA; Lai W; Rivest S; Hart RP; Satoskar AR; Popovich PG. 2007. Toll-like receptor (TLR)-2 and TLR-4 regulate inflammation, gliosis, and myelin sparing after spinal cord injury. J Neurochem 102(1):37-50. PubMed: 17403033 MGI: J:122597
Kilic U; Kilic E; Matter CM; Bassetti CL; Hermann DM. 2008. TLR-4 deficiency protects against focal cerebral ischemia and axotomy-induced neurodegeneration. Neurobiol Dis 31(1):33-40. PubMed: 18486483 MGI: J:138382
Kim HS; Han MS; Chung KW; Kim S; Kim E; Kim MJ; Jang E; Lee HA; Youn J; Akira S; Lee MS. 2007. Toll-like Receptor 2 Senses beta-Cell Death and Contributes to the Initiation of Autoimmune Diabetes. Immunity 27(2):321-33. PubMed: 17707128 MGI: J:124334
Kin NW; Sanders VM. 2006. CD86 stimulation on a B cell activates the phosphatidylinositol 3-kinase/Akt and phospholipase C gamma 2/protein kinase C alpha beta signaling pathways. J Immunol 176(11):6727-35. PubMed: 16709832 MGI: J:131798
Kirimanjeswara GS; Mann PB; Pilione M; Kennett MJ; Harvill ET. 2005. The complex mechanism of antibody-mediated clearance of Bordetella from the lungs requires TLR4. J Immunol 175(11):7504-11. PubMed: 16301658 MGI: J:122156
Kleeberger SR; Reddy SP; Zhang LY; Cho HY; Jedlicka AE. 2001. Toll-like receptor 4 mediates ozone-induced murine lung hyperpermeability via inducible nitric oxide synthase. Am J Physiol Lung Cell Mol Physiol 280(2):L326-33. PubMed: 11159012 MGI: J:108671
Koedel U; Angele B; Rupprecht T; Wagner H; Roggenkamp A; Pfister HW; Kirschning CJ. 2003. Toll-like receptor 2 participates in mediation of immune response in experimental pneumococcal meningitis. J Immunol 170(1):438-44. PubMed: 12496429 MGI: J:127283
Koga T; Lim JH; Jono H; Ha UH; Xu H; Ishinaga H; Morino S; Xu X; Yan C; Kai H; Li JD. 2008. Tumor suppressor cylindromatosis acts as a negative regulator for Streptococcus pneumoniae-induced NFAT signaling. J Biol Chem 283(18):12546-54. PubMed: 18332137 MGI: J:136838
Kolli D; Bao X; Liu T; Hong C; Wang T; Garofalo RP; Casola A. 2011. Human metapneumovirus glycoprotein G inhibits TLR4-dependent signaling in monocyte-derived dendritic cells. J Immunol 187(1):47-54. PubMed: 21632720 MGI: J:176038
Komai-Koma M; Gilchrist DS; Xu D. 2009. Direct recognition of LPS by human but not murine CD8+ T cells via TLR4 complex. Eur J Immunol 39(6):1564-72. PubMed: 19405031 MGI: J:149561
Komura H; Miksa M; Wu R; Goyert SM; Wang P. 2009. Milk fat globule epidermal growth factor-factor VIII is down-regulated in sepsis via the lipopolysaccharide-CD14 pathway. J Immunol 182(1):581-7. PubMed: 19109191 MGI: J:142885
Kozak W; Wrotek S; Kozak A. 2006. Pyrogenicity of CpG-DNA in mice: role of interleukin-6, cyclooxygenases, and nuclear factor-kappaB. Am J Physiol Regul Integr Comp Physiol 290(4):R871-80. PubMed: 16293680 MGI: J:115760
Kupz A; Guarda G; Gebhardt T; Sander LE; Short KR; Diavatopoulos DA; Wijburg OL; Cao H; Waithman JC; Chen W; Fernandez-Ruiz D; Whitney PG; Heath WR; Curtiss R 3rd; Tschopp J; Strugnell RA; Bedoui S. 2012. NLRC4 inflammasomes in dendritic cells regulate noncognate effector function by memory CD8 T cells. Nat Immunol 13(2):162-9. PubMed: 22231517 MGI: J:181212
Laird MH; Rhee SH; Perkins DJ; Medvedev AE; Piao W; Fenton MJ; Vogel SN. 2009. TLR4/MyD88/PI3K interactions regulate TLR4 signaling. J Leukoc Biol 85(6):966-77. PubMed: 19289601 MGI: J:149619
Lange S; Delbro DS; Jennische E; Mattsby-Baltzer I. 1996. The role of the Lps gene in experimental ulcerative colitis in mice. APMIS 104(11):823-33. PubMed: 8982246 MGI: J:37271
Laskin DL; Chen L; Hankey PA; Laskin JD. 2010. Role of STK in mouse liver macrophage and endothelial cell responsiveness during acute endotoxemia. J Leukoc Biol 88(2):373-82. PubMed: 20453108 MGI: J:163944
Lee EK; Kang SM; Paik DJ; Kim JM; Youn J. 2005. Essential roles of Toll-like receptor-4 signaling in arthritis induced by type II collagen antibody and LPS. Int Immunol 17(3):325-33. PubMed: 15684036 MGI: J:96356
Lee JS; Frevert CW; Matute-Bello G; Wurfel MM; Wong VA; Lin SM; Ruzinski J; Mongovin S; Goodman RB; Martin TR. 2005. TLR-4 pathway mediates the inflammatory response but not bacterial elimination in E. coli pneumonia. Am J Physiol Lung Cell Mol Physiol 289(5):L731-8. PubMed: 16024722 MGI: J:115440
Lee K; Hwang S; Paik DJ; Kim WK; Kim JM; Youn J. 2012. Bacillus-derived poly-gamma-glutamic acid reciprocally regulates the differentiation of T helper 17 and regulatory T cells and attenuates experimental autoimmune encephalomyelitis. Clin Exp Immunol 170(1):66-76. PubMed: 22943202 MGI: J:188286
Lee SJ; Kang JH; Choi SY; Suk KT; Kim DJ; Kwon OS. 2013. PKCdelta as a regulator for TGFbeta1-induced alpha-SMA production in a murine nonalcoholic steatohepatitis model. PLoS One 8(2):e55979. PubMed: 23441159 MGI: J:199411
Lehnardt S; Henneke P; Lien E; Kasper DL; Volpe JJ; Bechmann I; Nitsch R; Weber JR; Golenbock DT; Vartanian T. 2006. A mechanism for neurodegeneration induced by group B streptococci through activation of the TLR2/MyD88 pathway in microglia. J Immunol 177(1):583-92. PubMed: 16785556 MGI: J:134437
Lehnardt S; Lachance C; Patrizi S; Lefebvre S; Follett PL; Jensen FE; Rosenberg PA; Volpe JJ; Vartanian T. 2002. The toll-like receptor TLR4 is necessary for lipopolysaccharide-induced oligodendrocyte injury in the CNS. J Neurosci 22(7):2478-86. PubMed: 11923412 MGI: J:109244
Leite-de-Moraes MC; Herbelin A; Gombert JM; Vicari A; Papiernik M ; Dy M. 1997. Requirement of IL-7 for IL-4-producing potential of MHC class I-selected CD4-CD8-TCR alpha beta+ thymocytes. Int Immunol 9(1):73-9. PubMed: 9043949 MGI: J:40708
Leng CH; Chen HW; Chang LS; Liu HH; Liu HY; Sher YP; Chang YW; Lien SP; Huang TY; Chen MY; Chou AH; Chong P; Liu SJ. 2010. A recombinant lipoprotein containing an unsaturated fatty acid activates NF-kappaB through the TLR2 signaling pathway and induces a differential gene profile from a synthetic lipopeptide. Mol Immunol :. PubMed: 20478617 MGI: J:160689
Levy RM; Prince JM; Yang R; Mollen KP; Liao H; Watson GA; Fink MP; Vodovotz Y; Billiar TR. 2006. Systemic inflammation and remote organ damage following bilateral femur fracture requires Toll-like receptor 4. Am J Physiol Regul Integr Comp Physiol 291(4):R970-6. PubMed: 16675630 MGI: J:144408
Li H; Nookala S; Bina XR; Bina JE; Re F. 2006. Innate immune response to Francisella tularensis is mediated by TLR2 and caspase-1 activation. J Leukoc Biol 80(4):766-73. PubMed: 16895974 MGI: J:113031
Li Q; Cherayil BJ. 2004. Toll-like receptor 4 mutation impairs the macrophage TNFalpha response to peptidoglycan. Biochem Biophys Res Commun 325(1):91-6. PubMed: 15522205 MGI: J:93526
Liang CF; Liu JT; Wang Y; Xu A; Vanhoutte PM. 2013. Toll-like receptor 4 mutation protects obese mice against endothelial dysfunction by decreasing NADPH oxidase isoforms 1 and 4. Arterioscler Thromb Vasc Biol 33(4):777-84. PubMed: 23413427 MGI: J:217972
Liang Y; Ma S; Zhang Y; Wang Y; Cheng Q; Wu Y; Jin Y; Zheng D; Wu D; Liu H. 2014. IL-1beta and TLR4 signaling are involved in the aggravated murine acute graft-versus-host disease caused by delayed bortezomib administration. J Immunol 192(3):1277-85. PubMed: 24363427 MGI: J:207316
Liu H; Redline RW; Han YW. 2007. Fusobacterium nucleatum induces fetal death in mice via stimulation of TLR4-mediated placental inflammatory response. J Immunol 179(4):2501-8. PubMed: 17675512 MGI: J:151289
Liu S; Kielian T. 2009. Microglial activation by Citrobacter koseri is mediated by TLR4- and MyD88-dependent pathways. J Immunol 183(9):5537-47. PubMed: 19812209 MGI: J:156619
Liu Y; Yuan Y; Li Y; Zhang J; Xiao G; Vodovotz Y; Billiar TR; Wilson MA; Fan J. 2009. Interacting neuroendocrine and innate and acquired immune pathways regulate neutrophil mobilization from bone marrow following hemorrhagic shock. J Immunol 182(1):572-80. PubMed: 19109190 MGI: J:142886
Looney MR; Nguyen JX; Hu Y; Van Ziffle JA; Lowell CA; Matthay MA. 2009. Platelet depletion and aspirin treatment protect mice in a two-event model of transfusion-related acute lung injury. J Clin Invest 119(11):3450-61. PubMed: 19809160 MGI: J:154615
Loser K; Vogl T; Voskort M; Lueken A; Kupas V; Nacken W; Klenner L; Kuhn A; Foell D; Sorokin L; Luger TA; Roth J; Beissert S. 2010. The Toll-like receptor 4 ligands Mrp8 and Mrp14 are crucial in the development of autoreactive CD8+ T cells. Nat Med 16(6):713-7. PubMed: 20473308 MGI: J:161530
Loures FV; Pina A; Felonato M; Araujo EF; Leite KR; Calich VL. 2010. Toll-like receptor 4 signaling leads to severe fungal infection associated with enhanced proinflammatory immunity and impaired expansion of regulatory T cells. Infect Immun 78(3):1078-88. PubMed: 20008536 MGI: J:157774
Mahieu T; Park JM; Revets H; Pasche B; Lengeling A; Staelens J; Wullaert A; Vanlaere I; Hochepied T; van Roy F; Karin M; Libert C. 2006. The wild-derived inbred mouse strain SPRET/Ei is resistant to LPS and defective in IFN-beta production. Proc Natl Acad Sci U S A 103(7):2292-7. PubMed: 16455798 MGI: J:106066
Malley R; Henneke P; Morse SC; Cieslewicz MJ; Lipsitch M; Thompson CM; Kurt-Jones E; Paton JC; Wessels MR; Golenbock DT. 2003. Recognition of pneumolysin by Toll-like receptor 4 confers resistance to pneumococcal infection. Proc Natl Acad Sci U S A 100(4):1966-71. PubMed: 12569171 MGI: J:81975
Mann PB; Elder KD; Kennett MJ; Harvill ET. 2004. Toll-like receptor 4-dependent early elicited tumor necrosis factor alpha expression is critical for innate host defense against Bordetella bronchiseptica. Infect Immun 72(11):6650-8. PubMed: 15501798 MGI: J:93263
Mann PB; Kennett MJ; Harvill ET. 2004. Toll-like receptor 4 is critical to innate host defense in a murine model of bordetellosis. J Infect Dis 189(5):833-6. PubMed: 14976600 MGI: J:88587
Mann PB; Wolfe D; Latz E; Golenbock D; Preston A; Harvill ET. 2005. Comparative toll-like receptor 4-mediated innate host defense to Bordetella infection. Infect Immun 73(12):8144-52. PubMed: 16299309 MGI: J:104298
Maroso M; Balosso S; Ravizza T; Liu J; Aronica E; Iyer AM; Rossetti C; Molteni M; Casalgrandi M; Manfredi AA; Bianchi ME; Vezzani A. 2010. Toll-like receptor 4 and high-mobility group box-1 are involved in ictogenesis and can be targeted to reduce seizures. Nat Med 16(4):413-9. PubMed: 20348922 MGI: J:159308
Mattioli TA; Leduc-Pessah H; Skelhorne-Gross G; Nicol CJ; Milne B; Trang T; Cahill CM. 2014. Toll-like receptor 4 mutant and null mice retain morphine-induced tolerance, hyperalgesia, and physical dependence. PLoS One 9(5):e97361. PubMed: 24824631 MGI: J:216345
McCartney-Francis N; Jin W; Wahl SM. 2004. Aberrant Toll receptor expression and endotoxin hypersensitivity in mice lacking a functional TGF-beta 1 signaling pathway. J Immunol 172(6):3814-21. PubMed: 15004187 MGI: J:88604
Medoff BD; Wain JC; Seung E; Jackobek R; Means TK; Ginns LC; Farber JM; Luster AD. 2006. CXCR3 and its ligands in a murine model of obliterative bronchiolitis: regulation and function. J Immunol 176(11):7087-95. PubMed: 16709871 MGI: J:131767
Meng X; Ao L; Song Y; Raeburn CD; Fullerton DA; Harken AH. 2005. Signaling for myocardial depression in hemorrhagic shock: roles of Toll-like receptor 4 and p55 TNF-alpha receptor. Am J Physiol Regul Integr Comp Physiol 288(3):R600-6. PubMed: 15514106 MGI: J:96316
Milanski M; Arruda AP; Coope A; Ignacio-Souza LM; Nunez CE; Roman EA; Romanatto T; Pascoal LB; Caricilli AM; Torsoni MA; Prada PO; Saad MJ; Velloso LA. 2012. Inhibition of hypothalamic inflammation reverses diet-induced insulin resistance in the liver. Diabetes 61(6):1455-62. PubMed: 22522614 MGI: J:196822
Mishra PK; Wu W; Rozo C; Hallab NJ; Benevenia J; Gause WC. 2011. Micrometer-sized titanium particles can induce potent Th2-type responses through TLR4-independent pathways. J Immunol 187(12):6491-8. PubMed: 22095717 MGI: J:180376
Moayeri M; Martinez NW; Wiggins J; Young HA; Leppla SH. 2004. Mouse susceptibility to anthrax lethal toxin is influenced by genetic factors in addition to those controlling macrophage sensitivity. Infect Immun 72(8):4439-47. PubMed: 15271901 MGI: J:91775
Mollen KP; Levy RM; Prince JM; Hoffman RA; Scott MJ; Kaczorowski DJ; Vallabhaneni R; Vodovotz Y; Billiar TR. 2008. Systemic inflammation and end organ damage following trauma involves functional TLR4 signaling in both bone marrow-derived cells and parenchymal cells. J Leukoc Biol 83(1):80-8. PubMed: 17925504 MGI: J:130089
Monteiro AC; Schmitz V; Svensjo E; Gazzinelli RT; Almeida IC; Todorov A; de Arruda LB; Torrecilhas AC; Pesquero JB; Morrot A; Bouskela E; Bonomo A; Lima AP; Muller-Esterl W; Scharfstein J. 2006. Cooperative activation of TLR2 and bradykinin B2 receptor is required for induction of type 1 immunity in a mouse model of subcutaneous infection by Trypanosoma cruzi. J Immunol 177(9):6325-35. PubMed: 17056563 MGI: J:140513
Morari J; Anhe GF; Nascimento LF; de Moura RF; Razolli D; Solon C; Guadagnini D; Souza G; Mattos AH; Tobar N; Ramos CD; Pascoal VD; Saad MJ; Lopes-Cendes I; Moraes JC; Velloso LA. 2014. Fractalkine (CX3CL1) is involved in the early activation of hypothalamic inflammation in experimental obesity. Diabetes 63(11):3770-84. PubMed: 24947351 MGI: J:230177
Moreth K; Brodbeck R; Babelova A; Gretz N; Spieker T; Zeng-Brouwers J; Pfeilschifter J; Young MF; Schaefer RM; Schaefer L. 2010. The proteoglycan biglycan regulates expression of the B cell chemoattractant CXCL13 and aggravates murine lupus nephritis. J Clin Invest 120(12):4251-72. PubMed: 21084753 MGI: J:171866
Mortaz E; Redegeld FA; Nijkamp FP; Wong HR; Engels F. 2006. Acetylsalicylic acid-induced release of HSP70 from mast cells results in cell activation through TLR pathway. Exp Hematol 34(1):8-18. PubMed: 16413386 MGI: J:104576
Moses T; Wagner L; Fleming SD. 2009. TLR4-mediated Cox-2 expression increases intestinal ischemia/reperfusion-induced damage. J Leukoc Biol 86(4):971-80. PubMed: 19564573 MGI: J:153441
Mottillo EP; Shen XJ; Granneman JG. 2007. Role of hormone-sensitive lipase in beta-adrenergic remodeling of white adipose tissue. Am J Physiol Endocrinol Metab 293(5):E1188-97. PubMed: 17711991 MGI: J:126761
Mu HH; Sawitzke AD; Cole BC. 2001. Presence of Lps(d) mutation influences cytokine regulation in vivo by the Mycoplasma arthritidis mitogen superantigen and lethal toxicity in mice infected with M. arthritidis. Infect Immun 69(6):3837-44. PubMed: 11349049 MGI: J:69541
Mueller M; Postius S; Thimm JG; Gueinzius K; Muehldorfer I; Hermann C. 2004. Toll-like receptors 2 and 4 do not contribute to clearance of Chlamydophila pneumoniae in mice, but are necessary for the release of monokines. Immunobiology 209(8):599-608. PubMed: 15638128 MGI: J:101915
Naseemuddin M; Iqbal A; Nasti TH; Ghandhi JL; Kapadia AD; Yusuf N. 2012. Cell mediated immune responses through TLR4 prevents DMBA-induced mammary carcinogenesis in mice. Int J Cancer 130(4):765-74. PubMed: 21455984 MGI: J:181012
Neal MD; Leaphart C; Levy R; Prince J; Billiar TR; Watkins S; Li J; Cetin S; Ford H; Schreiber A; Hackam DJ. 2006. Enterocyte TLR4 mediates phagocytosis and translocation of bacteria across the intestinal barrier. J Immunol 176(5):3070-9. PubMed: 16493066 MGI: J:129416
Netea MG; Van Der Graaf CA; Vonk AG; Verschueren I; Van Der Meer JW; Kullberg BJ. 2002. The role of toll-like receptor (TLR) 2 and TLR4 in the host defense against disseminated candidiasis. J Infect Dis 185(10):1483-9. PubMed: 11992285 MGI: J:126008
Nishikubo K; Imanaka-Yoshida K; Tamaki S; Hiroe M; Yoshida T; Adachi Y; Yasutomi Y. 2007. Th1-type immune responses by Toll-like receptor 4 signaling are required for the development of myocarditis in mice with BCG-induced myocarditis. J Autoimmun 29(2-3):146-53. PubMed: 17698322 MGI: J:125182
Nolte MA; Leibundgut-Landmann S; Joffre O; Reis e Sousa C. 2007. Dendritic cell quiescence during systemic inflammation driven by LPS stimulation of radioresistant cells in vivo. J Exp Med 204(6):1487-501. PubMed: 17548522 MGI: J:125853
O'Brien AD; Weinstein DA; Soliman MY; Rosenstreich DL. 1985. Additional evidence that the Lps gene locus regulates natural resistance to S. typhimurium in mice. J Immunol 134(5):2820-3. PubMed: 3884708 MGI: J:7783
Ochoa-Cortes F; Ramos-Lomas T; Miranda-Morales M; Spreadbury I; Ibeakanma C; Barajas-Lopez C; Vanner S. 2010. Bacterial cell products signal to mouse colonic nociceptive dorsal root ganglia neurons. Am J Physiol Gastrointest Liver Physiol 299(3):G723-32. PubMed: 20576919 MGI: J:163333
Ogawa A; Tagawa T; Nishimura H; Yajima T; Abe T; Arai T; Taniguchi M; Takeda K; Akira S; Nimura Y; Yoshikai Y. 2006. Toll-like receptors 2 and 4 are differentially involved in Fas dependent apoptosis in Peyer's patch and the liver at an early stage after bile duct ligation in mice. Gut 55(1):105-13. PubMed: 16118350 MGI: J:135830
Oh GS; Kim HJ; Choi JH; Shen A; Kim CH; Kim SJ; Shin SR; Hong SH; Kim Y; Park C; Lee SJ; Akira S; Park R; So HS. 2011. Activation of lipopolysaccharide-TLR4 signaling accelerates the ototoxic potential of cisplatin in mice. J Immunol 186(2):1140-50. PubMed: 21148032 MGI: J:168789
Ohashi K; Burkart V; Flohe S; Kolb H. 2000. Cutting edge: heat shock protein 60 is a putative endogenous ligand of the toll-like receptor-4 complex. J Immunol 164(2):558-61. PubMed: 10623794 MGI: J:59296
Oliveira AC; Peixoto JR; de Arruda LB; Campos MA; Gazzinelli RT; Golenbock DT; Akira S; Previato JO; Mendonca-Previato L; Nobrega A; Bellio M. 2004. Expression of functional TLR4 confers proinflammatory responsiveness to Trypanosoma cruzi glycoinositolphospholipids and higher resistance to infection with T. cruzi. J Immunol 173(9):5688-96. PubMed: 15494520 MGI: J:93767
Oyama J; Blais C Jr; Liu X; Pu M; Kobzik L; Kelly RA; Bourcier T. 2004. Reduced myocardial ischemia-reperfusion injury in toll-like receptor 4-deficient mice. Circulation 109(6):784-9. PubMed: 14970116 MGI: J:102150
Pacheco P; Vieira-de-Abreu A; Gomes RN; Barbosa-Lima G; Wermelinger LB; Maya-Monteiro CM; Silva AR; Bozza MT; Castro-Faria-Neto HC; Bandeira-Melo C; Bozza PT. 2007. Monocyte chemoattractant protein-1/CC chemokine ligand 2 controls microtubule-driven biogenesis and leukotriene B4-synthesizing function of macrophage lipid bodies elicited by innate immune response. J Immunol 179(12):8500-8. PubMed: 18056397 MGI: J:155194
Palliser D; Huang Q; Hacohen N; Lamontagne SP; Guillen E; Young RA; Eisen HN. 2004. A role for Toll-like receptor 4 in dendritic cell activation and cytolytic CD8+ T cell differentiation in response to a recombinant heat shock fusion protein. J Immunol 172(5):2885-93. PubMed: 14978090 MGI: J:88229
Park JE; Kim YI; Yi AK. 2009. Protein kinase D1 is essential for MyD88-dependent TLR signaling pathway. J Immunol 182(10):6316-27. PubMed: 19414785 MGI: J:148236
Patnode ML; Bando JK; Krummel MF; Locksley RM; Rosen SD. 2014. Leukotriene B4 amplifies eosinophil accumulation in response to nematodes. J Exp Med 211(7):1281-8. PubMed: 24889202 MGI: J:214462
Patole PS; Schubert S; Hildinger K; Khandoga S; Khandoga A; Segerer S; Henger A; Kretzler M; Werner M; Krombach F; Schlondorff D; Anders HJ. 2005. Toll-like receptor-4: renal cells and bone marrow cells signal for neutrophil recruitment during pyelonephritis. Kidney Int 68(6):2582-7. PubMed: 16316333 MGI: J:116903
Peyssonnaux C; Zinkernagel AS; Datta V; Lauth X; Johnson RS; Nizet V. 2006. TLR4-dependent hepcidin expression by myeloid cells in response to bacterial pathogens. Blood 107(9):3727-32. PubMed: 16391018 MGI: J:132558
Pierer M; Wagner U; Rossol M; Ibrahim S. 2011. Toll-like receptor 4 is involved in inflammatory and joint destructive pathways in collagen-induced arthritis in DBA1J mice. PLoS One 6(8):e23539. PubMed: 21858160 MGI: J:176361
Poltorak A; He X; Smirnova I; Liu MY; Huffel CV; Du X; Birdwell D; Alejos E; Silva M; Galanos C; Freudenberg M; Ricciardi-Castagnoli P; Layton B; Beutler B. 1998. Defective LPS signaling in C3H/HeJ and C57BL/10ScCr mice: mutations in Tlr4 gene. Science 282(5396):2085-8. PubMed: 9851930 MGI: J:51522
Popovic ZV; Wang S; Papatriantafyllou M; Kaya Z; Porubsky S; Meisner M; Bonrouhi M; Burgdorf S; Young MF; Schaefer L; Grone HJ. 2011. The proteoglycan biglycan enhances antigen-specific T cell activation potentially via MyD88 and TRIF pathways and triggers autoimmune perimyocarditis. J Immunol 187(12):6217-26. PubMed: 22095710 MGI: J:180379
Prince LS; Okoh VO; Moninger TO; Matalon S. 2004. Lipopolysaccharide increases alveolar type II cell number in fetal mouse lungs through Toll-like receptor 4 and NF-kappaB. Am J Physiol Lung Cell Mol Physiol 287(5):L999-1006. PubMed: 15475494 MGI: J:98217
Qureshi ST; Gros P; Malo D. 1999. The Lps locus: genetic regulation of host responses to bacterial lipopolysaccharide Inflamm Res 48(12):613-20. PubMed: 10669111 MGI: J:60495
Qureshi ST; Lariviere L; Leveque G; Clermont S; Moore KJ; Gros P ; Malo D. 1999. Endotoxin-tolerant mice have mutations in Toll-like receptor 4 (Tlr4) [see comments] J Exp Med 189(4):615-25. PubMed: 9989976 MGI: J:53343
Rafi A; Nagarkatti M; Nagarkatti PS. 1997. Hyaluronate-CD44 interactions can induce murine B-cell activation. Blood 89(8):2901-8. PubMed: 9108410 MGI: J:39824
Rathinam VA; Appledorn DM; Hoag KA; Amalfitano A; Mansfield LS. 2009. Campylobacter jejuni-induced activation of dendritic cells involves cooperative signaling through Toll-like receptor 4 (TLR4)-MyD88 and TLR4-TRIF axes. Infect Immun 77(6):2499-507. PubMed: 19332531 MGI: J:149359
Redecha P; Tilley R; Tencati M; Salmon JE; Kirchhofer D; Mackman N; Girardi G. 2007. Tissue factor: a link between C5a and neutrophil activation in antiphospholipid antibody induced fetal injury. Blood 110(7):2423-31. PubMed: 17536017 MGI: J:147022
Reese TA; Liang HE; Tager AM; Luster AD; Van Rooijen N; Voehringer D; Locksley RM. 2007. Chitin induces accumulation in tissue of innate immune cells associated with allergy. Nature 447(7140):92-6. PubMed: 17450126 MGI: J:122735
Reiling N; Holscher C; Fehrenbach A; Kroger S; Kirschning CJ; Goyert S; Ehlers S. 2002. Cutting edge: Toll-like receptor (TLR)2- and TLR4-mediated pathogen recognition in resistance to airborne infection with Mycobacterium tuberculosis. J Immunol 169(7):3480-4. PubMed: 12244136 MGI: J:120386
Reino DC; Pisarenko V; Palange D; Doucet D; Bonitz RP; Lu Q; Colorado I; Sheth SU; Chandler B; Kannan KB; Ramanathan M; Xu da Z; Deitch EA; Feinman R. 2011. Trauma hemorrhagic shock-induced lung injury involves a gut-lymph-induced TLR4 pathway in mice. PLoS One 6(8):e14829. PubMed: 21829592 MGI: J:176529
Reynolds JM; Martinez GJ; Chung Y; Dong C. 2012. Toll-like receptor 4 signaling in T cells promotes autoimmune inflammation. Proc Natl Acad Sci U S A 109(32):13064-9. PubMed: 22826216 MGI: J:188488
Rico MA; Infantes S; Ramos M; Trento A; Johnstone C; Melero JA; Del Val M; Lopez D. 2010. TLR4-independent upregulation of activation markers in mouse B lymphocytes infected by HRSV. Mol Immunol 47(9):1802-7. PubMed: 20362337 MGI: J:160628
Riehl TE; Foster L; Stenson WF. 2012. Hyaluronic acid is radioprotective in the intestine through a TLR4 and COX-2-mediated mechanism. Am J Physiol Gastrointest Liver Physiol 302(3):G309-16. PubMed: 22038822 MGI: J:183323
Robays LJ; Lanckacker EA; Moerloose KB; Maes T; Bracke KR; Brusselle GG; Joos GF; Vermaelen KY. 2009. Concomitant inhalation of cigarette smoke and aerosolized protein activates airway dendritic cells and induces allergic airway inflammation in a TLR-independent way. J Immunol 183(4):2758-66. PubMed: 19635922 MGI: J:151472
Rocchi R; Kimura H; Tzou SC; Suzuki K; Rose NR; Pinchera A; Ladenson PW; Caturegli P. 2007. Toll-like receptor-MyD88 and Fc receptor pathways of mast cells mediate the thyroid dysfunctions observed during nonthyroidal illness. Proc Natl Acad Sci U S A 104(14):6019-24. PubMed: 17389381 MGI: J:120373
Rodriguez N; Lang R; Wantia N; Cirl C; Ertl T; Durr S; Wagner H; Miethke T. 2008. Induction of iNOS by Chlamydophila pneumoniae requires MyD88-dependent activation of JNK. J Leukoc Biol 84(6):1585-93. PubMed: 18799752 MGI: J:142747
Rodriguez N; Wantia N; Fend F; Durr S; Wagner H; Miethke T. 2006. Differential involvement of TLR2 and TLR4 in host survival during pulmonary infection with Chlamydia pneumoniae. Eur J Immunol 36(5):1145-55. PubMed: 16609927 MGI: J:114778
Roffe E; Rothfuchs AG; Santiago HC; Marino AP; Ribeiro-Gomes FL; Eckhaus M; Antonelli LR; Murphy PM. 2012. IL-10 limits parasite burden and protects against fatal myocarditis in a mouse model of Trypanosoma cruzi infection. J Immunol 188(2):649-60. PubMed: 22156594 MGI: J:180798
Romero CD; Varma TK; Hobbs JB; Reyes A; Driver B; Sherwood ER. 2011. The toll-like receptor 4 agonist monophosphoryl lipid a augments innate host resistance to systemic bacterial infection. Infect Immun 79(9):3576-87. PubMed: 21646453 MGI: J:175569
Ropelle ER; Flores MB; Cintra DE; Rocha GZ; Pauli JR; Morari J; de Souza CT; Moraes JC; Prada PO; Guadagnini D; Marin RM; Oliveira AG; Augusto TM; Carvalho HF; Velloso LA; Saad MJ; Carvalheira JB. 2010. IL-6 and IL-10 anti-inflammatory activity links exercise to hypothalamic insulin and leptin sensitivity through IKKbeta and ER stress inhibition. PLoS Biol 8(8):. PubMed: 20808781 MGI: J:166779
Rosenstein RK; Bezbradica JS; Yu S; Medzhitov R. 2014. Signaling pathways activated by a protease allergen in basophils. Proc Natl Acad Sci U S A 111(46):E4963-71. PubMed: 25369937 MGI: J:216741
Ruckdeschel K; Pfaffinger G; Haase R; Sing A; Weighardt H; Hacker G; Holzmann B; Heesemann J. 2004. Signaling of apoptosis through TLRs critically involves toll/IL-1 receptor domain-containing adapter inducing IFN-beta, but not MyD88, in bacteria-infected murine macrophages. J Immunol 173(5):3320-8. PubMed: 15322195 MGI: J:92674
Rudick CN; Jiang M; Yaggie RE; Pavlov VI; Done J; Heckman CJ; Whitfield C; Schaeffer AJ; Klumpp DJ. 2012. O-antigen modulates infection-induced pain states. PLoS One 7(8):e41273. PubMed: 22899994 MGI: J:189938
Rumbaut RE; Bellera RV; Randhawa JK; Shrimpton CN; Dasgupta SK; Dong JF; Burns AR. 2006. Endotoxin enhances microvascular thrombosis in mouse cremaster venules via a TLR4-dependent, neutrophil-independent mechanism. Am J Physiol Heart Circ Physiol 290(4):H1671-9. PubMed: 16284241 MGI: J:108441
Sanders CJ; Yu Y; Moore DA 3rd; Williams IR; Gewirtz AT. 2006. Humoral immune response to flagellin requires T cells and activation of innate immunity. J Immunol 177(5):2810-8. PubMed: 16920916 MGI: J:139555
Schaefer L; Babelova A; Kiss E; Hausser HJ; Baliova M; Krzyzankova M; Marsche G; Young MF; Mihalik D; Gotte M; Malle E; Schaefer RM; Grone HJ. 2005. The matrix component biglycan is proinflammatory and signals through Toll-like receptors 4 and 2 in macrophages. J Clin Invest 115(8):2223-2233. PubMed: 16025156 MGI: J:100228
Schilling JD; Mulvey MA; Vincent CD; Lorenz RG; Hultgren SJ. 2001. Bacterial invasion augments epithelial cytokine responses to Escherichia coli through a lipopolysaccharide-dependent mechanism. J Immunol 166(2):1148-55. PubMed: 11145696 MGI: J:66850
Schurr JR; Young E; Byrne P; Steele C; Shellito JE; Kolls JK. 2005. Central role of toll-like receptor 4 signaling and host defense in experimental pneumonia caused by Gram-negative bacteria. Infect Immun 73(1):532-45. PubMed: 15618193 MGI: J:94838
Scott MJ; Billiar TR. 2008. Beta2-integrin-induced p38 MAPK activation is a key mediator in the CD14/TLR4/MD2-dependent uptake of lipopolysaccharide by hepatocytes. J Biol Chem 283(43):29433-46. PubMed: 18701460 MGI: J:142561
Segreti J; Gheusi G; Dantzer R; Kelley KW; Johnson RW. 1997. Defect in interleukin-1beta secretion prevents sickness behavior in C3H/HeJ mice. Physiol Behav 61(6):873-8. PubMed: 9177560 MGI: J:41154
Sen G; Khan AQ; Chen Q; Snapper CM. 2005. In vivo humoral immune responses to isolated pneumococcal polysaccharides are dependent on the presence of associated TLR ligands. J Immunol 175(5):3084-91. PubMed: 16116197 MGI: J:113209
Shalaby KH; Allard-Coutu A; O'Sullivan MJ; Nakada E; Qureshi ST; Day BJ; Martin JG. 2013. Inhaled birch pollen extract induces airway hyperresponsiveness via oxidative stress but independently of pollen-intrinsic NADPH oxidase activity, or the TLR4-TRIF pathway. J Immunol 191(2):922-33. PubMed: 23776177 MGI: J:205448
Shalaby KH; Jo T; Nakada E; Allard-Coutu A; Tsuchiya K; Hirota N; Qureshi ST; Maghni K; Rioux CR; Martin JG. 2012. ICOS-expressing CD4 T cells induced via TLR4 in the nasal mucosa are capable of inhibiting experimental allergic asthma. J Immunol 189(6):2793-804. PubMed: 22908333 MGI: J:190232
Shen XD; Ke B; Zhai Y; Gao F; Busuttil RW; Cheng G; Kupiec-Weglinski JW. 2005. Toll-like receptor and heme oxygenase-1 signaling in hepatic ischemia/reperfusion injury. Am J Transplant 5(8):1793-800. PubMed: 15996225 MGI: J:114368
Silver K; Ferry H; Crockford T; Cornall RJ. 2006. TLR4, TLR9 and MyD88 are not required for the positive selection of autoreactive B cells into the primary repertoire. Eur J Immunol 36(6):1404-12. PubMed: 16703567 MGI: J:115059
Silvia OJ; Urosevic N. 1999. Variations in LPS responsiveness among different mouse substrains of C3H lineage and their congenic derivative sublines. Immunogenetics 50(5-6):354-7. PubMed: 10630301 MGI: J:169915
Sing A; Roggenkamp A; Geiger AM; Heesemann J. 2002. Yersinia enterocolitica evasion of the host innate immune response by V antigen-induced IL-10 production of macrophages is abrogated in IL-10-deficient mice. J Immunol 168(3):1315-21. PubMed: 11801671 MGI: J:127288
Skidmore BJ; Chiller JM; Weigle WO; Riblet R; Watson J. 1976. Immunologic properties of bacterial lipopolysaccharide (LPS). III. Genetic linkage between the in vitro mitogenic and in vivo adjuvant properties of LPS. J Exp Med 143(1):143-50. PubMed: 1244416 MGI: J:5593
Sodhi CP; Shi XH; Richardson WM; Grant ZS; Shapiro RA; Prindle T Jr; Branca M; Russo A; Gribar SC; Ma C; Hackam DJ. 2010. Toll-like receptor-4 inhibits enterocyte proliferation via impaired beta-catenin signaling in necrotizing enterocolitis. Gastroenterology 138(1):185-96. PubMed: 19786028 MGI: J:192520
Sokol CL; Barton GM; Farr AG; Medzhitov R. 2008. A mechanism for the initiation of allergen-induced T helper type 2 responses. Nat Immunol 9(3):310-8. PubMed: 18300366 MGI: J:131552
Sokol CL; Chu NQ; Yu S; Nish SA; Laufer TM; Medzhitov R. 2009. Basophils function as antigen-presenting cells for an allergen-induced T helper type 2 response. Nat Immunol 10(7):713-20. PubMed: 19465907 MGI: J:150141
Sorgi CA; Secatto A; Fontanari C; Turato WM; Belanger C; de Medeiros AI; Kashima S; Marleau S; Covas DT; Bozza PT; Faccioli LH. 2009. Histoplasma capsulatum cell wall {beta}-glucan induces lipid body formation through CD18, TLR2, and dectin-1 receptors: correlation with leukotriene B4 generation and role in HIV-1 infection. J Immunol 182(7):4025-35. PubMed: 19299700 MGI: J:147134
Souza AC; Tsuji T; Baranova IN; Bocharov AV; Wilkins KJ; Street JM; Alvarez-Prats A; Hu X; Eggerman T; Yuen PS; Star RA. 2015. TLR4 mutant mice are protected from renal fibrosis and chronic kidney disease progression. Physiol Rep 3(9):. PubMed: 26416975 MGI: J:229616
Spiller S; Dreher S; Meng G; Grabiec A; Thomas W; Hartung T; Pfeffer K; Hochrein H; Brade H; Bessler W; Wagner H; Kirschning CJ. 2007. Cellular recognition of trimyristoylated peptide or enterobacterial lipopolysaccharide via both TLR2 and TLR4. J Biol Chem 282(18):13190-8. PubMed: 17353199 MGI: J:121930
Spinner DS; Cho IS; Park SY; Kim JI; Meeker HC; Ye X; Lafauci G; Kerr DJ; Flory MJ; Kim BS; Kascsak RB; Wisniewski T; Levis WR; Schuller-Levis GB; Carp RI; Park E; Kascsak RJ. 2008. Accelerated prion disease pathogenesis in Toll-like receptor 4 signaling-mutant mice. J Virol 82(21):10701-8. PubMed: 18715916 MGI: J:142968
Standiford LR; Standiford TJ; Newstead MJ; Zeng X; Ballinger MN; Kovach MA; Reka AK; Bhan U. 2012. TLR4-dependent GM-CSF protects against lung injury in Gram-negative bacterial pneumonia. Am J Physiol Lung Cell Mol Physiol 302(5):L447-54. PubMed: 22160309 MGI: J:183448
Stark K; Philippi V; Stockhausen S; Busse J; Antonelli A; Miller M; Schubert I; Hoseinpour P; Chandraratne S; von Bruhl ML; Gaertner F; Lorenz M; Agresti A; Coletti R; Antoine DJ; Heermann R; Jung K; Reese S; Laitinen I; Schwaiger M; Walch A; Sperandio M; Nawroth PP; Reinhardt C; Jackel S; Bianchi ME; Massberg S. 2016. Disulfide HMGB1 derived from platelets coordinates venous thrombosis in mice. Blood 128(20):2435-2449. PubMed: 27574188 MGI: J:237387
Steiner AA; Chakravarty S; Rudaya AY; Herkenham M; Romanovsky AA. 2006. Bacterial lipopolysaccharide fever is initiated via Toll-like receptor 4 on hematopoietic cells. Blood 107(10):4000-2. PubMed: 16403908 MGI: J:132740
Stewart PW; Chapes SK. 2003. Role of major histocompatibility complex class II in resistance of mice to naturally acquired infection with Syphacia obvelata. Comp Med 53(1):70-4. PubMed: 12625509 MGI: J:82325
Suganami T; Mieda T; Itoh M; Shimoda Y; Kamei Y; Ogawa Y. 2007. Attenuation of obesity-induced adipose tissue inflammation in C3H/HeJ mice carrying a Toll-like receptor 4 mutation. Biochem Biophys Res Commun 354(1):45-9. PubMed: 17210129 MGI: J:117843
Suganami T; Yuan X; Shimoda Y; Uchio-Yamada K; Nakagawa N; Shirakawa I; Usami T; Tsukahara T; Nakayama K; Miyamoto Y; Yasuda K; Matsuda J; Kamei Y; Kitajima S; Ogawa Y. 2009. Activating transcription factor 3 constitutes a negative feedback mechanism that attenuates saturated Fatty acid/toll-like receptor 4 signaling and macrophage activation in obese adipose tissue. Circ Res 105(1):25-32. PubMed: 19478204 MGI: J:164755
Suhs KA; Marthaler BR; Welch RA; Hopkins WJ. 2011. Lack of association between the Tlr4 (Lpsd/Lpsd) genotype and increased susceptibility to Escherichia coli bladder infections in female C3H/HeJ mice. MBio 2(3):e00094-11. PubMed: 21628500 MGI: J:182202
Sun Y; Karmakar M; Roy S; Ramadan RT; Williams SR; Howell S; Shive CL; Han Y; Stopford CM; Rietsch A; Pearlman E. 2010. TLR4 and TLR5 on corneal macrophages regulate Pseudomonas aeruginosa keratitis by signaling through MyD88-dependent and -independent pathways. J Immunol 185(7):4272-83. PubMed: 20826748 MGI: J:164286
Suram S; Silveira LJ; Mahaffey S; Brown GD; Bonventre JV; Williams DL; Gow NA; Bratton DL; Murphy RC; Leslie CC. 2013. Cytosolic phospholipase A(2)alpha and eicosanoids regulate expression of genes in macrophages involved in host defense and inflammation. PLoS One 8(7):e69002. PubMed: 23950842 MGI: J:204931
Suzuki M; Nakano K. 1996. Increase in histamine synthesis by liver macrophages in CCl4-injured mast cell-deficient W/Wv mice. Biochem Pharmacol 52(5):809-13. PubMed: 8765479 MGI: J:35601
Tagliabue A; McCoy JL; Herberman RB. 1978. Refractoriness to migration inhibitory factor of macrophages of LPS nonresponder mouse strains. J Immunol 121(4):1223-6. PubMed: 359704 MGI: J:6043
Takakuwa T; Knopf HP; Sing A; Carsetti R; Galanos C; Freudenberg MA. 1996. Induction of CD14 expression in Lpsn, Lpsd and tumor necrosis factor receptor-deficient mice. Eur J Immunol 26(11):2686-92. PubMed: 8921956 MGI: J:36452
Tan AM; Chen HC; Pochard P; Eisenbarth SC; Herrick CA; Bottomly HK. 2010. TLR4 signaling in stromal cells is critical for the initiation of allergic Th2 responses to inhaled antigen. J Immunol 184(7):3535-44. PubMed: 20194715 MGI: J:160085
Tang SC; Arumugam TV; Xu X; Cheng A; Mughal MR; Jo DG; Lathia JD; Siler DA; Chigurupati S; Ouyang X; Magnus T; Camandola S; Mattson MP. 2007. Pivotal role for neuronal Toll-like receptors in ischemic brain injury and functional deficits. Proc Natl Acad Sci U S A 104(34):13798-803. PubMed: 17693552 MGI: J:124100
Tang SC; Lathia JD; Selvaraj PK; Jo DG; Mughal MR; Cheng A; Siler DA; Markesbery WR; Arumugam TV; Mattson MP. 2008. Toll-like receptor-4 mediates neuronal apoptosis induced by amyloid beta-peptide and the membrane lipid peroxidation product 4-hydroxynonenal. Exp Neurol 213(1):114-21. PubMed: 18586243 MGI: J:138608
Tanga FY; Nutile-McMenemy N; Deleo JA. 2005. The CNS role of Toll-like receptor 4 in innate neuroimmunity and painful neuropathy. Proc Natl Acad Sci U S A 102(16):5856-61. PubMed: 15809417 MGI: J:97819
Tavener SA; Long EM; Robbins SM; McRae KM; Van Remmen H; Kubes P. 2004. Immune cell Toll-like receptor 4 is required for cardiac myocyte impairment during endotoxemia. Circ Res 95(7):700-7. PubMed: 15358664 MGI: J:101491
Taylor KR; Yamasaki K; Radek KA; Di Nardo A; Goodarzi H; Golenbock D; Beutler B; Gallo RL. 2007. Recognition of hyaluronan released in sterile injury involves a unique receptor complex dependent on Toll-like receptor 4, CD44, and MD-2. J Biol Chem 282(25):18265-75. PubMed: 17400552 MGI: J:123387
Thaete LG; Qu XW; Jilling T; Crawford SE; Fitchev P; Hirsch E; Khan S; Neerhof MG. 2013. Impact of toll-like receptor 4 deficiency on the response to uterine ischemia/reperfusion in mice. Reproduction 145(5):517-26. PubMed: 23509372 MGI: J:197922
Thomas JA; Tsen MF; White DJ; Horton JW. 2002. TLR4 inactivation and rBPI(21) block burn-induced myocardial contractile dysfunction. Am J Physiol Heart Circ Physiol 283(4):H1645-55. PubMed: 12234819 MGI: J:108049
Timmers L; Sluijter JP; van Keulen JK; Hoefer IE; Nederhoff MG; Goumans MJ; Doevendans PA; van Echteld CJ; Joles JA; Quax PH; Piek JJ; Pasterkamp G; de Kleijn DP. 2008. Toll-like receptor 4 mediates maladaptive left ventricular remodeling and impairs cardiac function after myocardial infarction. Circ Res 102(2):257-64. PubMed: 18007026 MGI: J:145592
Tjota MY; Williams JW; Lu T; Clay BS; Byrd T; Hrusch CL; Decker DC; de Araujo CA; Bryce PJ; Sperling AI. 2013. IL-33-dependent induction of allergic lung inflammation by FcgammaRIII signaling. J Clin Invest 123(5):2287-97. PubMed: 23585480 MGI: J:201453
Treml LS; Carlesso G; Hoek KL; Stadanlick JE; Kambayashi T; Bram RJ; Cancro MP; Khan WN. 2007. TLR stimulation modifies BLyS receptor expression in follicular and marginal zone B cells. J Immunol 178(12):7531-9. PubMed: 17548587 MGI: J:148596
Tsukumo DM; Carvalho-Filho MA; Carvalheira JB; Prada PO; Hirabara SM; Schenka AA; Araujo EP; Vassallo J; Curi R; Velloso LA; Saad MJ. 2007. Loss-of-function mutation in Toll-like receptor 4 prevents diet-induced obesity and insulin resistance. Diabetes 56(8):1986-98. PubMed: 17519423 MGI: J:126488
Tsung A; Hoffman RA; Izuishi K; Critchlow ND; Nakao A; Chan MH; Lotze MT; Geller DA; Billiar TR. 2005. Hepatic ischemia/reperfusion injury involves functional TLR4 signaling in nonparenchymal cells. J Immunol 175(11):7661-8. PubMed: 16301676 MGI: J:122164
Tsung A; Klune JR; Zhang X; Jeyabalan G; Cao Z; Peng X; Stolz DB; Geller DA; Rosengart MR; Billiar TR. 2007. HMGB1 release induced by liver ischemia involves Toll-like receptor 4 dependent reactive oxygen species production and calcium-mediated signaling. J Exp Med 204(12):2913-23. PubMed: 17984303 MGI: J:128522
Tsung A; Sahai R; Tanaka H; Nakao A; Fink MP; Lotze MT; Yang H; Li J; Tracey KJ; Geller DA; Billiar TR. 2005. The nuclear factor HMGB1 mediates hepatic injury after murine liver ischemia-reperfusion. J Exp Med 201(7):1135-43. PubMed: 15795240 MGI: J:98036
Tsung A; Zheng N; Jeyabalan G; Izuishi K; Klune JR; Geller DA; Lotze MT; Lu L; Billiar TR. 2007. Increasing numbers of hepatic dendritic cells promote HMGB1-mediated ischemia-reperfusion injury. J Leukoc Biol 81(1):119-28. PubMed: 17062605 MGI: J:117230
Vazquez-Torres A; Vallance BA; Bergman MA; Finlay BB; Cookson BT; Jones-Carson J; Fang FC. 2004. Toll-like receptor 4 dependence of innate and adaptive immunity to Salmonella: importance of the Kupffer cell network. J Immunol 172(10):6202-8. PubMed: 15128808 MGI: J:89854
Velazquez P; Wei B; McPherson M; Mendoza LM; Nguyen SL; Turovskaya O; Kronenberg M; Huang TT; Schrage M; Lobato LN; Fujiwara D; Brewer S; Arditi M; Cheng G; Sartor RB; Newberry RD; Braun J. 2008. Villous B cells of the small intestine are specialized for invariant NK T cell dependence. J Immunol 180(7):4629-38. PubMed: 18354186 MGI: J:133099
Vogel SN; Johnson D; Perera PY; Medvedev A; Lariviere L; Qureshi ST ; Malo D. 1999. Cutting edge: functional characterization of the effect of the C3H/HeJ defect in mice that lack an Lpsn gene: in vivo evidence for a dominant negative mutation. J Immunol 162(10):5666-70. PubMed: 10229796 MGI: J:54987
Vogl T; Tenbrock K; Ludwig S; Leukert N; Ehrhardt C; van Zoelen MA; Nacken W; Foell D; van der Poll T; Sorg C; Roth J. 2007. Mrp8 and Mrp14 are endogenous activators of Toll-like receptor 4, promoting lethal, endotoxin-induced shock. Nat Med 13(9):1042-9. PubMed: 17767165 MGI: J:125179
Wang MJ; Jeng KC; Shih PC. 2000. Differential expression and regulation of macrophage inflammatory protein (MIP)-1alpha and MIP-2 genes by alveolar and peritoneal macrophages in LPS-hyporesponsive C3H/HeJ mice Cell Immunol 204(2):88-95. PubMed: 11069716 MGI: J:65822
Wang S; Schmaderer C; Kiss E; Schmidt C; Bonrouhi M; Porubsky S; Gretz N; Schaefer L; Kirschning CJ; Popovic ZV; Grone HJ. 2010. Recipient Toll-like receptors contribute to chronic graft dysfunction by both MyD88- and TRIF-dependent signaling. Dis Model Mech 3(1-2):92-103. PubMed: 20038715 MGI: J:157656
Wang X; Moser C; Louboutin JP; Lysenko ES; Weiner DJ; Weiser JN; Wilson JM. 2002. Toll-like receptor 4 mediates innate immune responses to Haemophilus influenzae infection in mouse lung. J Immunol 168(2):810-5. PubMed: 11777976 MGI: J:73739
Wang XM; Kim HP; Nakahira K; Ryter SW; Choi AM. 2009. The heme oxygenase-1/carbon monoxide pathway suppresses TLR4 signaling by regulating the interaction of TLR4 with caveolin-1. J Immunol 182(6):3809-18. PubMed: 19265160 MGI: J:145914
Wang Y; Han G; Wang K; Liu G; Wang R; Xiao H; Li X; Hou C; Shen B; Guo R; Li Y; Chen G. 2014. Tumor-derived GM-CSF promotes inflammatory colon carcinogenesis via stimulating epithelial release of VEGF. Cancer Res 74(3):716-26. PubMed: 24366884 MGI: J:208169
Wang ZY; Yang D; Chen Q; Leifer CA; Segal DM; Su SB; Caspi RR; Howard ZO; Oppenheim JJ. 2006. Induction of dendritic cell maturation by pertussis toxin and its B subunit differentially initiate Toll-like receptor 4-dependent signal transduction pathways. Exp Hematol 34(8):1115-24. PubMed: 16863919 MGI: J:111901
Wantia N; Rodriguez N; Cirl C; Ertl T; Durr S; Layland LE; Wagner H; Miethke T. 2011. Toll-like receptors 2 and 4 regulate the frequency of IFNgamma-producing CD4+ T-cells during pulmonary infection with Chlamydia pneumoniae. PLoS One 6(11):e26101. PubMed: 22096480 MGI: J:180980
Warger T; Hilf N; Rechtsteiner G; Haselmayer P; Carrick DM; Jonuleit H; von Landenberg P; Rammensee HG; Nicchitta CV; Radsak MP; Schild H. 2006. Interaction of TLR2 and TLR4 ligands with the N-terminal domain of Gp96 amplifies innate and adaptive immune responses. J Biol Chem 281(32):22545-53. PubMed: 16754684 MGI: J:116459
Watson J; Largen M; McAdam KP. 1978. Genetic control of endotoxic responses in mice. J Exp Med 147(1):39-49. PubMed: 342667 MGI: J:5938
Weighardt H; Kaiser-Moore S; Vabulas RM; Kirschning CJ; Wagner H; Holzmann B. 2002. Cutting edge: myeloid differentiation factor 88 deficiency improves resistance against sepsis caused by polymicrobial infection. J Immunol 169(6):2823-7. PubMed: 12218091 MGI: J:120435
Whitaker SM; Colmenares M; Pestana KG; McMahon-Pratt D. 2008. Leishmania pifanoi proteoglycolipid complex P8 induces macrophage cytokine production through Toll-like receptor 4. Infect Immun 76(5):2149-56. PubMed: 18299340 MGI: J:134478
Wong PM; Kang A; Chen H; Yuan Q; Fan P; Sultzer BM; Kan YW; Chung SW. 1999. Lps(d)/Ran of endotoxin-resistant C3H/HeJ mice is defective in mediating lipopolysaccharide endotoxin responses. Proc Natl Acad Sci U S A 96(20):11543-8. PubMed: 10500213 MGI: J:57938
Woods JP; Frelinger JA; Warrack G; Cannon JG. 1988. Mouse genetic locus Lps influences susceptibility to Neisseria meningitidis infection. Infect Immun 56(8):1950-5. PubMed: 3397181 MGI: J:27288
Wright SD; Burton C; Hernandez M; Hassing H; Montenegro J; Mundt S; Patel S; Card DJ; Hermanowski-Vosatka A; Bergstrom JD; Sparrow CP; Detmers PA; Chao YS. 2000. Infectious agents are not necessary for murine atherogenesis. J Exp Med 191(8):1437-42. PubMed: 10770809 MGI: J:61722
Wu SC; Yang JC; Rau CS; Chen YC; Lu TH; Lin MW; Tzeng SL; Wu YC; Wu CJ; Hsieh CH. 2013. Profiling circulating microRNA expression in experimental sepsis using cecal ligation and puncture. PLoS One 8(10):e77936. PubMed: 24205035 MGI: J:209241
Xiang M; Yin L; Li Y; Xiao G; Vodovotz Y; Billiar TR; Wilson MA; Fan J. 2011. Hemorrhagic shock activates lung endothelial reduced nicotinamide adenine dinucleotide phosphate (NADPH) oxidase via neutrophil NADPH oxidase. Am J Respir Cell Mol Biol 44(3):333-40. PubMed: 20418360 MGI: J:183358
Yan J; Zhang H; Yin Y; Li J; Tang Y; Purkayastha S; Li L; Cai D. 2014. Obesity- and aging-induced excess of central transforming growth factor-beta potentiates diabetic development via an RNA stress response. Nat Med 20(9):1001-8. PubMed: 25086906 MGI: J:227600
Yang HZ; Wang JP; Mi S; Liu HZ; Cui B; Yan HM; Yan J; Li Z; Liu H; Hua F; Lu W; Hu ZW. 2012. TLR4 activity is required in the resolution of pulmonary inflammation and fibrosis after acute and chronic lung injury. Am J Pathol 180(1):275-92. PubMed: 22062220 MGI: J:180182
Yang R; Murillo FM; Delannoy MJ; Blosser RL; Yutzy WH 4th; Uematsu S; Takeda K; Akira S; Viscidi RP; Roden RB. 2005. B lymphocyte activation by human papillomavirus-like particles directly induces Ig class switch recombination via TLR4-MyD88. J Immunol 174(12):7912-9. PubMed: 15944297 MGI: J:100870
Yang X; Murthy V; Schultz K; Tatro JB; Fitzgerald KA; Beasley D. 2006. Toll-like receptor 3 signaling evokes a proinflammatory and proliferative phenotype in human vascular smooth muscle cells. Am J Physiol Heart Circ Physiol 291(5):H2334-43. PubMed: 16782847 MGI: J:116310
Yano J; Palmer GE; Eberle KE; Peters BM; Vogl T; McKenzie AN; Fidel PL Jr. 2014. Vaginal epithelial cell-derived S100 alarmins induced by Candida albicans via pattern recognition receptor interactions are sufficient but not necessary for the acute neutrophil response during experimental vaginal candidiasis. Infect Immun 82(2):783-92. PubMed: 24478092 MGI: J:209808
Yao C; Purwanti N; Karabasil MR; Azlina A; Javkhlan P; Hasegawa T; Akamatsu T; Hosoi T; Ozawa K; Hosoi K. 2010. Potential down-regulation of salivary gland AQP5 by LPS via cross-coupling of NF-kappaB and p-c-Jun/c-Fos. Am J Pathol 177(2):724-34. PubMed: 20522648 MGI: J:163414
Yohe HC; O'Hara KA; Hunt JA; Kitzmiller TJ; Wood SG; Bement JL; Bement WJ; Szakacs JG; Wrighton SA; Jacobs JM; Kostrubsky V; Sinclair PR; Sinclair JF. 2006. Involvement of Toll-like receptor 4 in acetaminophen hepatotoxicity. Am J Physiol Gastrointest Liver Physiol 290(6):G1269-79. PubMed: 16439473 MGI: J:111091
Yoshida S; Goto Y; Miyamoto H; Fujio H; Mizuguchi Y. 1991. Association of Lps gene with natural resistance of mouse macrophages against Legionella pneumophila. FEMS Microbiol Immunol 4(1):51-6. PubMed: 1815711 MGI: J:657
Yu FS; Cornicelli MD; Kovach MA; Newstead MW; Zeng X; Kumar A; Gao N; Yoon SG; Gallo RL; Standiford TJ. 2010. Flagellin stimulates protective lung mucosal immunity: role of cathelicidin-related antimicrobial peptide. J Immunol 185(2):1142-9. PubMed: 20566829 MGI: J:162021
Yu H; Ha T; Liu L; Wang X; Gao M; Kelley J; Kao R; Williams D; Li C. 2012. Scavenger receptor A (SR-A) is required for LPS-induced TLR4 mediated NF-kappaB activation in macrophages. Biochim Biophys Acta 1823(7):1192-8. PubMed: 22627090 MGI: J:185204
Yusuf N; Nasti TH; Long JA; Naseemuddin M; Lucas AP; Xu H; Elmets CA. 2008. Protective role of Toll-like receptor 4 during the initiation stage of cutaneous chemical carcinogenesis. Cancer Res 68(2):615-22. PubMed: 18199559 MGI: J:131415
Yvan-Charvet L; Welch C; Pagler TA; Ranalletta M; Lamkanfi M; Han S; Ishibashi M; Li R; Wang N; Tall AR. 2008. Increased inflammatory gene expression in ABC transporter-deficient macrophages: free cholesterol accumulation, increased signaling via toll-like receptors, and neutrophil infiltration of atherosclerotic lesions. Circulation 118(18):1837-47. PubMed: 18852364 MGI: J:165622
Zamboni DS; Campos MA; Torrecilhas AC; Kiss K; Samuel JE; Golenbock DT; Lauw FN; Roy CR; Almeida IC; Gazzinelli RT. 2004. Stimulation of toll-like receptor 2 by Coxiella burnetii is required for macrophage production of pro-inflammatory cytokines and resistance to infection. J Biol Chem 279(52):54405-15. PubMed: 15485838 MGI: J:95155
Zampell JC; Elhadad S; Avraham T; Weitman E; Aschen S; Yan A; Mehrara BJ. 2012. Toll-like receptor deficiency worsens inflammation and lymphedema after lymphatic injury. Am J Physiol Cell Physiol 302(4):C709-19. PubMed: 22049214 MGI: J:180614
Zanotti G; Casiraghi M; Abano JB; Tatreau JR; Sevala M; Berlin H; Smyth S; Funkhouser WK; Burridge K; Randell SH; Egan TM. 2009. Novel critical role of Toll-like receptor 4 in lung ischemia-reperfusion injury and edema. Am J Physiol Lung Cell Mol Physiol 297(1):L52-63. PubMed: 19376887 MGI: J:151006
Zhai Y; Ao L; Cleveland JC; Zeng Q; Reece TB; Fullerton DA; Meng X. 2015. Toll-like receptor 4 mediates the inflammatory responses and matrix protein remodeling in remote non-ischemic myocardium in a mouse model of myocardial ischemia and reperfusion. PLoS One 10(3):e0121853. PubMed: 25823011 MGI: J:229566
Zhang B; Choi JJ; Eum SY; Daunert S; Toborek M. 2013. TLR4 signaling is involved in brain vascular toxicity of PCB153 bound to nanoparticles. PLoS One 8(5):e63159. PubMed: 23690990 MGI: J:202173
Zhang X; Shan P; Jiang G; Cohn L; Lee PJ. 2006. Toll-like receptor 4 deficiency causes pulmonary emphysema. J Clin Invest 116(11):3050-9. PubMed: 17053835 MGI: J:114985
Zhang Y; Woodruff M; Zhang Y; Miao J; Hanley G; Stuart C; Zeng X; Prabhakar S; Moorman J; Zhao B; Yin D. 2008. Toll-like receptor 4 mediates chronic restraint stress-induced immune suppression. J Neuroimmunol 194(1-2):115-22. PubMed: 18192029 MGI: J:131903
Zhou Q; Desta T; Fenton M; Graves DT; Amar S. 2005. Cytokine profiling of macrophages exposed to Porphyromonas gingivalis, its lipopolysaccharide, or its FimA protein. Infect Immun 73(2):935-43. PubMed: 15664935 MGI: J:95773
Zou L; Feng Y; Li Y; Zhang M; Chen C; Cai J; Gong Y; Wang L; Thurman JM; Wu X; Atkinson JP; Chao W. 2013. Complement factor B is the downstream effector of TLRs and plays an important role in a mouse model of severe sepsis. J Immunol 191(11):5625-35. PubMed: 24154627 MGI: J:207017
de Groot D; Hoefer IE; Grundmann S; Schoneveld A; Haverslag RT; van Keulen JK; Bot PT; Timmers L; Piek JJ; Pasterkamp G; de Kleijn DP. 2011. Arteriogenesis requires toll-like receptor 2 and 4 expression in bone-marrow derived cells. J Mol Cell Cardiol 50(1):25-32. PubMed: 20708624 MGI: J:171028
van Rossum AM; Lysenko ES; Weiser JN. 2005. Host and bacterial factors contributing to the clearance of colonization by Streptococcus pneumoniae in a murine model. Infect Immun 73(11):7718-26. PubMed: 16239576 MGI: J:104292

Also Known As: IL10T

Genetic overview

Marker(s)

Research Applications

Base Price

Important Note

Detailed Description

Development

Control Suggestions

Additional Information

Tlr4Lps-d

Allele Symbol: Tlr4Lps-d

Il10

Marker Symbol: Il10

Disease Terms

Research Areas By Genotype

This mouse can be used to support research in many areas including:

Genotype: Tlr4Lps-d related

References

Additional - Tlr4Lps-d related

Genotyping Protocols

Breeding Considerations

Appearance

Citation

Animal Health Reports

Production of mice from cryopreserved embryos or sperm occurs in a maximum barrier room, G200

Live Mouse

Cryorecovery - Pricing

Progeny testing is not required

Related Products and Services

Payment Terms and Conditions

The Jackson Laboratory's Genotype Promise

Terms of Use

Licensing Information

JAX® Mice, Products & Services Conditions of Use

No Warranty

Credit for PRODUCTS or SERVICES

Animal Care and Use for SERVICES

No Liability

Tlr4^Lps-d

Allele Symbol: Tlr4^Lps-d

Genotype: Tlr4^Lps-d related

Additional - Tlr4^Lps-d related