| Allele Name | transgene insertion 1, Beverly Paigen |
| Allele Type | Transgenic (Inserted expressed sequence) |
| Allele Synonym(s) | |
| Gene Symbol and Name | Tg(Mt1-Tnfsf4)1Pgn, transgene insertion 1, Beverly Paigen |
| Gene Synonym(s) | |
| Promoter | Mt1, metallothionein 1, mouse, laboratory |
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| Expressed Gene | Tnfsf4, tumor necrosis factor (ligand) superfamily, member 4, mouse, laboratory |
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| Strain of Origin | C57BL/6J |
| Chromosome | UN |
| General Note | This line is representative of four transgenic lines. According to the authors, although the line 2 was the primary one described in the reference, all four share the same phenotype. |
| Molecular Note | The Tnfsf4 cDNA, amplified from mRNA isolated from spleens of C57BL/6J mice, was placed under control of the ubiquitously expressed metallothionein promoter followed by the hemoglobin beta IVS intron. The 3' end of the cDNA, without its polyadenylation signal, was joined to a fragment of the human growth hormone gene, which distinguishes transgene-derived from endogenous transcripts. Transgenic mice express 4- to 250-fold higher levels, depending on tissue type, of transgenic mRNA than do nontransgenic littermates in liver, aorta, heart and spleen. |
