B6.129P2-Htr7^tm1Dgen/J

Stock number: 005769
Research areas: Metabolism Research, Neurobiology Research, Research Tools

Detailed description

This targeted mutant was created and characterized by Deltagen, Inc. View phenotypic data developed by Deltagen.

Development

The construct insert is reported to be "Lac0-SA-IRES-lacZ-Neo555G/Kan." Upon arrival at The Jackson Laboratory, these mice had been backcrossed at least 8 generations to C57BL/6 mice.

Allele

Symbol: Htr7^tm1Dgen
Name: targeted mutation 1, Deltagen
MGI accession ID: MGI:3604477
Generation method: Targeted
Attributes: Reporter; Null/Knockout
Marker symbol: Htr7
Marker name: 5-hydroxytryptamine (serotonin) receptor 7
Chromosome: 19
Strain of origin: 129P2/OlaHsd
Expressed genes: lacZ,beta-galactosidase,E. coli
Site of expression: lacZ expression is detected in the brain, spinal cord, skeletal muscle, testis and prostate gland.
Molecular note: A bacterial lacZ gene was inserted into the gene such that the endogenous gene promoter drives expression of beta-galactosidase. The highest levels of RNA transcripts are detectable in subcortical region, brainstem and spinal cord. Lower levels of RNA transcripts are also detectable in: whole brain, cortex, cerebellum, olfactory bulb, eye, Harderian glands, heart, lung, liver, pancreas, kidney, spleen, thymus, lymph nodes, skin, gallbladder, urinary bladder, pituitary gland, adrenal gland, salivary gland, skeletal muscle, tongue, stomach, small intestine, cecum, colon, testis, epididymis, seminal vesicle, coagulating gland, prostate gland, ovary, uterus and white fat. LacZ expression was detected in: brain, spinal cord, skeletal muscle, testis and prostate gland. LacZ expression was not detected in: sciatic nerve, eyes, thymus, spleen, lymph nodes, bone marrow, aorta, heart, lung, liver, pancreas, kidney, urinary bladder, thyroid gland, parathyroid gland, pituitary gland, adrenal glands, skin, mammary gland, ovary, uterus and cervix.