This targeted mutant was created and characterized by Deltagen, Inc. View phenotypic data developed by Deltagen.
Genetic Background | Generation |
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|
Allele Type | Gene Symbol | Gene Name |
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Targeted (Reporter, Null/Knockout) | Htr7 | 5-hydroxytryptamine (serotonin) receptor 7 |
This targeted mutant was created and characterized by Deltagen, Inc. View phenotypic data developed by Deltagen.
The construct insert is reported to be "Lac0-SA-IRES-lacZ-Neo555G/Kan." Upon arrival at The Jackson Laboratory, these mice had been backcrossed at least 8 generations to C57BL/6 mice.
Expressed Gene | lacZ, beta-galactosidase, E. coli |
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Site of Expression | lacZ expression is detected in the brain, spinal cord, skeletal muscle, testis and prostate gland. |
Allele Name | targeted mutation 1, Deltagen |
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Allele Type | Targeted (Reporter, Null/Knockout) |
Allele Synonym(s) | |
Gene Symbol and Name | Htr7, 5-hydroxytryptamine (serotonin) receptor 7 |
Gene Synonym(s) | |
Expressed Gene | lacZ, beta-galactosidase, E. coli |
Site of Expression | lacZ expression is detected in the brain, spinal cord, skeletal muscle, testis and prostate gland. |
Strain of Origin | 129P2/OlaHsd |
Chromosome | 19 |
Molecular Note | A bacterial lacZ gene was inserted into the gene such that the endogenous gene promoter drives expression of beta-galactosidase. The highest levels of RNA transcripts are detectable in subcortical region, brainstem and spinal cord. Lower levels of RNA transcripts are also detectable in: whole brain, cortex, cerebellum, olfactory bulb, eye, Harderian glands, heart, lung, liver, pancreas, kidney, spleen, thymus, lymph nodes, skin, gallbladder, urinary bladder, pituitary gland, adrenal gland, salivary gland, skeletal muscle, tongue, stomach, small intestine, cecum, colon, testis, epididymis, seminal vesicle, coagulating gland, prostate gland, ovary, uterus and white fat. LacZ expression was detected in: brain, spinal cord, skeletal muscle, testis and prostate gland.LacZ expression was not detected in: sciatic nerve, eyes, thymus, spleen, lymph nodes, bone marrow, aorta, heart, lung, liver, pancreas, kidney, urinary bladder, thyroid gland, parathyroid gland, pituitary gland, adrenal glands, skin, mammary gland, ovary, uterus and cervix. |
When using the B6.129P2-Htr7tm1Dgen/J mouse strain in a publication, please cite the originating article(s) and include JAX stock #005769 in your Materials and Methods section.
Facility Barrier Level Descriptions
Service/Product | Description | Price |
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Heterozygous or Wild-type for Htr7<tm1Dgen> |
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The Jackson Laboratory has rigorous genetic quality control and mutant gene genotyping programs to ensure the genetic background of JAX® Mice strains as well as the genotypes of strains with identified molecular mutations. JAX® Mice strains are only made available to researchers after meeting our standards. However, the phenotype of each strain may not be fully characterized and/or captured in the strain data sheets. Therefore, we cannot guarantee a strain's phenotype will meet all expectations. To ensure that JAX® Mice will meet the needs of individual research projects or when requesting a strain that is new to your research, we suggest ordering and performing tests on a small number of mice to determine suitability for your particular project. We do not guarantee breeding performance and therefore suggest that investigators order more than one breeding pair to avoid delays in their research.
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