These mice carry an ENU-induced mutation characterized by abnormal locomotion and body tremor.
The Jackson Laboratory cannot guarantee that cryorecovery of strains from the discontinued NIH-funded Neuroscience Mutagenesis Facility (NMF) will be successful or that the anticipated phenotype or genotype will be obtained. The cryorecovery fee for this effort will not be refunded or prorated if the recovery is unsuccessful or is in any way unsatisfactory. Genotyping will be the responsibility of the Purchaser.Read More +
These mutants are characterized by bi-directional circling behavior and body tremor. Occasionally they might pull head and shoulders together and move briskly backwards, while moving their head and shoulders from side to side. The onset of this phenotype is at approximately 5 weeks of age (average 4.7+/- 2.2 weeks; n=89). Standard pathology workup on two mutants (31 or 172 days of age) revealed no abnormalities. Whole ear exam of the older mutant showed no abnormalities, although otitis was noted in serial sections of the ears of the younger mutant. A colony can be maintained through regular breeding,although some females might have difficulties maintaining their pups.
This phenotypic deviant was generated by ethylnitrosourea (ENU) mutagenesis in C57BL/6J males (Stock No. 000664), in the Neuroscience Mutagenesis facility at The Jackson Laboratory. Mutagenized males were crossed to C57BL/6J females; G3 descendants of the mutagenized males were selected for neurological impairment.
|Allele Name||neuroscience mutagenesis facility, 370|
|Allele Type||Chemically induced (ENU)|
|Gene Symbol and Name||nmf370, neuroscience mutagenesis facility, 370|
|Strain of Origin||C57BL/6J|
|Molecular Note||This phenotypic mutation was identified in an ENU mutagenesis screen.|