These mice carry an ENU-induced mutation characterized by abnormal body movements and mild muscular dystrophy.
The Jackson Laboratory cannot guarantee that cryorecovery of strains from the discontinued NIH-funded Neuroscience Mutagenesis Facility (NMF) will be successful or that the anticipated phenotype or genotype will be obtained. The cryorecovery fee for this effort will not be refunded or prorated if the recovery is unsuccessful or is in any way unsatisfactory. Genotyping will be the responsibility of the Purchaser.Read More +
The mutants are smaller than their unaffected litter mates, show frequent spasms in front and hind limbs, shoulders, hind quarters, and/or their whole body, including occasional wet-dog-shake-like behavior; at times they also show splayed hind limbs. The on-set of this phenotype is at 6.8 weeks of age (+/- 1.5 weeks; n=81). Standard pathology work-up on four mutants (87 - 177days of age) revealed mild muscular dystrophy in only two of the mutants (94, 177 days of age). Otitis was noted in three of the four mutants (87, 134, 177 days of age). The colony can be maintained through regular breeding.
This phenotypic deviant was generated by ethylnitrosourea (ENU) mutagenesis in C57BL/6J males (Stock No. 000664), in the Neuroscience Mutagenesis facility at The Jackson Laboratory. Mutagenized males were crossed to C57BL/6J females; G3 descendants of the mutagenized males were selected for neurological impairment.
|Allele Name||neuroscience mutagenesis facility, 391|
|Allele Type||Chemically induced (ENU)|
|Gene Symbol and Name||nmf391, neuroscience mutagenesis facility, 391|
|Strain of Origin||C57BL/6J|
|Molecular Note||This phenotypic mutation was identified in an ENU mutagenesis screen.|