Homozygous wabbler-lethal mice are first recognizable at 12 days of age and usually die at about 4 weeks. They have an abnormal wobbly gait and a pronounced tremor when walking.
Genetic Background | Generation |
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|
Allele Type | Gene Symbol | Gene Name |
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Spontaneous | Atp8a2 | ATPase, aminophospholipid transporter-like, class I, type 8A, member 2 |
Homozygous wabbler-lethal mice are first recognizable at 12 days of age and usually die at about 4 weeks. They have an abnormal wobbly gait and a pronounced tremor when walking.
Allele Name | wabbler lethal |
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Allele Type | Spontaneous |
Allele Synonym(s) | Wl |
Gene Symbol and Name | Atp8a2, ATPase, aminophospholipid transporter-like, class I, type 8A, member 2 |
Gene Synonym(s) | |
Strain of Origin | STOCK Grxcr1pi |
Chromosome | 14 |
Molecular Note | Spontaneous deletion of 21 bp in exon 22 results in elimination of seven highly conserved amino acids (AIEDRLQ or IEDRLQA) from the nucleotide-binding domain (N-domain). |
When maintaining a live colony, heterozygous mice may be bred to C57BL/6J inbred mice (Stock No. 000664). Homozygotes usually die at about 4 weeks.
When using the wabbler lethal mouse strain in a publication, please cite the originating article(s) and include JAX stock #004835 in your Materials and Methods section.
Facility Barrier Level Descriptions
Service/Product | Description | Price |
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Heterozygous or wildtype for Atp8a2<wl> |
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The Jackson Laboratory has rigorous genetic quality control and mutant gene genotyping programs to ensure the genetic background of JAX® Mice strains as well as the genotypes of strains with identified molecular mutations. JAX® Mice strains are only made available to researchers after meeting our standards. However, the phenotype of each strain may not be fully characterized and/or captured in the strain data sheets. Therefore, we cannot guarantee a strain's phenotype will meet all expectations. To ensure that JAX® Mice will meet the needs of individual research projects or when requesting a strain that is new to your research, we suggest ordering and performing tests on a small number of mice to determine suitability for your particular project. We do not guarantee breeding performance and therefore suggest that investigators order more than one breeding pair to avoid delays in their research.
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