These Dab1 knock-out mice exhibit ataxia and have multiple defects in brain tissue.
Jonathan A. Cooper, Fred Hutchinson Cancer Research Center
Genetic Background | Generation |
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001026 BALB/cByJ |
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Allele Type | Gene Symbol | Gene Name |
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Targeted (Null/Knockout) | Dab1 | disabled 1 |
Homozygous Dab1-null mice become tremulous and ataxic at approximately postnatal day 10. Multiple defects can be detected in brain tissue. Lamellar structures in the cortex and hippocampus appear disorganized and the cerebellum is small and disorganized. Although homozygotes null reportedly die at 4-5 weeks on a mixed B6,129 or 129/Sv background, mice on a BALB/cByJ are viable. Homozygous females may breed but tend to be poor mothers.
Allele Name | targeted mutation 1, Jonathan A Cooper |
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Allele Type | Targeted (Null/Knockout) |
Allele Synonym(s) | Dab1-; Dab1 ko; mdab1-1 |
Gene Symbol and Name | Dab1, disabled 1 |
Gene Synonym(s) | |
Strain of Origin | 129S4/SvJaeSor |
Chromosome | 4 |
Molecular Note | A neomycin resistance cassette replaced a genomic fragment containing sequences encoding the first 47 amino acids of the PTB domain. Western blot analysis on brain lysates derived from homozygous mice demonstrated the absence of the protein. |
Mutations Made By | Jonathan Cooper, Fred Hutchinson Cancer Research Center |
When maintaining a live colony, heterozygous mice may be bred to wildtype siblings, or to BALB/cByJ inbred mice (Stock No. 001026). Homozygous females may breed but tend to be poor mothers. The expected coat color from breeding is albino.
When using the mdab1-1 mouse strain in a publication, please cite the originating article(s) and include JAX stock #003581 in your Materials and Methods section.
Facility Barrier Level Descriptions
Service/Product | Description | Price |
---|---|---|
Heterozygous or Wildtype for Dab1<tm1Cpr> |
Frozen Mouse Embryo | CBy.129S4-Dab1<tm1Cpr>/J | $2595.00 |
Frozen Mouse Embryo | CBy.129S4-Dab1<tm1Cpr>/J | $2595.00 |
Frozen Mouse Embryo | CBy.129S4-Dab1<tm1Cpr>/J | $3373.50 |
Frozen Mouse Embryo | CBy.129S4-Dab1<tm1Cpr>/J | $3373.50 |
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The Jackson Laboratory has rigorous genetic quality control and mutant gene genotyping programs to ensure the genetic background of JAX® Mice strains as well as the genotypes of strains with identified molecular mutations. JAX® Mice strains are only made available to researchers after meeting our standards. However, the phenotype of each strain may not be fully characterized and/or captured in the strain data sheets. Therefore, we cannot guarantee a strain's phenotype will meet all expectations. To ensure that JAX® Mice will meet the needs of individual research projects or when requesting a strain that is new to your research, we suggest ordering and performing tests on a small number of mice to determine suitability for your particular project. We do not guarantee breeding performance and therefore suggest that investigators order more than one breeding pair to avoid delays in their research.
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