C;129-Atf2^tm1Glm/J

Stock number: 002419
Product name: ATF-2-
Research areas: Neurobiology Research

Description

These Atf2^tm1Glm targeted mutant mice exhibit decreased postnatal viability and growth, with a defect in endochondral ossification at epiphyseal plates similar to human hypochondroplasia.

Detailed description

Mice homozygous for this mutation show decreased postnatal survival. Many of the mice die within the first 2 days of life or at the time of weaning. The growth of the surviving homozygous mice is impaired. Homozygous mice are hyperactive, display a very fine tremor, show an "exaggerated stretching of the hind limbs upon awakening", and have decreased grasping ability in the hind limbs. Homozygous mice have "increased numbers of microglia in the corpus callosum and other white matter tracts", as well as "larger, often distorted myelinated axons" in the spinal cord. Over half of homozygous mice develop a periocular inflammation consisting of neutrophils and lymphocytes.

Allele

Symbol: Atf2^tm1Glm
Name: targeted mutation 1, Laurie Glimcher
MGI accession ID: MGI:1857283
Generation method: Targeted
Attributes: Hypomorph
Marker symbol: Atf2
Marker name: activating transcription factor 2
Chromosome: 2
Strain of origin: 129S2/SvPas
Molecular note: A neomycin cassette was inserted into sequences corresponding to position 899 of the encoded mRNA (in the exon encoding amino acids 277-326). Although no full length protein is observed, these mice are hypomorphic as they express low levels of a novel spliced protein.