Mice homozygous for this mutation show decreased postnatal survival. Many of the mice die within the first 2 days of life or at the time of weaning. The growth of the surviving homozygous mice is impaired. Homozygous mice are hyperactive, display a very fine tremor, show an "exaggerated stretching of the hind limbs upon awakening", and have decreased grasping ability in the hind limbs. Homozygous mice have "increased numbers of microglia in the corpus callosum and other white matter tracts", as well as "larger, often distorted myelinated axons" in the spinal cord. Over half of homozygous mice develop a periocular inflammation consisting of neutrophils and lymphocytes.

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These Atf2tm1Glm targeted mutant mice exhibit decreased postnatal viability and growth, with a defect in endochondral ossification at epiphyseal plates similar to human hypochondroplasia.

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