129-Asgr2^tm1Her/J

Stock number: 002387
Product name: MHL-2 -
Research areas: Cancer Research, Cardiovascular Research, Metabolism Research

Description

These Asgr2 knock-out mice exhibit reduced expression of asialoglycoprotein receptor 1 (ASGR1).

Detailed description

Mice homozygous for the Asgr2^tm1Her targeted mutation are viable and have no obvious phenotype. There is no detectable ASGR2 expression and a pronounced reduction in ASGR1 expression. Expression of Asgr1 mRNA is not affected. Homozygous mutant mice are unable to clear ¹²⁵I labeled asialoorosmomucoid. Plasma desialylated glycoprotein levels are not increased. The plasma lipoprotein protein profile level of mice deficient in both LDLR and ASGR2 does not differ from the LDLR deficient strain arguing against a major role of ASGR in lipoprotein metabolism.

Allele

Symbol: Asgr2^tm1Her
Name: targeted mutation 1, Joachim Herz
MGI accession ID: MGI:1857130
Generation method: Targeted
Attributes: Null/Knockout
Marker symbol: Asgr2
Marker name: asialoglycoprotein receptor 2
Chromosome: 11
Strain of origin: 129S7/SvEvBrd-Hprt1⁺
Molecular note: A neomycin resistance cassette was inserted into exon 2. Northern blot analysis demonstrated that the transcript was not detectable in liver RNA from homozygous mice. The protein was also not detected in liver membrane protein fractions derived from homozygous mice.