This strain is currently unavailable due to replenishing of cryopreserved stocks -- Please have customer Register Interest.
These Asgr2 knock-out mice exhibit reduced expression of asialoglycoprotein receptor 1 (ASGR1).
Dr. Joachim Herz, Univ of Texas Southwest Med Ctr Dallas
Genetic Background | Generation |
---|---|
|
Allele Type | Gene Symbol | Gene Name |
---|---|---|
Targeted (Null/Knockout) | Asgr2 | asialoglycoprotein receptor 2 |
Mice homozygous for the Asgr2tm1Her targeted mutation are viable and have no obvious phenotype. There is no detectable ASGR2 expression and a pronounced reduction in ASGR1 expression. Expression of Asgr1 mRNA is not affected. Homozygous mutant mice are unable to clear 125I labeled asialoorosmomucoid. Plasma desialylated glycoprotein levels are not increased. The plasma lipoprotein protein profile level of mice deficient in both LDLR and ASGR2 does not differ from the LDLR deficient strain arguing against a major role of ASGR in lipoprotein metabolism.
Allele Name | targeted mutation 1, Joachim Herz |
---|---|
Allele Type | Targeted (Null/Knockout) |
Allele Synonym(s) | ASGP-R2-; HL-2 - |
Gene Symbol and Name | Asgr2, asialoglycoprotein receptor 2 |
Gene Synonym(s) | |
Strain of Origin | 129S7/SvEvBrd-Hprt+ |
Chromosome | 11 |
Molecular Note | A neomycin resistance cassette was inserted into exon 2. Northern blot analysis demonstrated that the transcript was not detectable in liver RNA from homozygous mice. The protein was also not detected in liver membrane protein fractions derived from homozygous mice. |
Mutations Made By | Dr. Joachim Herz, Univ of Texas Southwest Med Ctr Dallas |
This strain is maintained by homozygotes sibling matings.
When using the MHL-2 - mouse strain in a publication, please cite the originating article(s) and include JAX stock #002387 in your Materials and Methods section.
What information were you hoping to find through your search?
How easy was it to find what you were looking for?
We may wish to follow up with you. Enter your email if you are happy for us to connect and reachout to you with more questions.
Please Enter a Valid Email Address
Thank you for sharing your feedback! We are working on improving the JAX Mice search. Come back soon for exciting changes.