|Allele Type||Gene Symbol||Gene Name|
|Chemically induced (other)||In(10)17Rk||inversion, Chr 10, Roderick 17|
|Marker Symbol||Marker Name|
|Hmga2||high mobility group AT-hook 2|
|In(10)17Rk-p||inversion, Chr 10, Roderick 17, proximal|
|In(10)17Rk-d||inversion, Chr 10, Roderick 17, distal|
This triethylene melamine-induced inversion of approximately 60 cM has its proximal breakpoint in intron 2 of Txlnb and its distal breakpoint in intron 3 of Hmga2. A fusion transcript of Hmg2a exons 4 and 5 and Txlnb exons 1 and 2 was identified in embryonic day 12.5 samples. Homozygotes have a pygmy phenotype, initially designated pygmy Jackson, which was proven allelic by comlementation test with Hmg2apg. These homozygotes are small and sterile. Although heterozygotes have reduced levels of Tlxnb in heart and femur muscle and homozygotes lack wildtype Txlnb transcript, which is usually expressed specifically in muscle, a muscle phenotype has not been found.
DBA/2J males were treated with .3mg/kg body weight triethylene melamine and these treated males were bred with C57BL/6J females. In(10)17Rk was found in the offspring. This mutation was maintained by Tom Roderick and the KitlSl mutation was crossed into the stock as a repulsion marker for maintenance. Embryos were cryopreserved from C57BL/6J females bred with In(10)17Rk +/+ KitlSl repulsion males. Steel colored cryo-recovered pups will not have the inversion while non-steel pups will.
|Allele Name||inversion, Chr 10, Roderick 17|
|Allele Type||Chemically induced (other)|
|Allele Synonym(s)||Hmga2pg-J; In17Rk; pygmy Jackson|
|Gene Symbol and Name||In(10)17Rk, inversion, Chr 10, Roderick 17|
|Strain of Origin||DBA/2J|
|Molecular Note||This triethylene melamine-induced inversion of approximately 60 cM causes a homozygous pygmy phenotype, it is allelic by complementation test with Hmga2pg, the distal breakpoint is in intron 3 of Hmga2, and the proximal breakpoint is in intron 2 of Txlnb. A 3.7 kb fusion transcript of Hmga2 exons 4 and 5 and Txlnb exons 1 and 2 is produced. No other Txlnb transcript was found by northern blot of homozygous heart or femur.|
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