Heterozygotes are slightly smaller than normal and develop a sparse, graying, scruffy coat.  They have short ear pinnae, an underdeveloped lower jaw, malocclusion, protruding eyes, and low bone mineral density. The skulls are small and disproportionate, and the cranial sutures fail to close.  Females can have decreased fertility, but males do not.  Males have diminished total body fat.  Homozygotes die by approximately 10 days of age, have dysplastic, ulcerated skin and oral mucosae, and a more severe deficiency in skull growth and mineralization.

<i>Lmna<sup>Dhe</sup></i> is a semi-dominant spontaneous mutation that causes a sparse coat and small external ears in heterozygotes and lethality in homozygotes. Dhe mice should provide a useful model for investigations of the pathogenesis of laminopathies.

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