AXB23/PgnJ

Stock number: 001690
Research areas: Neurobiology Research, Research Tools

Description

The AXB and BXA set of RI strains are useful in the genetic analysis of complex diseases. The individual strains within the RI set also differ in their susceptibility to infectious diseases and in their responses to alcohol, stress, and endotoxin. AXB and BXA strains are derived from the C57BL/6J (Stock No. 000664) and A/J (Stock No. 000646) progenitor strains.

Detailed description

The AXB and BXA set of RI strains are useful in the genetic analysis of several complex diseases including cardiovascular disease, diabetes, cancer, cleft palate, and hydrocephalus. The individual strains within the RI set also differ in their susceptibility to infectious diseases and in their responses to alcohol, stress, and endotoxin.

The strain distribution pattern (SDP) for the AXB RI strains is available through the Mouse Genome Informatics

Contributed Data Sets and Gene Network.

Additional tools and information are presented through the Mouse Phenome Database

Specialized Strain Panel Query Form, and

Gene Network .

Development

The AXB and BXA recombinant inbred (RI) set of strains were originally generated and maintained at the University of California, San Diego, and have been imported into The Jackson Laboratory. There were originally 51 AXB and BXA strains derived from the C57BL/6J (Stock No. 000664) and A/J (Stock No. 000646) progenitor strains. Many of the original strains are either extinct or were discarded due to genetic contamination. Please refer to Sampson et al., 1998 for more information.

Allele

Symbol: Nrg3^ska
Name: scaramanga
MGI accession ID: MGI:1889610
Generation method: Spontaneous
Synonyms: ska
Marker symbol: Nrg3
Marker name: neuregulin 3
Marker synonyms: HRG3; pro-NRG3; RGD1559678; ska
Chromosome: 14
Strain of origin: A/J
Molecular note: This allele maps to an interval between the microsatellite markers D14Mit14 and D14Mit80 located at 10.0 cM and 13.5 cM. The mutation identified is a microsatellite repeat within intron 7 of the gene. This simple sequence repeat (SSR) was found to completely cosegregate with the ska phenotype.

Allele

Symbol: Wnt9b^clf1
Name: cleft lip 1
MGI accession ID: MGI:1856821
Generation method: Spontaneous
Marker symbol: Wnt9b
Marker name: wingless-type MMTV integration site family, member 9B
Marker synonyms: clf; clf1; WNT14B; WNT15
Chromosome: 11
Strain of origin: A/WySn
Molecular note: This mutation is a novel insertion of an IAP transposon 3' from the gene. In addition, a standard genetic test of allelism between clf1 and a Wnt9b targeted mutation demonstrated noncomplementation, showing clf1 is an allele of Wnt9b.
General note: Unequal duplicate epistasis - the normal allele at clf1 is a dominant suppressor of the recessive phenotype at clf2, and the normal allele at clf2 is a semidominant suppressor of the recessive phenotype at the clf1 locus.