C57BL/6JEi-Chr Y^CB/EiJ

Stock number: 001543
Product name: B6Ei-Chr Y^CB
Research areas: Developmental Biology Research, Reproductive Biology Research

Detailed description

This Y^CB Chromosome on the C57BL/6J background results in Y-linked sex reversal wherein XY^CB are frequently hermaphrodites. These hermaphrodites often do breed.

Development

Capanna et al. (Chromosoma, 1976 v58 p341) trapped feral mice in the town of Larino, in Campobasso Province, Italy and found that the resulting stock had a variety of Robertsonian translocations. The Y Chromosome from this CB stock was backcrossed onto the inbred C57BL/6JEi background resulting in this consomic strain. Thus, the autosomal translocations of the CB stock are not present in this consomic strain. Embryos were cryopreserved from matings of C57BL/6JEi females with consomic males at generation N20.

Allele

Symbol: Sry^CB
Name: sex-determining region of Chr Y- CB
MGI accession ID: MGI:3784808
Generation method: Spontaneous
Marker symbol: Sry
Marker name: sex determining region of Chr Y
Marker synonyms: SRXX1; SRXY1; Sry3B; SRYGENE; TDF; TDY
Chromosome: Y
Strain of origin: CBA/J