NZW mice have a normal lifespan but do develop anti-DNA antibodies, high serum levels of retroviral gp70 antigen, and nephritis later in life. F1 hybrids of NZB/BlNJ and NZW/LacJ (Stock No. 100008) are widely used as a model for autoimmune disease resembling human systemic lupus erythematosus.Read More +
NZW mice have a normal lifespan but develop anti-DNA antibodies, high serum levels of retroviral gp70 antigen, and nephritis later in life. Although NZW mice have a large CD4+ T cell population, the proportion of FOXP3+ T regulatory cells (Treg) in the lymph nodes and spleen, but not thymus, is significantly decreased in comparison to several commonly used inbred strains (C57BL/6, BALB/c, NOD/ShiLtJ, CBA/J). F1 hybrids of NZB/BlNJ and NZW/LacJ (Stock No. 100008) are widely used as a model for autoimmune disease resembling human systemic lupus erythematosus.
In 2019-2020, researchers at The Jackson Laboratory discovered this inbred strain contains the Trem2S148E allele - a naturally occurring variant at position 48351151-48351152 on Chr 17 (rs108080490 and rs107649577; Ensembl GRCm38.p6). This TC to GA transition results in a serine to glutamic acid substitution at amino acid 148 (S148E).
The New Zealand White inbred strain (NZW) was produced by WH Hall in 1952 by inbreeding an outbred mouse colony and selection for white coat color. Dr. SE Bernstein at The Jackson Laboratory obtained NZW mice from the Laboratory Animal Center, Carshalton, Surrey (Lac) in 1981 and were subsequently transferred to the production colony. The current generation of inbreeding of NZW/LacJ mice is F48+.
|Allele Name||pink-eyed dilution|
|Allele Synonym(s)||p; R262X|
|Gene Symbol and Name||Oca2, oculocutaneous albinism II|
|Strain of Origin||Asiatic fancy mice|
|General Note|| |
Oca2p is a very old mutation carried in many varieties of fancy mice (J:12958). It has been suggested that the original mutation occurred in Japanese wild mice, Mus musculus molossinus (J:19782).
|Molecular Note||A nonsense substitution was identified to account for the phenotype. It is a C-to-T substitution in exon 7 in the codon for the 262nd amino acid of the OCA2 protein (p.R262*).|
|Gene Symbol and Name||Bfsp2, beaded filament structural protein 2, phakinin|
|Strain of Origin||129X1/SvJ|
|Molecular Note||A deletion of ~6 kb within intron B was identified in the 129X1/SvJ background. The deleted region included 24 bp of the exon 2 splice acceptor site. RT-PCR analysis identified transcript in which exon 2 is skipped and exon 1 splices directly to exon 3. The aberrant splicing generates a frameshift and ultimately a premature stop codon at position 2 of exon 3. Neither normal protein nor truncated fragments were detected by Western blot analysis. This mutation has been detected in 129S1/SvImJ, 129S2/SvPas, 129S4/SvJae, 129P2/OlaHsd, FVB/N, NZB/BlNJ, and NZW/LacJ backgrounds but not in C3H or C57BL/6J backgrounds.|
|Gene Symbol and Name||Pctp, phosphatidylcholine transfer protein|
|Strain of Origin||NZO|
|Molecular Note||A G-to-A transition in exon 4 resulted in the arginine to histidine substitution at amino acid 120 (p.R120H) in NZO, NZB/BINJ and NZW/LacJ strains. This mutation renders the protein inactive.|
|Allele Name||mutation 1|
|Allele Type||Spontaneous (Not Applicable)|
|Gene Symbol and Name||Tyro3, TYRO3 protein tyrosine kinase 3|
|Strain of Origin||various|
|Molecular Note||A single C-to-T transition in the signal sequence causes an arginine to tryptophan substitution at amino acid 13 (p.R13W).|
|Allele Type||Not Applicable (Not Specified)|
|Gene Symbol and Name||Cox7a2l, cytochrome c oxidase subunit 7A2 like|
|Strain of Origin||multiple strains|
|General Note||Querying the sequences of the Sanger Mouse Genomes Project reveals that the short allele with its 6 bp deletion exists in C57BL/6J, C57BL/10J, C57BL/6NJ, C58/J, BALB/cJ, C3H/HeH, 129S5/SvEvBrd, NZW/LacZ, and SEA/GnJ, but the long allele lacking the deletion exists in 129S1/SvImJ, A/J, AKR/J, BTBR T+ Itpr3tf/J, BUB/BnJ, C3H/HeJ, C57BR/cdJ, C57L/J, CAST/EiJ, CBA/J, DBA/1J, DBA/2J, FVB/NJ, I/LnJ, KK/HiJ, LEWES/EiJ, LP/J, MOLF/EiJ, NOD/ShiLtJ, NZB/BlNJ, NZO/HlLtJ, PWK/PhJ, RF/J, SPRET/EiJ, ST/bJ, WSB/EiJ, ZALENDE/EiJ.|
|Molecular Note||This allele contains a 6 bp microdeletion causing the loss of two amino acids and truncating the protein to 111 amino acids instead of 113 amino acids. It is found in BALB/cAnCrl, BALB/cJ, C57BL/6Cr, C57BL/6JCrl, C57BL/6JOlaHsd, C57BL/6NCrl, C57BL/6NJcl, C57BL/6NHsd, C57BL/6NTac, C57BL/6NJ, B6(CG)-Tyr |
When using the NZW mouse strain in a publication, please include JAX stock #001058 in your Materials and Methods section.
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