Roderick (1983) described the meiotic characteristic of this paracentric inversion: there were only 11% bridges detected, they were very small and smooth with few fragments found, suggesting a small inversion.
This paracentric inversion was induced with 0.5 mg/kg TEM in a DBA/2J male, which was most likely bred to a C57BL/6J female and the F1 backcrossed to C57BL/6J (Roderick, 1983). The strain was maintained by intercrossing In(15)35Rk/+ heterozygotes and then test mating the offspring to In(15)18Rk homozygotes. Sterility in the male offspring of that cross proved the present of In(15)35Rk in the parent because In(15)35Rk/In(15)18Rk males are sterile. Embryos were generated for cryopreservation from an In(15)35Rk heterozygous male bred to a C57BL/6J female so the cryorecovered pups will either be heterozygous carriers or wild-type.
|Allele Name||inversion, Chr 15, Roderick 35|
|Allele Type||Chemically induced (other)|
|Gene Symbol and Name||In(15)35Rk, inversion, Chr 15, Roderick 35|
|Strain of Origin||DBA/2J|
|Molecular Note||This inversion was induced with triethylene melamine and the breakpoints are in 15C and 15F4.|