These mice carry a spontaneous mutation at the Oca2 locus characterized by a significant dilution of coat color with pink eyes.
Read More +Genetic Background | Generation |
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Allele Type | Gene Symbol | Gene Name |
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Spontaneous | Oca2 | oculocutaneous albinism II |
Oca2p-J/Oca2p-J mice exhibit significant dilution of coat color with pink eyes, a phenotype similar to that produced by Oca2p/Oca2p. The Oca2p-J mutation is a partial deletion of the gene that completely ablates Oca2p function (Oakey et al. 1996).
The Oca2p-J mutation occurred spontaneously in the C3H/HeJ strain at The Jackson Laboratory in 1974.
Allele Name | pink-eyed dilution Jackson |
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Allele Type | Spontaneous |
Allele Synonym(s) | pJ |
Gene Symbol and Name | Oca2, oculocutaneous albinism II |
Gene Synonym(s) | |
Strain of Origin | C3H/HeJ |
Chromosome | 7 |
Molecular Note | This allele was shown to be allelic to Oca2p by a complementation test. Southern blot analysis of Sst1-digested genomic DNA from mice homozygous for this allele, probed with a 1.0-kb DraIII fragment derived from cDNA clone MC2701, revealed deletion of two exon-bearing fragments (6.9 and 10.0 kb) found in wild-type DNA. The deletion has been shown to result in loss from the transcript of 350 base pairs encompassing nucleotides 2195-2545, derived from exons 20-23, and to produce a frameshift resulting in a protein additonally lacking exon 24-encoded amino acids. The missing amino acids include the last part of transmembrane domain 9 and all of transmembrane domains 10-12. |
When using the pink-eyed dilution Jackson mouse strain in a publication, please cite the originating article(s) and include JAX stock #000513 in your Materials and Methods section.
Facility Barrier Level Descriptions
Service/Product | Description | Price |
---|---|---|
Heterozygous for Oca2<p-J> |
Frozen Mouse Embryo | C3H/HeJ-Oca2<p-J>/J | $2595.00 |
Frozen Mouse Embryo | C3H/HeJ-Oca2<p-J>/J | $2595.00 |
Frozen Mouse Embryo | C3H/HeJ-Oca2<p-J>/J | $3373.50 |
Frozen Mouse Embryo | C3H/HeJ-Oca2<p-J>/J | $3373.50 |
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The Jackson Laboratory has rigorous genetic quality control and mutant gene genotyping programs to ensure the genetic background of JAX® Mice strains as well as the genotypes of strains with identified molecular mutations. JAX® Mice strains are only made available to researchers after meeting our standards. However, the phenotype of each strain may not be fully characterized and/or captured in the strain data sheets. Therefore, we cannot guarantee a strain's phenotype will meet all expectations. To ensure that JAX® Mice will meet the needs of individual research projects or when requesting a strain that is new to your research, we suggest ordering and performing tests on a small number of mice to determine suitability for your particular project. We do not guarantee breeding performance and therefore suggest that investigators order more than one breeding pair to avoid delays in their research.
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