AK.M-H2^m H2-T18^a/nSnJ

Stock number: 000470
Product name: AKR.M/nSn
Research areas: Immunology, Inflammation and Autoimmunity Research, Research Tools

Detailed description

This Snell “Congenic Resistant” strain carries the H2^m haplotype and the T region locus 18 allele ( H2-T18^a) from a non-inbred strain (M) carrying (a/a Tyrp1⁺/Tyrp1⁺/ Krt71^Ca/ Krt71^Ca).

Development

This strain was cryopreserved during 2001-03 at N12F85.

Allele

Symbol: Hc¹
Name: sufficient
MGI accession ID: MGI:3044820
Generation method: Not Applicable
Marker symbol: Hc
Marker name: hemolytic complement
Chromosome: 2
Strain of origin: multiple strains
Molecular note: This allele does not contain the 2 base "TA" deletion found in the Hc⁰ allele and is found in the following mouse strains BALB/cJ, C57BL/6J, DBA/1J, and B10.D2/nSnJ. This is equivalent to the wild-type allele.
General note:

Hc was identified as a candidate gene for Abhr2 in a microarray analysis of lung mRNA from A/J, C3H/HeJ, and (A/J x C3H/HeJ)F1 x A/J backcross animals. Hc genotype shows statistically significant correlation to allergen-induced bronchial hyperresponsive phenotype. The C3H/HeJ allele does not have the 2 bp deletion and is associated with resistance to allergen-induced bronchial hyperresponsiveness. (J:108211)

Allele

Symbol: H2^m
Name: histocompatibility-2, MHC; m variant
MGI accession ID: MGI:6323559
Generation method: Not Applicable
Attributes: Not Applicable
Marker symbol: H2
Marker name: histocompatibility-2, MHC
Chromosome: 17
Strain of origin: Not Specified
Molecular note: This histocomatibility haplotype is an H2-K^k H2-D^q recombinant between H2-K^k from AKR/J and H2-D^q from a non-inbred stock that Dr. George Snell referred to as M. The M stock also carried H2-T18^a.

Allele

Symbol: H2-T18^a
Name: a variant
MGI accession ID: MGI:4820507
Generation method: Not Applicable
Marker symbol: H2-T18
Marker name: histocompatibility 2, T region locus 18
Chromosome: 17
Strain of origin: Not Applicable
Molecular note: The allele H2-T18^a determines presence of the antigenic specificities TL.1, 2, 3, 5, 6, 7 and occurs in strains A, C57BR, C58, SJL, and others.

Allele

MGI accession ID: MGI:95950
Marker symbol: H2-T18
Marker name: histocompatibility 2, T region locus 18
Chromosome: 17

Allele

MGI accession ID: MGI:95894
Marker symbol: H2
Marker name: histocompatibility-2, MHC
Chromosome: 17