This Snell “Congenic Resistant” strain carries the H2m haplotype and the T region locus 18 allele ( H2-T18a) from a non-inbred strain (M) carrying (a/a Tyrp1+/Tyrp1+/ Krt71Ca/ Krt71Ca).
Genetic Background | Generation |
---|---|
000648 AKR/J |
|
Allele Type | Gene Symbol | Gene Name |
---|---|---|
Not Applicable | Hc | hemolytic complement |
Allele Type | Gene Symbol | Gene Name |
---|---|---|
Not Applicable | H2-T18 | histocompatibility 2, T region locus 18 |
Allele Type | Gene Symbol | Gene Name |
---|---|---|
Not Applicable (Not Applicable) | H2 | histocompatibility-2, MHC |
Marker Symbol | Marker Name | |
---|---|---|
H2 | histocompatibility-2, MHC | |
H2-T18 | histocompatibility 2, T region locus 18 |
This Snell “Congenic Resistant” strain carries the H2m haplotype and the T region locus 18 allele ( H2-T18a) from a non-inbred strain (M) carrying (a/a Tyrp1+/Tyrp1+/ Krt71Ca/ Krt71Ca).
This strain was cryopreserved during 2001-03 at N12F85.
Allele Name | sufficient |
---|---|
Allele Type | Not Applicable |
Allele Synonym(s) | C5 sufficient; C5-s; C5-suf |
Gene Symbol and Name | Hc, hemolytic complement |
Gene Synonym(s) | |
Strain of Origin | multiple strains |
Chromosome | 2 |
General Note | Hc was identified as a candidate gene for Abhr2 in a microarray analysis of lung mRNA from A/J, C3H/HeJ, and (A/J x C3H/HeJ)F1 x A/J backcross animals. Hc genotype shows statistically significant correlation to allergen-induced bronchial hyperresponsive phenotype. The C3H/HeJ allele does not have the 2 bp deletion and is associated with resistance to allergen-induced bronchial hyperresponsiveness. (J:108211) |
Molecular Note | This allele does not contain the 2 base "TA" deletion found in the Hc0 allele and is found in the following mouse strains BALB/cJ, C57BL/6J, DBA/1J, and B10.D2/nSnJ. This is equivalent to the wild-type allele. |
Allele Name | a variant |
---|---|
Allele Type | Not Applicable |
Allele Synonym(s) | Tlaa |
Gene Symbol and Name | H2-T18, histocompatibility 2, T region locus 18 |
Gene Synonym(s) | |
Strain of Origin | Not Applicable |
Chromosome | 17 |
Molecular Note | The allele H2-T18a determines presence of the antigenic specificities TL.1, 2, 3, 5, 6, 7 and occurs in strains A, C57BR, C58, SJL, and others. |
Allele Name | histocompatibility-2, MHC; m variant |
---|---|
Allele Type | Not Applicable (Not Applicable) |
Allele Synonym(s) | |
Gene Symbol and Name | H2, histocompatibility-2, MHC |
Gene Synonym(s) | |
Strain of Origin | Not Specified |
Chromosome | 17 |
Molecular Note | This histocomatibility haplotype is an H2-Kk H2-Dq recombinant between H2-Kk from AKR/J and H2-Dq from a non-inbred stock that Dr. George Snell referred to as M. The M stock also carried H2-T18a. |
Marker Synonym(s) | |
---|---|
Chromosome(s) | 17 |
Marker Synonym(s) | |
---|---|
Chromosome(s) | 17 |
When using the AKR.M/nSn mouse strain in a publication, please cite the originating article(s) and include JAX stock #000470 in your Materials and Methods section.
Facility Barrier Level Descriptions
Service/Product | Description | Price |
---|---|---|
Homozygous for H2<m>, Homozygous for H2-T18<a>, 1 pair minimum |
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The Jackson Laboratory has rigorous genetic quality control and mutant gene genotyping programs to ensure the genetic background of JAX® Mice strains as well as the genotypes of strains with identified molecular mutations. JAX® Mice strains are only made available to researchers after meeting our standards. However, the phenotype of each strain may not be fully characterized and/or captured in the strain data sheets. Therefore, we cannot guarantee a strain's phenotype will meet all expectations. To ensure that JAX® Mice will meet the needs of individual research projects or when requesting a strain that is new to your research, we suggest ordering and performing tests on a small number of mice to determine suitability for your particular project. We do not guarantee breeding performance and therefore suggest that investigators order more than one breeding pair to avoid delays in their research.
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