ATEB/LeJ

Stock number: 000277
Strain synonyms: Atrichosis Eye Blebs
Research areas: Dermatology Research, Developmental Biology Research, Internal/Organ Research, Reproductive Biology Research, Sensorineural Research

Description

This inbred segregating mutant strain carries the atrichosis (at) and eye blebs (Grip1^eb) spontaneous mutations in repulsion and is homozygous for dilute (Myo5a^d).

Detailed description

Mice homozygous for the atrichosis spontaneous mutation (at) are characterized by sparsely distributed hair, especially on the trunk. The amount of hair varies, but affected mice can be easily recognized at 8 to 10 days old. Both sexes are sterile and have very small gonads with few germ cells. There is a great deficiency of primary spermatogonia in the testes. A quantitative study of maturation of ovarian oocytes showed that the proportion of resident oocytes recruited into the first wave of growth was much higher than in phenotypically normal heterozygous controls (J.J. Eppig, personal communication). This strain is also segregating for the eye blebs spontaneous mutation (Grip1^eb).

Development

Embryos produced by sib matings of males heterozygous for at and Grip1^eb to females that were either heterozygous or wild-type for at and Grip1^eb were cryopreserved in 2006.

Allele

Symbol: Grip1^eb
Name: eye blebs
MGI accession ID: MGI:1856852
Generation method: Spontaneous
Marker symbol: Grip1
Marker name: glutamate receptor interacting protein 1
Chromosome: 10
Strain of origin: hairless stock
Molecular note: Deletion of exons 10 and 11.
General note:

Arose in a non-inbred stock of hairless mice. It resembles the mutant my, but is not allelic to it.

Allele

Symbol: at
Name: atrichosis
MGI accession ID: MGI:1856668
Generation method: Spontaneous
Marker symbol: at
Marker name: atrichosis
Chromosome: 10
Strain of origin: DBA/1oHu
General note: A quantitative study of maturation of oocytes in the ovary of homozygous at/at mice showed that the proportion of resident oocytes recruited into the first wave of growth was much higher than in normal heterozygous controls (JJ Eppig, personal communication).