This inbred segregating mutant strain carries the atrichosis (at) and eye blebs (Grip1eb) spontaneous mutations in repulsion and is homozygous for dilute (Myo5ad).Read More +
This strain is segregating for at and Grip1eb, which are maintained in repulsion. Mice homozygous for both at and Grip1eb do not survive.
Mice homozygous for the atrichosis spontaneous mutation (at) are characterized by sparsely distributed hair, especially on the trunk. The amount of hair varies, but affected mice can be easily recognized at 8 to 10 days old. Both sexes are sterile and have very small gonads with few germ cells. There is a great deficiency of primary spermatogonia in the testes. A quantitative study of maturation of ovarian oocytes showed that the proportion of resident oocytes recruited into the first wave of growth was much higher than in phenotypically normal heterozygous controls (J.J. Eppig, personal communication). This strain is also segregating for the eye blebs spontaneous mutation (Grip1eb).
Embryos produced by sib matings of males heterozygous for at and Grip1eb to females that were either heterozygous or wild-type for at and Grip1eb were cryopreserved in 2006.
|Gene Symbol and Name||at, atrichosis|
|Strain of Origin||DBA/1oHu|
|General Note||A quantitative study of maturation of oocytes in the ovary of homozygous at/at mice showed that the proportion of resident oocytes recruited into the first wave of growth was much higher than in normal heterozygous controls (JJ Eppig, personal communication).|
|Allele Name||eye blebs|
|Gene Symbol and Name||Grip1, glutamate receptor interacting protein 1|
|Strain of Origin||hairless stock|
|General Note|| |
Arose in a non-inbred stock of hairless mice. It resembles the mutant my, but is not allelic to it.
|Molecular Note||Deletion of exons 10 and 11.|
When using the ATEB/LeJ mouse strain in a publication, please include JAX stock #000277 in your Materials and Methods section.