This strain is homozygous for Tyrc-ch and segregating for Myo7ash1.
Mice homozygous for the shaker 1 spontaneous mutation (Myo7ash1) show circling, head-tossing, deafness, and hyperactivity characteristic of this type of mutant mice. Viability is normal, and breeding ability is high for a circling mutant. Homozygous mutant mice are most often deaf and swim well on the surface of water up to 4 weeks of age and more but lose the ability later. The degenerative changes of the labyrinth may occur a little later than in some of the other waltzing mutants. By light microscopy, the changes are seen to consist of degeneration of the organ of Corti, the spiral ganglion, and the stria vascularis in the cochlea, and of the saccular macula and the vestibular ganglion in the vestibular labyrinth.
The shaker 1 (Myo7ash1) strain originated in 1957 with two FS/Ei siblings at F5 mated. One sibling was also mated to a C57BL/6J and the offspring of the two FS/Ei mice were mated to a C3HeB/FeJ. Several within stock matings were made from both crosses and 2 siblings were each mated to a C3HeB/FeJ. Two generations were stock bred and the chinchilla shaker1 genotype was selected for inbreeding with the Myo7ash1 locus segregating. It was cryopreserved in 1989 by mating chinchilla shaker1 (Tyrc-ch Myo7ash1/Tyrc-ch Myo7ash1) males to chinchilla but shaker1 heterozygous (Tyrc-ch Myo7ash1/Tyrc-ch +) females at F96.
|Allele Name||shaker 1|
|Allele Synonym(s)||Myo7ash1; shaker 1|
|Gene Symbol and Name||Myo7a, myosin VIIA|
|Gene Synonym(s)||Myo7; MYU7A; NSRD2; polka; shaker 1; sh1; USH1B; neuroscience mutagenesis facility, 371; Hdb; sh-1; polka; headbanger; myosin VII; Hdb; Myo7; MYOVIIA; nmf371; nmf371; DFNA11; polka; DFNB2|
|Strain of Origin||BALB at F12|
|Molecular Note||A G-to-C transversion mutation is predicted to result in an arginine to proline change at position 502 in the encoded protein. This mutation is predicted to lie within the head domain of the protein. Northern blot analysis indicated that mRNA expression, size, and stability were unaffected. Immunoblot analysis showed that normal levels of the protein was expressed.|
|Allele Synonym(s)||chinchilla; Tyrc-ch|
|Gene Symbol and Name||Tyr, tyrosinase|
|Gene Synonym(s)||albino; ATN; c; CMM8; skin/coat color 35; OCA1; OCA1A; OCAIA; skc35; skc35; SHEP3; C; Oca1|
|Strain of Origin||fancier's stock|
|Molecular Note||The mutation in the chinchilla allele was found to be a G to A point mutation that results in an amino acid change at position 464 from alanine to threonine.|
When using the chinchilla shaker1 mouse strain in a publication, please include JAX stock #000271 in your Materials and Methods section.
|Homozygous for Tyr<c-ch>, Heterozygous or Homozygous for Myo7a<sh1>, 1 pair minimum|
We will fulfill your order by providing at least two carriers for each strain ordered. The total number, sex, and genotypes provided will vary, although typically 8 or more animals are provided. Please check genotypes which will be recovered. While the genotypes of all animals produced will be communicated to you prior to scheduling shipment, the genotypes of animals provided may not reflect the mating scheme and genotypes described in the strain description. Animals are typically ready to ship in 11-14 weeks. If a second recovery is required to produce the minimum number of animals, then delivery time would increase to approximately 25 weeks. If we fail to produce animals of the correct genotype, you will not be charged. We cannot guarantee the reproductive success of mice shipped to your facility. If the mice are lost after the first three days (post-arrival) or do not produce progeny at your facility, a new order and fee will be necessary.
Cryorecovery to establish a Dedicated Supply for greater quantities of mice. Mice recovered can be used to establish a dedicated colony to contractually supply you mice according to your requirements. Price by quotation.
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