This inbred mutant strain carries the the extreme nonagouti (ae) and white bellied agouti Jackson (Aw-J) coat color mutations along with the bradypneic (bd) spontaneous mutation.
Read More +Genetic Background | Generation |
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Allele Type | Gene Symbol | Gene Name |
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Radiation induced | a | nonagouti |
Allele Type | Gene Symbol | Gene Name |
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Spontaneous | a | nonagouti |
Allele Type | Gene Symbol | Gene Name |
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Spontaneous | bd | bradypneic |
This strain is segregating for recessive ae and dominant Aw-J.
Homozygous bd/bd mice show variable weight retardation beginning at 3 to 5 days. Severely affected mice die within the first two weeks; less severely affected mice may survive to weaning or to adulthood and may be fertile. Homozygotes tested at 3 weeks or older breathe at half the normal rate, but breathing is deeper and 02 consumption per unit of body surface is normal. Blood pH and blood C02 capacity are normal, and no obstruction has been found in the nasal passages, larynx, trachea, or bronchi. The lungs are somewhat emphysematous and the right atrium is enlarged. There is dilation of some of the distal tubules of the kidney, and large amounts of gas in the stomach and intestines. The cause of the breathing defect is not known, but the breathing defect may be responsible for the emphysema, intestinal gas, small size, and early death. (J:65322 Green MC, et al., bd - bradypneic. Mouse News Lett. 1977;56:40)
Bradypneic (bd) was found in December 1969 in the 21st generation of inbreeding of a strain segregating for Aw-J and ae/ae. Embryos produced by mating either Aw-J/ae bd/bd or ae/ae bd/bd males to AEJ/GnLeJ (Stock No. 000199) females were cryopreserved in 1983.
Allele Name | extreme nonagouti |
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Allele Type | Radiation induced |
Allele Synonym(s) | |
Gene Symbol and Name | a, nonagouti |
Gene Synonym(s) | |
Strain of Origin | (P x S)F1 |
Chromosome | 2 |
General Note | The ae mutation was found among descendants of an irradiated mouse. ae is recessive to all other alleles except al. |
When using the bradypneic mouse strain in a publication, please cite the originating article(s) and include JAX stock #000202 in your Materials and Methods section.
Facility Barrier Level Descriptions
Service/Product | Description | Price |
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Compound Heterozygous for allele A<w>and allele a<e> or Homozygous for a<e> and Heterozygous for +/bd |
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The Jackson Laboratory has rigorous genetic quality control and mutant gene genotyping programs to ensure the genetic background of JAX® Mice strains as well as the genotypes of strains with identified molecular mutations. JAX® Mice strains are only made available to researchers after meeting our standards. However, the phenotype of each strain may not be fully characterized and/or captured in the strain data sheets. Therefore, we cannot guarantee a strain's phenotype will meet all expectations. To ensure that JAX® Mice will meet the needs of individual research projects or when requesting a strain that is new to your research, we suggest ordering and performing tests on a small number of mice to determine suitability for your particular project. We do not guarantee breeding performance and therefore suggest that investigators order more than one breeding pair to avoid delays in their research.
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