This inbred mutant strain carries the the extreme nonagouti (ae) and white bellied agouti Jackson (Aw-J) coat color mutations along with the bradypneic (bd) spontaneous mutation.Read More +
This strain is segregating for recessive ae and dominant Aw-J.
Homozygous bd/bd mice show variable weight retardation beginning at 3 to 5 days. Severely affected mice die within the first two weeks; less severely affected mice may survive to weaning or to adulthood and may be fertile. Homozygotes tested at 3 weeks or older breathe at half the normal rate, but breathing is deeper and 02 consumption per unit of body surface is normal. Blood pH and blood C02 capacity are normal, and no obstruction has been found in the nasal passages, larynx, trachea, or bronchi. The lungs are somewhat emphysematous and the right atrium is enlarged. There is dilation of some of the distal tubules of the kidney, and large amounts of gas in the stomach and intestines. The cause of the breathing defect is not known, but the breathing defect may be responsible for the emphysema, intestinal gas, small size, and early death. (J:65322 Green MC, et al., bd - bradypneic. Mouse News Lett. 1977;56:40)
Bradypneic (bd) was found in December 1969 in the 21st generation of inbreeding of a strain segregating for Aw-J and ae/ae. Embryos produced by mating either Aw-J/ae bd/bd or ae/ae bd/bd males to AEJ/GnLeJ (Stock No. 000199) females were cryopreserved in 1983.
|Allele Name||extreme nonagouti|
|Allele Type||Radiation induced|
|Gene Symbol and Name||a, nonagouti|
|Strain of Origin||(P x S)F1|
|General Note||The ae mutation was found among descendants of an irradiated mouse. ae is recessive to all other alleles except al.|