Homozygous bd/bd mice show variable weight retardation beginning at 3 to 5 days. Severely affected mice die within the first two weeks; less severely affected mice may survive to weaning or to adulthood and may be fertile. Homozygotes tested at 3 weeks or older breathe at half the normal rate, but breathing is deeper and 02 consumption per unit of body surface is normal. Blood pH and blood C02 capacity are normal, and no obstruction has been found in the nasal passages, larynx, trachea, or bronchi. The lungs are somewhat emphysematous and the right atrium is enlarged. There is dilation of some of the distal tubules of the kidney, and large amounts of gas in the stomach and intestines. The cause of the breathing defect is not known, but the breathing defect may be responsible for the emphysema, intestinal gas, small size, and early death. (J:65322 Green MC, et al., bd - bradypneic. Mouse News Lett. 1977;56:40)

This inbred mutant strain carries the the extreme nonagouti (ae) and white bellied agouti Jackson (Aw-J) coat color mutations along with the bradypneic (bd) spontaneous mutation.

Typically mice are recovered in 12-16 weeks. Contact Customer Service to place an order or for more information.

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