This B6/By congenic strain, originally developed on the basis of a histoincompatibility with the BALB/cBy strain, initially named H-28c, and currently named Ifi44lc. The strain carries the If1h allele of C57BL/6By. See also Stock No. 000142, Stock No. 000146, and Stock No. 000384. These independently derived congenic strains all carry a BALB/cBy Chromosome 3 segment containing Ifi44lc.
Genetic Background | Generation |
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000663 C57BL/6By |
|
Allele Type | Gene Symbol | Gene Name |
---|---|---|
Spontaneous (Not Applicable) | Ifi44l | interferon-induced protein 44 like |
Marker Symbol | Marker Name | |
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If1 | NDV-induced circulating interferon |
This B6/By congenic strain, originally developed on the basis of a histoincompatibility with the BALB/cBy strain, initially named H-28c, and currently named Ifi44lc. The strain carries the If1h allele of C57BL/6By. See also Stock No. 000142, Stock No. 000146, and Stock No. 000384. These independently derived congenic strains all carry a BALB/cBy Chromosome 3 segment containing Ifi44lc.
Dr. Donald Bailey, then at University of California Medical Center in San Francisco, began to generate a panel of congenic lines with differential loci that determine histocompatibility by crossing BALB/cBy females with C57BL/6By males, and then backcrossing at each generation to a C57BL/6J male. At backcross generation 5 orthotopic tailskin graft tests were done to identify lines bearing BALB/cBy-derived congenic intervals with histocompatibility loci. This backcrossing, with testing, was continued until siblings at backcross generation 11 or more were intercrossed to breed the congenic interval to homozygosity and each strain was maintained by sibling inbreeding (Bailey 1975 Immunogenetics 2:249-56). Dr. Bailey transferred the mice to The Jackson Laboratory when he joined the staff in 1967. The strain was cryopreserved in 1980 at generation N15F41.
Allele Name | histocompatibility 28, c variant |
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Allele Type | Spontaneous (Not Applicable) |
Allele Synonym(s) | H28c |
Gene Symbol and Name | Ifi44l, interferon-induced protein 44 like |
Gene Synonym(s) | |
Strain of Origin | BALB/cBy |
Chromosome | 3 |
Molecular Note | This minor histocompatibility antigen, formerly designated H28, was traced to the ILENFPRL peptide from this gene in the BALB/cBy genome, distinct from the sequence in the C57BL/6J genome. This peptide is presented in Kb and stimulates C57BL/6By hosts to reject BALB.B grafts. |
Marker Synonym(s) | |
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Chromosome(s) | 3 |
When using the HW110 mouse strain in a publication, please cite the originating article(s) and include JAX stock #000116 in your Materials and Methods section.
Facility Barrier Level Descriptions
Service/Product | Description | Price |
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Inbred, 1 pair minimum will be supplied |
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The Jackson Laboratory has rigorous genetic quality control and mutant gene genotyping programs to ensure the genetic background of JAX® Mice strains as well as the genotypes of strains with identified molecular mutations. JAX® Mice strains are only made available to researchers after meeting our standards. However, the phenotype of each strain may not be fully characterized and/or captured in the strain data sheets. Therefore, we cannot guarantee a strain's phenotype will meet all expectations. To ensure that JAX® Mice will meet the needs of individual research projects or when requesting a strain that is new to your research, we suggest ordering and performing tests on a small number of mice to determine suitability for your particular project. We do not guarantee breeding performance and therefore suggest that investigators order more than one breeding pair to avoid delays in their research.
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