Overview

Due to poor production, this strain is currently not available to order. If you register interest you will be notified when orders can again be taken.

The BXH set of RI strains is used in the genetic analysis of numerous complex or potentially complex physiologic phenotypes including differences in thyroid function (Graves' disease), bone mineral density, atherosclerosis and leukemia. The BXH set is derived from the C57BL/6J (Stock No. 000664) and C3H/HeJ (Stock No. 000659) progenitor strains.

Genetic overview

Genetic Background	Generation
	F147+46 (2020-12-03 00:00:00)

Micrl^R

Allele Type	Gene Symbol	Gene Name
QTL	Micrl	microwave induced increase in complement receptor B cells

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Research Applications

Research Tools

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Details

Detailed Description

The BXH set of RI strains is used in the genetic analysis of numerous complex or potentially complex physiologic phenotypes including differences in thyroid function (Graves' disease), bone mineral density, atherosclerosis and leukemia.
A SNP data set is available through the Mouse Phenome Database for the BXH strains.
Another BXH genotype data set consists of 472 MIT CA-repeat dinucleotide microsatellite markers that were typed at UTHSC from 1998 through 2000. The file is taken directly from Williams and colleagues (2001) without any significant modification in genotypes. This order of markers has been updated to conform to the March 2005 assembly of the mouse genome (Build 34 or UCSC mm6). The data set may be downloaded from the University of Tennessee Gene Network site . A data set from Mouse Genome Informatics
Contributed Data Sets is also available.

Tools for using the RI set are presented through the Mouse Phenome Database

Specialized Strain Panel Query Form, and

Gene Network.

Development

The first 12 BXH recombinant inbred (RI) lines were generated and maintained at The Jackson Laboratory by Dr. Benjamin Taylor (labcode Ty) in 1969. Dr. Linda Siracusa at the Kimmell Cancer Center (labcode Kcc) generated a second set of 8 strains in 1995 by selecting for tyrosinase-negative albinos; a gene on the central part of chromosome (Chr) 7. BXH strains are derived from the C57BL/6J (Stock No. 000664) and C3H/HeJ (Stock No. 000659) progenitor strains. Several of the original strains are extinct. The Jackson Laboratory currently distributes 10 of the original Ty strains and 2 of the Kcc strains.

Selected References

Williams RW; Gu J; Qi S; Lu L. 2001. The genetic structure of recombinant inbred mice: high-resolution consensus maps for complex trait analysis. Genome Biol 2(11):1-18PubMed: 11737945 MGI: J:73062

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Genetics

Micrl^R

Allele Symbol: Micrl^R

Allele Name	responder
Allele Type	QTL
Allele Synonym(s)
Gene Symbol and Name	Micrl, microwave induced increase in complement receptor B cells
Gene Synonym(s)
Strain of Origin	multiple strains
Chromosome	5
General Note	Carriers of this dominant QTL respond to microwave exposure with an increase in splenic C3 receptor-bearing B cells. The following inbred strains are homozygous for Micrl: AKR/J, C3H/HeJ, C3H/HeN, CBA/J, CBA/N, DBA/2J, and JGBF/LeTy. These recombinant inbred strains are also responders: BXH3/Ty, BXH4/Ty, BXH8/Ty, BXH9/Ty, BXH10/Ty, and BXH19/Ty.

Disease/Phenotype

Disease Terms

Research Areas By Phenotype

This mouse can be used to support research in many areas including:

Research Tools
- Genetics Research
  - Gene Mapping: Tools for QTL Mapping, Segregation and Linkage Analysis
  - Gene Mapping

Mammalian Phenotype Terms by Genotype

Phenotype Information

Wellcome Trust Centre for Human Genetics: Mouse Recombinant Inbred Line (RIL) Genotype Data for BXH RI Line

References

Williams RW; Gu J; Qi S; Lu L. 2001. The genetic structure of recombinant inbred mice: high-resolution consensus maps for complex trait analysis. Genome Biol 2(11):1-18PubMed: 11737945 MGI: J:73062

Additional References

Hamidi S; Aliesky HA; Williams RW; Rapoport B; McLachlan SM. 2013. Genetic linkages for thyroxine released in response to thyrotropin stimulation in three sets of recombinant inbred mice provide evidence for shared and novel genes controlling thyroid function. Thyroid 23(3):360-70PubMed: 22988948 MGI: J:204730
McLachlan SM; Aliesky HA; Pichurin PN; Chen CR; Williams RW; Rapoport B. 2008. Shared and unique susceptibility genes in a mouse model of Graves' disease determined in BXH and CXB recombinant inbred mice. Endocrinology 149(4):2001-9PubMed: 18162518 MGI: J:136028
McLachlan SM; Lu L; Aliesky HA; Williams RW; Rapoport B. 2011. Distinct genetic signatures for variability in total and free serum thyroxine levels in four sets of recombinant inbred mice. Endocrinology 152(3):1172-9PubMed: 21209025 MGI: J:173883
Siracusa LD; Buchberg AM; Copeland NG; Jenkins NA. 1989. Recombinant inbred strain and interspecific backcross analysis of molecular markers flanking the murine agouti coat color locus. Genetics 122(3):669-79PubMed: 2759422 MGI: J:9913

Additional - Micrl^R related

Technical Support

CONTACT TECHNICAL SUPPORT

Genotyping Protocols
- Genotyping resources and troubleshooting
Dietary Information
- LabDiet® 5K52 formulation (6% fat)
Mating System
- Sibling x Sibling
Appearance
- agouti
  Related Genotype: A/A
Citation
When using the BXH9/TyJ mouse strain in a publication, please cite the originating article(s) and include JAX stock #000008 in your Materials and Methods section.

Animal Health Reports

Facility Barrier Level Descriptions

FGB29 (Standard)

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Genetic overview

Research Applications

Detailed Description

Development

Selected References

MicrlR

Allele Symbol: MicrlR

Disease Terms

Research Areas By Phenotype

This mouse can be used to support research in many areas including:

Mammalian Phenotype Terms by Genotype

Phenotype Information

References

Additional References

Additional - MicrlR related

Genotyping Protocols

Dietary Information

Mating System

Appearance

Citation

Animal Health Reports

Strain Interest Registration

Contact Information

Interest

Terms Of Use

Licensing Information

Micrl^R

Allele Symbol: Micrl^R

Additional - Micrl^R related