Gametocyte specific factor 1 (GTSF1) is a conserved, 19,083 Da, tandem CHHC-type zinc-finger protein essential for piRNA function and fertility in flies, silk moths, worms, and mice. The mRNA abundance of Gtsf1 rises sharply as male germ cells enter meiosis I, peaks in secondary spermatocytes, and then declines in round spermatids. Gtsf1Flag knock-in mice express Flag- and hemagglutinin (HA)-tagged GTSF1 protein from the endogenous Gtsf1 mouse promoter. Homozygotes show no overt phenotype. Endogenous expression of the targeted gene is retained. This strain has been used to purify and estimate the expression levels of GTSF1 protein.

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Gtsf1Flag knock-in mice express Flag- and hemagglutinin (HA)-tagged gametocyte specific factor 1 (GTSF1) protein from the endogenous Gtsf1 mouse promoter. This strain has been used to purify and estimate the expression levels of GTSF1 protein.

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