Slco1c1-CreERT2 mice express a tamoxifen-inducible codon-improved icre/ERT2 fusion gene under the control of the mouse solute carrier organic anion transporter family, member 1c1 (Slco1c1) locus (derived from a BAC). Slco1c1 encodes a transmembrane protein that mediates the sodium-independent uptake of thyroid hormones in brain tissues and facilitates their transport across the blood-brain barrier and into glia in the brain. In this strain, SLCO1C1 directs expression of the tamoxifen-inducible iCre recombinase specifically to endothelial cells in the brain and epithelial cells of the choroid plexus. When transgenic mice are bred with mice containing loxP-flanked sequences, tamoxifen-inducible iCre-mediated recombination will result in deletion of floxed sequences in endothelial cells in the brain and choroid plexus epithelial cells of the offspring. Hemizygous mice are viable and fertile with no reported phenotype abnormalities. The donating investigator did not attempt to make a homozygous colony, it is unknown if homozygotes are viable and fertile. Some iCre activity is evident in the target cells prior to tamoxifen administration
 Of note, Slco1c1-Cre (Stock No. <a href="https://www.jax.org/strain/040079">040079</a>) are a similar transgenic line that expresses constitutively active Cre recombinase in endothelial cells in the brain.

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Slco1c1-CreERT2 mice express a tamoxifen-inducible codon-improved icre/ERT2 fusion gene under the control of the mouse Slco1c1 locus. This strain allows temporally controlled deletion of floxed genes in endothelial cells in the brain and epithelial cells of the choroid plexus.

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