GlyT2::Dre transgenic mice express Dre recombinase under the control of the murine solute carrier family 6 (neurotransmitter transporter, glycine), member 5 (Slc6a5) promoter. GlyT2 encodes a membrane glycoprotein that is an established marker of glycinergic neurons. GlyT2 is expressed in the central nervous system (CNS) in two splice variants (GlyT2a and GlyT2b), which differ in their N-termini as a result of the use of alternative first exons (exon 1a and exon 1b). In this strain, dre cDNA was inserted in frame into the beginning of exon 2 and exon 2 was subsequently removed. When crossed with a strain containing a roxP site-flanked sequences, Dre-mediated recombination will result in deletion of the roxed sequences in the dre-expressing cells of the offspring. These GlyT2::Dre transgenic mice allow recombination of rox sites not only in glycinergic inhibitory neurons but also in inhibitory neurons that become purely GABAergic in adulthood. Of note, GlyT2::Dre recombination spares the forebrain where GlyT2 is never expressed. Homozygous mice are viable and fertile.

Use of MICE only available to non-profit entities.

GlyT2::Dre transgenic mice express Dre recombinase under the control of the murine Slc6a5 promoter. They may be useful for site-specific recombination in glycinergic neurons.

Typically mice are recovered in 12-16 weeks. Contact Customer Service to place an order or for more information.

<a target="_blank" href="https://www.jax.org/jax-mice-and-services/customer-support" rel="noreferrer">Contact Customer Service</a> for more information.