Appbp2 (amyloid beta precursor protein (cytoplasmic tail) binding protein 2) is expressed in most tissues. Exon 2 of the mouse Appbp2 gene is flanked by loxP sites in these Appb2 flox mice. Cre recombinase-mediated excision of the floxed region is creates a frameshift resulting in a knock-out allele, as confirmed by qPCR and western blot. The mice have been useful for studying the role of the gene in the regulation of thermogenesis, obesity, and diabetes.

Appbp2 flox mice, in which exon 2 of the mouse Appbp2 (amyloid beta precursor protein (cytoplasmic tail) binding protein 2) gene is flanked by loxP sites, may be useful for studying the role of the gene in the regulation of thermogenesis, obesity, and diabetes. Cre recombinase-mediated excision of the floxed region results in a knock-out allele.