Atf3 (activating transcription factor 3), rapidly induced after axonal injury, is implicated in cellular reprogramming and is necessary for axotomy-induced transcriptional reprogramming, axonal regeneration, and sensory recovery after injury. Atf3 is expressed at low levels in many tissues including neurons, hepatocytes, adipocytes, and immune cells. These Atf3-CreERT2 mice express tamoxifen-inducible Cre recombinase from the mouse Atf3 promoter. Endogenous expression of the mouse Atf3 gene is preserved. Atf3-CreERT2 mice crossed with Gcamp6f f animals (see Stock No. <a href="https://www.jax.org/strain/024105">024105</a>) have been useful in studies of neuronal injury and regeneration. This reporter system efficiently marks injured Atf3+ dorsal root ganglion (DRG) neurons one week after crush injury (Renthal, 2020; PMID: <a href="https://pubmed.ncbi.nlm.nih.gov/32810432/">32810432</a>).

The use of this mouse model is subject to the terms and conditions of the Limited Use Label License from Caribou Biosciences, Inc.

The use of this mouse strain or other product (the "Licensed Product") is subject to the terms and conditions of the Limited License from The Broad Institute.

Use of MICE by companies or for-profit entities requires a license prior to shipping.

Atf3-CreERT2 mice express tamoxifen-inducible Cre recombinase from the mouse Atf3 (activating transcription factor 3) promoter and have been useful in studies of neuronal injury and regeneration.

Typically mice are recovered in 12-16 weeks. Contact Customer Service to place an order or for more information.

<a target="_blank" href="https://www.jax.org/jax-mice-and-services/customer-support" rel="noreferrer">Contact Customer Service</a> for more information.