Atl1WT knock-in (KI) mice harbor a humanized WT exon 12 replacing equivalent mouse exon 13 in the atlastin GTPase 1 (Atl1) gene. 
 ATL1 is a GTPase and Golgi body transmembrane protein which plays a role in formation of the tubular endoplasmic reticulum network and in axon elongation in neurons. Atl1 mutations are implicated in Hereditary spastic paraplegia (HSP) and Hereditary Sensory Neuropathy type 1D (HSN1D). Heterozygous and homozygous Atl1WT mice are viable and fertile with no overt phenotype. The donating laboratory indicates that homozygous mice are born in lower than expected Mendelian ratios from heterozygous intercrosses (~19.3%). If additional characterization of these mice is performed, we may modify the strain description accordingly.

The use of this mouse model is subject to the terms and conditions of the Limited Use Label License from Caribou Biosciences, Inc.

The use of this mouse strain or other product (the "Licensed Product") is subject to the terms and conditions of the Limited License from The Broad Institute.

At11WT knock-in mice carry a humanized wildtype exon 12 replacing equivalent mouse exon 13 in the atlastin GTPase 1 (Atl1) gene. This strain may be useful for studying the role of ATL1 in the formation of the tubular endoplasmic reticulum (ER) network and in axon elongation in neurons.

This strain is hosted by NIH's MMRRC, which partners with JAX for the distribution of this and other strains. For additional information and to purchase, please visit the MMRRC site.