Lrig1 (leucine-rich repeats and immunoglobulin-like domains 1) regulates stem cell quiescence. When used as a marker, it identifies stem cells in multiple organs of the mouse, including cultured Id1high neural stem cells obtained from the lateral walls lining the lateral ventricles of the adult mouse brain. Lrig1T2A-tdTomato knock-in mice express tdTomato fluorescent protein from an undisrupted mouse Lrig1 (leucine-rich repeats and immunoglobulin-like domains 1) gene. The donating laboratory states the reporter protein is "very sensitive" and extremely bright, highlighting several discrete cell populations including ventricular-subventricular zone (V-SVZ) cells. This line would be useful for investigation of quiescent, non-proliferative stem cell populations in the brain, intestine, and skin, as well as other organs.

Lrig1T2A-tdTomato knock-in mice express tdTomato fluorescent protein from an undisrupted mouse Lrig1 (leucine-rich repeats and immunoglobulin-like domains 1) gene. This line would be useful for investigation of quiescent, non-proliferative stem cell populations in the brain, intestine, and skin, as well as other organs.

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