Kcnma1 (potassium large conductance calcium-activated channel, subfamily M, alpha member 1) encodes the pore-forming alpha subunit of the BK voltage and calcium-sensitive potassium channel (KCa1.1). BK channels regulate membrane potential and repolarization of action potentials and are widely expressed in neurons,smooth muscle, neuroendocrine, and non-excitable cells such as bone and kidney. Mutations in Kcnma1 are associated with paroxysmal non-kinesigenic dyskinesia (PKND3) and epileptic seizures, as well as neurodevelopmental disorder. 
 These conditional Kcnma1fl-tdTomato mice possess loxP sites flanking exon 2 and a 2A-tdTomato reporter in reverse orientation. Mice that are homozygous for this floxed allele are viable and fertile. When bred to mice that express tissue-specific Cre recombinase, resulting offspring will have exon 2 inverted and the 2A-tdTomato reporter brought in frame (and expressed) in cre-expressing tissues.
 For example, when bred to mice with Cre recombinase expression in neurons of the central and peripheral nervous systems (for example, <a href="https://www.jax.org/strain/003771">Tg(Nes-cre)1Kln</a> and SM222a-Cre), homozygous knockout offspring were verified to lack BK currents in neurons of the suprachiasmatic nucleus and mesenteric artery smooth muscle cells.

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Kcnma1fl-tdTomato conditional mutant mice possess loxP sites flanking exon 2 and a tdTomato reporter (that only expresses upon cre recombination) in the Kcnma1 (potassium large conductance calcium-activated channel, subfamily M, alpha member 1) gene and may be useful in generating conditional mutations to study the function of BK currents.

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