Mcub (mitochondrial calcium uniporter dominant negative beta subunit) is a protective cardiac-inducible gene that reduces mitochondrial Ca2+ influx and permeability transition pore opening after ischemic injury to reduce ongoing pathological remodeling. Mcub-loxP mice carry a knock-in allele of the mouse Mcub gene in which exon 2 is flanked by loxP sites. Floxed allele mice show normal MCUB expression. Cre recombinase-mediated excision of the floxed region results in a knock-out allele useful in studies of cardiac remodeling. Infection of immortalized Mcub-loxP embryonic fibroblasts with an adenovirus expressing cre recombinase (AdCre) results in a complete deletion and loss of MCUB protein.

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Mcub-loxP mice carry a knock-in allele of the mouse Mcub (mitochondrial calcium uniporter dominant negative beta subunit) gene in which exon 2 is flanked by loxP sites. Cre recombinase-mediated excision of the floxed region results in a knock-out allele useful in studies of cardiac remodeling.

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