Zfp106 (formerly H3a) and H3b are minor histocompatibility genes that comprise the H3 locus. R03 is minor histocompatibility congenic strain that carries the closely linked Zfp106H3a-b B2ma and H3bb alleles derived from the LP strain on a C57BL/10Sn background. The companion R19 strain (MMRRC <a href="https://www.jax.org/strain/033911"">50799</a>) carries the LP-derived Zfp106H3a-b B2ma alleles, but not the H3bb allele on a C57BL/10Sn background. Mice homozygous for the LP-derived alleles are viable and fertile. Corneal allografts are one of the most common and successful tissue transplants in part because the cornea and anterior segment of the eye are immune privileged sites and do not require major histocompatibility complex (MHC) matching. However, those grafts that are rejected express minor histocompatibility (H) alloantigens. Corneal and skin allografts between R03 and R19 result in rejection of R03 donor corneas (expressing the H3bb allele) by R19 recipients but not the reverse. R03 mice and R19 mice (MMRRC <a href="https://www.jax.org/strain/033911"">50799</a>) provide a tool to dissect the role of the minor H3 alloantigens in corneal and skin allografts.

R03 is minor histocompatibility congenic strain that carries the H3 locus derived from the LP strain on a C57BL/10Sn background. The strain may be useful for studying the role of minor histocompatibility genes in transplant rejection.

This strain is hosted by NIH's MMRRC, which partners with JAX for the distribution of this and other strains. For additional information and to purchase, please visit the MMRRC site.