The Adcy5 (adenylate cyclase 5) gene encodes a membrane-bound adenylyl cyclase involved in the conversion of ATP to cAMP. Mutations in this gene have been associated with type 2 diabetes and ADCY5-related dyskinesia, a disorder characterized by abnormal involuntary movements. To create the Adcy5del101allele, CRISPR/Cas9 endonuclease-mediated genome editing of Adyc5 created a 101 bp deletion beginning in exon 10 and terminating in intron 10. If additional characterization of Adcy5del101 mice is performed, we may modify the strain description accordingly. Homozygous mice are viable and fertile.

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Adcy5del101 is a CRISPR/Cas9 generated mutant of the adenylate cyclase 5 gene carrying 101 nt deletion beginning in exon 10 and terminating in intron 10. These mice may be useful in studying ADCY5-related dyskinesia.

This strain is hosted by NIH's MMRRC, which partners with JAX for the distribution of this and other strains. For additional information and to purchase, please visit the MMRRC site.