Cerebellins are secreted glycoproteins that belong to the C1q and tumor necrosis factor (TNF) superfamily.&nbsp; They function as trans-synaptic cell-adhesion molecules that critically contribute to the formation and/or function of synapses and are differentially expressed in selective subsets of neurons throughout the brain. These Cbln4flox mice carry a targeted conditional reporter of Cbln4 (cerebellin 4 precursor protein) activity. Any cell that expresses Cbln4 will also express IRES-mVenus.&nbsp; Following cre-mediated recombination, the IRES-mVenus is deleted and the cells will express IRES-tdTomato. Both mVenus an tdTomato can be visualized directly, but the tdTomato is significantly weaker than the mVenus, thus the use of antibody for detection is recommended. Cbln2 (see stock# <a href="https://www.jax.org/strain/032949" target="_blank">032949</a>) and Cbln4 are broadly expressed in largely non-overlapping subpopulations of excitatory cortical neurons, but only sparse expression was observed in excitatory hippocampal neurons of the CA1- or CA3-region. Similarly, Cbln2 and Cbln4 are selectively expressed, respectively, in inhibitory interneurons and excitatory mitral projection neurons of the main olfactory bulb; here, these two classes of neurons form dendrodendritic reciprocal synapses with each other.

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Cbln4flox mice carry a targeted conditional reporter of Cbln4 (cerebellin 4 precursor protein) activity. Any cell that expresses Cbln4 will also express IRES-mVenus.&nbsp; Following cre-mediated recombination, the IRES-mVenus is deleted and the cells will express IRES-tdTomato.

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