TS1 mice express rearranged V&#945 4, J&#945 2B4/V&#946 8.2, V&#946 2.1 T cell receptor chains specific for peptide 111-119 from influenza virus A/PR/8/34 hemagglutinin (PR8 HA). The Class II I-Ed restricted epitope found in PR8-HA is known as the S1 determinant, a T cell determinant recognized by BALB/c mice. Mice homozygous for the transgene are viable and fertile with no observable phenotype. When combined with Tg(H2-Ea-HA)HACIIAcja transgenic mice (MMRRC Stock No. <a href="https://www.jax.org/strain/031460"">043832</a>) expressing PR8 hemagglutinin (HA) neo-self antigen under the direction of the mouse MHC Class II Ea (H2-Ea) promoter, progeny develop spontaneous inflammatory arthritis with a female sex bias and a B cell requirement for disease development. Male mice exhibit decreased severity and a delay in disease onset as compared to female mice. 
When combined with Tg(SV40-HA*)HA28Ajca transgenic mice (MMRRC Stock No. <a href="https://www.jax.org/strain/031458"">043825</a>) expressing a truncated PR8 hemagglutinin (HA) neo-self antigen under the direction of the SV40 promoter, S1-specific T cells are not deleted, but undergo selection to become CD4+ Foxp3+ regulatory T cells. This mouse strain may be useful for studies of immune regulation, B and T cell tolerance, autoimmunity, and arthritis.

TS1 mice express rearranged T cell receptor &#945/&#946 chains specific for the MHC Class II I-Ed restricted S1 determinant site from influenza virus A/PR/8/34 hemagglutinin (PR8 HA). This mouse strain may be useful for studies of immune regulation, B and T cell tolerance, autoimmunity, and arthritis.

This strain is hosted by NIH's MMRRC, which partners with JAX for the distribution of this and other strains. For additional information and to purchase, please visit the MMRRC site.