C57BL/6J-Tg(Dcdc2a-cre)NIDA056Htz/Mmjax

Stock number: 031395
Product name: Dcd2a-Cre(NIDA056)
Research areas: Neurobiology Research, Research Tools

Description

These BAC transgenic mice express Cre recombinase from the mouse Dcdc2a gene (doublecortin domain containing 2a). Recombination has been observed in ependymal cells lining the ventricle of the brain, the choroid plexus, and tanycytes in the third ventricle.

Detailed description

These BAC transgenic mice express Cre recombinase from the mouse Dcdc2a gene (doublecortin domain containing 2a). Recombination has been observed in ependymal cells lining the ventricle of the brain, the choroid plexus, and tanycytes in the third ventricle.

Development

Mouse BAC RP23-123C5 was modified to incorporate Cre recombinase under the control of the Dcdc2a promoter. The modified BAC was microinjected into the pronucleus of an C57BL/6J zygote and randomly integrated into the mouse genome. The strain was maintained on C57BL/6J by the donating laboratory. This is founder line number NIDA056.

Allele

Symbol: Tg(Dcdc2a-cre)NIDA056Htz
Name: transgene insertion NIDA056, Nathaniel Heintz
MGI accession ID: MGI:5927708
Generation method: Transgenic
Attributes: Recombinase-expressing
Marker symbol: Tg(Dcdc2a-cre)NIDA056Htz
Marker name: transgene insertion NIDA056, Nathaniel Heintz
Chromosome: UN
Strain of origin: C57BL/6J
Expressed genes: cre,cre recombinase,bacteriophage P1
Site of expression: Recombination has been observed in ependymal cells lining the ventricle of the brain, the choroid plexus, and tanycytes in the third ventricle.
Molecular note: Mouse BAC RP23-123C5 was modified to incorporate Cre recombinase under the control of the Dcdc2a promoter.