The targeted S1pr1 gene encodes a receptor for sphingosine 1-phosphate that is highly expressed in endothelial cells, and is involved in regulation of cell adhesion, cell migration and angiogenesis. These S1p1f/stop/f mice carry a conditional S1pr1 expression cassette knocked into the mouse Gt(ROSA)26Sor locus (a loxP-flanked STOP cassette prevents transcription of S1pr1). Following Cre recombinase mediated excision of the floxed-STOP cassette, overexpression of S1pr1 from the Gt(ROSA)26Sortm1(CAG-S1pr1)Thla allele results. When bred to a strain with inducible widespread Cre recombinase expression, overexpression of S1pr1 results in decreased endothelial sprouting angiogenesis with reduced vascular network, vessel density, tip cells and branch points, as well as increased vessel dilation in the retina.


Mice that are homozygous for the mutant allele are viable and fertile.

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In these S1p1f/stop/f mice cre-mediated excision of a floxed STOP enables tissue-specific overexpression of S1pr1. This strain may be useful for generating conditional mutations in studies related to endothelial angiogenesis and vascular development.

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